Ornithine aspartate effervescent tablets and preparing process thereof

Abstract

The invention provides ornithine aspartate effervescent tablets and a preparing process thereof. The ornithine aspartate effervescent tablets comprise the components by mass percentage: 20%-65% of ornithine aspartate, 0%-5% of a binder, 15%-25% of a disintegrating acid agent, 10%-15% of a disintegrating alkali agent, and 0%-10% of a lubricant. The preparation process comprises a polyethylene glycol wrapping-wet granulation process comprising the steps of wrapping the disintegrating alkali agent with polyethylene glycol, then carrying out wet granulation of ornithine aspartate and the disintegrating acid agent, finally adding additional auxiliary materials, totally mixing, and tabletting. The prepared ornithine aspartate effervescent tablets have the following advantages that the disintegration speed is fast, the effervescent tablets can be disintegrated in 2-3 min, the dissolving speed is fast, the in-vivo absorption speed is fast, the acting is rapid, and the bioavailability is high.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to an effervescent tablet of ornithine-aspartate and a preparation process thereof. Background technique [0002] In recent years, liver diseases such as viral hepatitis, fatty liver, alcoholic liver, and liver cancer have become one of the major diseases that endanger human health in today's society. In China, one out of every 12 people is suffering from liver disease. In addition to abnormal glucose metabolism, liver lesions can also cause elevated blood ammonia. The absorption of blood ammonia comes from intestinal ammonia production. When liver dysfunction occurs, on the one hand, it can reduce digestive function, Intestinal bacteria are active, and the amino acids produced in the intestines increase, resulting in elevated ammonia; The synthesis of urea from ammonia is reduced, and the removal of ammonia is insufficient, resulting in elevated blood ammonia....

AI Technical Summary

Problems solved by technology

Therefore, adopting conventional method to prepare ornithine-aspartate effervescent tablet will not be able to avoid the degradation problem of ornithine-aspartate

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