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Clean and environment-friendly production method of N,N-dialkylglycine

A technology of dialkylglycine and barium dialkylglycine, which is applied in the field of preparation of N,N-dialkylglycine, can solve the problems of difficult biochemical treatment of wastewater, difficulty in separation and purification, and low product yield, and achieve purity And the effect of high yield, easy separation and purification, high yield and purity

Inactive Publication Date: 2014-06-25
CHONGQING UNISPLENDOUR INT CHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the patents US4968839 and EP1435351A1 use hydroxyacetonitrile and dimethylamine as raw materials to produce N,N-dialkylglycine, the process still has the following disadvantages: 1) Like the chloroacetic acid method, a large amount of inorganic acid salt is produced as a by-product; 2) It is difficult to separate and purify N,N-dialkylglycine and inorganic acid salts. The product contains a certain amount of inorganic acid salts, and the obtained product needs to be purified several times; 3) A large amount of salt and N,N-dialkyl Glycine wastewater makes the biochemical treatment of wastewater difficult; 4) The production cost is high and the yield of the product is low

Method used

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  • Clean and environment-friendly production method of N,N-dialkylglycine
  • Clean and environment-friendly production method of N,N-dialkylglycine
  • Clean and environment-friendly production method of N,N-dialkylglycine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] At room temperature, mix 1000g of 40% hydroxyacetonitrile aqueous solution with 1435g of 33% dimethylamine aqueous solution, then immediately use the feed pump to pump the resulting mixture into the tubular reactor, then raise the temperature to 80°C, and the gauge pressure is 1.0MPa , the residence time of the reaction material in the tubular reactor is 15 minutes, and the liquid flowing out from the outlet of the tubular reactor is directly added to a four-necked round bottom flask with 1106g60% barium hydroxide 3000ml, and the hydrolysis reaction temperature The temperature is 85°C, and the reaction time is 3 hours. After the hydrolysis reaction is completed, the hydrolyzed liquid is transferred to the gas stripping equipment for gas-liquid separation, and the dimethylamine is recovered. The liquid after the gas stripping is transferred to the high-pressure reactor and heated to 80 ℃, then carbon dioxide is introduced, the pressure of carbon dioxide is 0.2MPa, and the...

Embodiment 2

[0065] At room temperature, mix 1000g of 40% hydroxyacetonitrile aqueous solution with 1435g of 33% dimethylamine aqueous solution, then immediately use the feed pump to pump the resulting mixture into the tubular reactor, then raise the temperature to 80°C, and the gauge pressure is 1.0MPa , the residence time of the reaction material in the tubular reactor was 15 minutes, and the liquid flowing out from the discharge port of the tubular reactor was directly added to the solution containing 1106g60% barium hydroxide (the barium hydroxide was reclaimed in Example 1 and obtained). In a 3000ml four-necked round bottom flask, the hydrolysis reaction temperature is 85°C, and the reaction time is 3 hours. After the hydrolysis reaction is completed, the hydrolyzate is transferred to an air stripping device for gas-liquid separation, and dimethylamine is recovered. , the liquid after air stripping is transferred to a high-pressure reactor, heated to 80°C, and then carbon dioxide is in...

Embodiment 3

[0069] At room temperature, mix 1000g of 40% hydroxyacetonitrile aqueous solution with 1435g of 33% dimethylamine aqueous solution, then immediately use the feed pump to pump the resulting mixture into the tubular reactor, then raise the temperature to 80°C, and the gauge pressure is 1.0MPa , the residence time of the reaction material in the tubular reactor was 15 minutes, and the liquid flowing out from the discharge port of the tubular reactor was directly added to the 1325.6g50% barium hydroxide (this barium hydroxide was reclaimed in Example 2) obtained barium hydroxide) in a 3000ml four-necked round-bottomed flask, the hydrolysis reaction temperature was 85°C, and the reaction time was 3 hours. After the hydrolysis reaction was completed, the hydrolyzed solution was transferred to an air stripping device for gas-liquid separation, and dimethylformazol was recovered. Amine, the liquid after air stripping is transferred to a high-pressure reactor, heated to 80°C, and then c...

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Abstract

The invention aims at the chemical engineering field and relates to a preparation method of N,N-dialkylglycine. The method comprises the following steps: mixing glycolonitrile with dialkyl amine, or mixing formaldehyde, hydrocyanic acid and the dialkyl amine, and carrying out ammonolysis reaction, so as to obtain an N,N-dialkylamino acetonitrile reaction liquid; mixing the N,N-dialkylamino acetonitrile reaction liquid with barium hydroxide, and carrying out hydrolysis reaction, so as to obtain an N,N-dialkyl glycine barium water liquid; carrying out neutral reaction on the N,N-dialkyl glycine barium by virtue of sulfuric acid or carbon dioxide to obtain the N,N-dialkylglycine, and simultaneously filtering a byproduct, namely a barium salt precipitate. The method has the beneficial effects that the N,N-dialkylglycine and the salt are easily separated and purified, the purity and yield of the N,N-dialkylglycine are high, the barium salt precipitate, namely barium carbonate can be re-prepared into barium hydroxide to be recycled, and the production process is environment-friendly and clean.

Description

technical field [0001] The invention aims at the field of chemical industry and relates to a preparation method of N,N-dialkylglycine. Background technique [0002] N,N-dialkylglycine, its chemical structure is shown in the following formula: [0003] [0004] Wherein, R is an alkyl group. [0005] N, N-Dimethyl glycine (Dimethyl glycine, N, N-dimethyl glycine, referred to as DMG, vitamin B16) is a specific form of N, N-dialkyl glycine when the R group is a methyl group. Appearance is white crystal, soluble in water and ethanol. As a drug, N,N-dimethylglycine can be used to treat middle-aged and elderly depression, stimulate the human immune response, reduce the damage of pollution pollutants to the body, reduce the cholesterol content in the body, etc.; in addition, it can be used as an antioxidant in the food industry , can be used as a pharmaceutical intermediate in the pharmaceutical industry to synthesize a variety of biochemical drugs. Taking N,N-dimethylglycine...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C229/12C07C227/18
Inventor 吴传隆秦岭杨帆朱晓莉丁永良朱丽利王用贵李欧
Owner CHONGQING UNISPLENDOUR INT CHEM
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