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A kind of penicillin V potassium microcapsule and preparation method thereof

A technology of penicillin V and its preparation, which is applied in the field of penicillin V potassium microcapsules and its preparation, which can solve the problems of no antibacterial effect and achieve the effects of environmental protection, elimination of bad smell, and easy operation and implementation

Inactive Publication Date: 2016-06-08
北京中科锐进科技有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

No antibacterial effect on penicillinase-producing strains

Method used

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  • A kind of penicillin V potassium microcapsule and preparation method thereof
  • A kind of penicillin V potassium microcapsule and preparation method thereof
  • A kind of penicillin V potassium microcapsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Crush ethyl cellulose to 80 mesh, pulverize penicillin V potassium to 80 mesh, accurately weigh 1 g of penicillin V potassium and 1 g of ethyl cellulose, add ethyl cellulose to 80 mL of dichloromethane under stirring until completely dissolved , To obtain solution a; add penicillin V potassium to solution a stirred at a rotation speed of 400 rpm to obtain solution b, and the solution b is stirred at a rotation speed of 400 rpm for 20 min. Put 800mL of water in the water bath in the beaker, control the temperature of the water bath at 35℃, add 1g of the surfactant sodium lauryl sulfate while stirring, to obtain solution c, add solution b to solution c, and stir at 400rpm to 2 The methyl chloride was completely volatilized, the solid product was filtered under reduced pressure, the microcapsules were washed 3 times with distilled water, and dried to obtain 1.76 g of dry solid powder. The particle size ranges from 50 to 700μm, the average particle size is 131.9μm, and the p...

Embodiment 2

[0037] Crush ethyl cellulose to 80 mesh, pulverize penicillin V potassium to 80 mesh, accurately weigh 2 g of penicillin V potassium and 1 g of ethyl cellulose, add ethyl cellulose to 80 mL of dichloromethane under stirring until completely dissolved , To obtain solution a; add penicillin V potassium to solution a stirred at a rotation speed of 400 rpm to obtain solution b, and the solution b is stirred at a rotation speed of 400 rpm for 20 min. Put 500mL of water in the water bath in the beaker, control the temperature of the water bath at 35℃, add 1g of the surfactant sodium lauryl sulfate while stirring, to obtain solution c, add solution b to solution c, and stir at 400rpm to 2 The methyl chloride was completely volatilized, the solid product was filtered under reduced pressure, the microcapsules were washed 3 times with distilled water, and dried to obtain 1.82 g of dry solid powder.

Embodiment 3

[0039] Ethyl cellulose was pulverized to 80 mesh, penicillin V potassium was pulverized to 80 mesh, 2g penicillin V potassium and 2g ethyl cellulose were accurately weighed, and ethyl cellulose was added to 150 mL of dichloromethane under stirring until it was completely dissolved. Obtain solution a; add penicillin V potassium to solution a stirred at 400 rpm to dissolve to obtain solution b, and solution b is stirred at 400 rpm for 20 min. Put 800mL of water in the water bath in the beaker, control the temperature of the water bath at 35℃, add 1g of the surfactant sodium lauryl sulfate while stirring, to obtain solution c, add solution b to solution c, and stir at 400rpm to 2 The methyl chloride was completely volatilized, the solid product was filtered under reduced pressure, the microcapsules were washed 3 times with distilled water, and dried to obtain 1.6 g of dry solid powder.

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Abstract

The invention discloses a penicillin V potassium micro-capsule and a preparation method thereof. The penicillin V potassium micro-capsule consists of a core material penicillin V potassium and a capsule wall material ethyecellulose. The preparation method comprises the following steps: 1) smashing and dissolving ethyecellulose in dichloromethane to obtain a solution a; 2) dissolving the smashed penicillin V potassium under stirring at a rotating speed of 100-500rpm in the solution a to obtain a solution b, and continuously stirring for 20-30 minutes; 3) controlling temperature of water and dispersing a surfactant in water to obtain a solution c; and 4) under the condition of stirring at a speed of 100-500rpm, adding the solution b into the solution c to form the penicillin V potassium micro-capsule, continuously stirring till dichloromethane is fully volatilized, filtering under reduced pressure, and washing the micro-capsule three times by using distilled water, and drying to obtain the penicillin V potassium micro-capsule. According to the invention, the micro-capsule is prepared by a drying-in-liquid method to eliminate harmful smell of penicillin V potassium so as to improve the compliance of the patient. The preparation process of the micro-capsule uses easily available and low-price raw materials, is low in production cost, simple in process operation, easy to operate and implement and high in yield.

Description

Technical field [0001] The invention relates to a penicillin V potassium microcapsule and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations. Background technique [0002] Penicillin V potassium belongs to β-lactam antibiotics, suitable for mild to moderate infections caused by penicillin-sensitive strains, including tonsillitis, pharyngitis, scarlet fever, erysipelas caused by streptococcus; bronchitis caused by streptococcus pneumoniae , Otitis media, sinusitis; and skin and soft tissue infections caused by penicillin-sensitive Staphylococcus. Penicillin V potassium can also be used as a preventive drug for rheumatic fever recurrence and infective endocarditis, and it can also be used for spirochetal infection. It has antibacterial activity against most gram-positive bacteria, gram-negative cocci, individual gram-negative bacilli (such as Haemophilus), spirochetes and actinomycetes, but most staphylococcal strains (> 90%) includi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/50A61K31/43A61K47/38
Inventor 霍清杨晓方
Owner 北京中科锐进科技有限责任公司
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