Ornithine aspartate effervescent tablets and preparing process thereof
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A technology of ornithine aspartic acid and effervescent tablets, which is applied to medical preparations containing active ingredients, drug delivery, digestive system, etc., to achieve high bioavailability, rapid onset, and fast dissolution
Inactive Publication Date: 2014-06-18
PEKING UNIV FOUNDER GRP CO LTD +2
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Abstract
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Problems solved by technology
Therefore, adopting conventional method to prepare ornithine-aspartate effervescent tablet will not be able to avoid the degradation problem of ornithine-aspartate
Method used
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Embodiment 1
[0032] Embodiment 1 uses different organic acids to prepare ornithine-aspartic acid effervescent tablets
[0033] prescription
[0034] Citric acid (288 g), tartaric acid (338 g), fumaric acid (261 g), adipic acid (329 g) and malic acid (302 g) were used as acid agents, respectively. Other ingredients in the prescription are as follows:
[0035] Ornithine Aspartate
1000g
Povidone K30
45g
sodium bicarbonate
210g
stevia
0.75
orange flavor
0.75
[0036] polyethylene glycol 6000
150
production
1000 pieces
[0037] method
[0038] Using polyethylene glycol encapsulation-wet granulation process:
[0039] 1) Take polyethylene glycol 6000 and mix evenly with sodium bicarbonate, heat in a water bath at 70°C for 20 minutes to melt, then pulverize after cooling, and pass through an 80-mesh sieve.
[0040] 2) Take ornithine aspartate, add tartaric acid, mix evenly, use povidone K30 ethanol...
Embodiment 2-5
[0047] Embodiment 2-5: the screening of preparation process
Embodiment 2
[0048] Embodiment 2 dry granulation process
[0049] prescription
[0050] Ornithine Aspartate
1000g
Copovidone S630
45g
tartaric acid
338g
sodium bicarbonate
210g
stevia
0.75
orange flavor
0.75
polyethylene glycol 6000
30
production
1000 pieces
[0051] method
[0052] Using dry granulation process:
[0053] 1) Take ornithine aspartate, copovidone S630, tartaric acid, sodium bicarbonate, and mix well.
[0054] 2) Rolling into large pieces and crushing to obtain granules.
[0055] 3) Add stevioside, orange essence and polyethylene glycol 6000, mix well, and press into tablets.
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Abstract
The invention provides ornithine aspartate effervescent tablets and a preparing process thereof. The ornithine aspartate effervescent tablets comprise the components by mass percentage: 20%-65% of ornithine aspartate, 0%-5% of a binder, 15%-25% of a disintegrating acid agent, 10%-15% of a disintegrating alkali agent, and 0%-10% of a lubricant. The preparation process comprises a polyethylene glycol wrapping-wet granulation process comprising the steps of wrapping the disintegrating alkali agent with polyethylene glycol, then carrying out wet granulation of ornithine aspartate and the disintegrating acid agent, finally adding additional auxiliary materials, totally mixing, and tabletting. The prepared ornithine aspartate effervescent tablets have the following advantages that the disintegration speed is fast, the effervescent tablets can be disintegrated in 2-3 min, the dissolving speed is fast, the in-vivo absorption speed is fast, the acting is rapid, and the bioavailability is high.
Description
technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to an effervescent tablet of ornithine-aspartate and a preparation process thereof. Background technique [0002] In recent years, liver diseases such as viral hepatitis, fatty liver, alcoholic liver, and liver cancer have become one of the major diseases that endanger human health in today's society. In China, one out of every 12 people is suffering from liver disease. In addition to abnormal glucose metabolism, liver lesions can also cause elevated blood ammonia. The absorption of blood ammonia comes from intestinal ammonia production. When liver dysfunction occurs, on the one hand, it can reduce digestive function, Intestinal bacteria are active, and the amino acids produced in the intestines increase, resulting in elevated ammonia; The synthesis of urea from ammonia is reduced, and the removal of ammonia is insufficient, resulting in elevated blood ammonia....
Claims
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Application Information
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