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Fat-coated ZnO nanoparticles

A nano-zinc oxide and encapsulation technology, which is applied in liposome delivery, animal feed forming or processing, animal feed, etc., can solve the problems of low encapsulation efficiency, low zinc oxide content, and difficult release, and reduce spraying High, fine and uniform particles, cost-saving effect

Active Publication Date: 2015-08-19
河南启明饲料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the limitation of the currently used coating method, as the Chinese invention patent 201110296150.8 discloses a coating of submicron feed grade zinc oxide and its preparation method, it uses potato starch, ethyl cellulose, and magnesium stearate as materials and adopts three coatings. Coated zinc oxide is prepared by homogenizing, mixing, drying, and crushing methods, the coating procedure is complicated, and the manufacturing cost is high; Chinese invention patent 201010148547.8 discloses an enteric zinc oxide and its preparation method, using polypropylene Resin, talcum powder, diethyl phthalate, and ethanol are used as solvents, and the addition amount is about 1000mg / kg. Obviously, the release of the coated product is difficult, and more zinc oxide is excreted without being released. Diethyl diformate is not a good choice as a plasticizer
In practice, zinc oxide is mostly prepared by fat mechanical mixing or cold wind milling. The mechanical mixing method has a simple process, but the encapsulation rate is low and the mixing is not uniform. The spray milling method requires that the material is transported to the nozzle through a pipeline, and the material must be separated. Good fluidity, so the zinc oxide content of the coating is low. Generally, the effective substance content of the coating product is only about 30%, and there will be a burst release phenomenon in the intestinal tract of animals.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The coating material is prepared with 70% of hydrogenated vegetable oil, 20% of glyceryl adipate stearate, and 10% by weight of polyglycerol fatty acid ester.

[0024] Such as figure 1 As shown, add 350kg of the coating material prepared according to the above ratio into the jacketed dissolution kettle 1 (with agitator or ultrasonic generator, pressure P≥2MPa), seal it, and vacuum until the vacuum indication of the dissolution kettle is 0.09 MPa, open the hydrocarbon pump 3 to inject 2000L liquefied petroleum gas (or other solvents, compressed in advance, cooled to liquid and then stored in the storage tank 4), stirring, and hot water in the jacket to aid dissolution.

[0025] Put 150kg of nano-zinc oxide material in the encapsulation tank (using a rake dryer 2), and put the solution containing the coating material in the dissolution tank 1 through the hydrocarbon pump 5 into the rake dryer 2 and mix for 30 minutes. Open the gas valve 6 to decompress and remove the sol...

Embodiment 2

[0027] The coating material is prepared with 60% of palm stearin, 30% of glyceryl adipate stearate, and 10% by weight of polyglycerol fatty acid ester.

[0028] Such as figure 2 As shown, add 200kg of the coating material prepared according to the above ratio to the dissolution kettle 1 (with agitator or ultrasonic generator, pressure P≥2MPa), seal it, and vacuum until the vacuum indication of the dissolution kettle is 0.09MPa. Inject 1000L of butane (or other solvents) into pump 3, stir, pass hot water through the jacket to aid in dissolution, and stop the supply of hot water after the material liquid in dissolution kettle 1 becomes transparent.

[0029] Add 300kg nano-zinc oxide in the encapsulation kettle 2, vacuumize until the vacuum indication of the encapsulation kettle is 0.09MPa, open the hydrocarbon pump 5 and squeeze the feed liquid in the dissolving kettle 1 into the encapsulation kettle 2, stir and mix evenly (30 minutes); open the high-pressure pump 6 to introdu...

Embodiment 3

[0031] The coating material is prepared with 60% hydrogenated vegetable oil, 20% glyceryl adipate stearate, 10% glyceryl monostearate and 10% sucrose ester by weight.

[0032] Such as figure 2 As shown, add 100kg of the above-mentioned materials and the proportioned coating material to the dissolution kettle 1 (with agitator or ultrasonic generator, pressure P≥2MPa), seal it, and vacuum until the vacuum indication of the dissolution kettle is 0.09MPa. Turn on the hydrocarbon pump 3 to inject 1000L butane (or other solvents), stir, pass hot water through the jacket to aid dissolution, and stop the hot water supply after the feed liquid in the kettle becomes transparent.

[0033] Add 400kg of nano-zinc oxide in the encapsulation kettle 2, evacuate until the vacuum indication of the encapsulation kettle is 0.09MPa, open the hydrocarbon pump 5 to squeeze the feed liquid in the dissolving kettle 1 into the encapsulation kettle 2, stir Mix well (30 minutes). Turn on the high-pres...

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PUM

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Abstract

The invention discloses nano-zinc oxide coated with fat. The nano-zinc oxide coated with fat is prepared by the steps of compressing gaseous solvent liquefied petroleum gas and the like under normal pressure and at normal temperature to obtain liquid, and storing the liquid in a storage tank; putting a coating material in a dissolution kettle, vacuumizing, injecting the liquid solvent in the storage tank in the dissolution kettle, heating the liquid solvent to enable the liquid solvent to become a subcritical fluid, and mixing to enable the coating material to be dissolved; adding a certain quantity of nano-zinc oxide solid particles into an encapsulation kettle, sealing, vacuumizing, injecting a mixed solution in the dissolution kettle in the encapsulation kettle by opening a hydrocarbon pump, carrying out decompression to release the solvent, vacuumizing when the pressure in the encapsulation kettle reaches normal pressure, then emptying to enable the pressure in the encapsulation kettle to reach the normal pressure, and discharging to obtain the coated nano-zinc oxide finished product. The nano-zinc oxide has the advantages that the coating material is dissolved by the subcritical fluid and can uniformly permeates the surface of the nano-zinc oxide; as the coating material is diluted by the solvent, the ratio of the nano-zinc oxide to the coating material can be increased. With the adoption of a preparation method of the nano-zinc oxide, the coated nano-zinc oxide product with the nano-zinc oxide content is 50-80 percent.

Description

technical field [0001] The invention relates to a feed additive---zinc oxide, in particular to a nanometer zinc oxide coated with fat. Background technique [0002] Post-weaning piglets often suffer from symptoms such as anorexia or refusal to eat, diarrhea, edema, and growth retardation due to incomplete digestion, leading to increased morbidity and mortality of piglets, reducing the growth rate during the weaning period, and affecting the performance of the growth period. Therefore, the problem of diarrhea after weaning becomes one of the important problems to be solved urgently in the pig industry. Adding antibiotics and zinc oxide to the feed is currently the most commonly used method to solve this problem. As we all know, the extensive use of antibiotics can cause drug residues, which is the main hidden danger leading to food safety problems. If zinc oxide is used alone, the dose to prevent piglet diarrhea can be as high as 2500-3000mg / kg feed. This is because most of...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/127A23K1/175A23K20/158A23K20/20A23K40/30
Inventor 王宏雁曹胜炎
Owner 河南启明饲料有限公司