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Lycopene microcapsule prepared by adopting a double-coating method and preparation method thereof

A technology of lycopene and lycopene oil, which is applied in the field of preparation of lycopene microcapsules and lycopene extraction and preparation, can solve the problems of lycopene destruction, instability, oxidative decomposition, etc., to promote uniform concentration and improve dispersion Sexuality and solubility, and the effect of improving biological potency

Inactive Publication Date: 2014-07-30
XINJIANG UNIVERSITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] In view of the poor solubility of lycopene in water, which is not effectively overcome in the prior art, and is unstable to oxygen, heat and light, this makes them have great limitations in production, processing and application. The cis-isomer is easier to absorb than the trans-isomer. Heat treatment will change lycopene from trans to cis, but it will also undergo oxidation and decomposition. The VE, VE, and The real problem that phytosterols, etc. will also be destroyed

Method used

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  • Lycopene microcapsule prepared by adopting a double-coating method and preparation method thereof
  • Lycopene microcapsule prepared by adopting a double-coating method and preparation method thereof
  • Lycopene microcapsule prepared by adopting a double-coating method and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0054] Embodiment one: the preparation of lycopene microcapsules

[0055] Refer to attached figure 1 , adopt double-coating method to prepare the method for lycopene microcapsules, concrete steps are as follows:

[0056] (1) Preparation of tomato peels: Select non-mildew tomato peels, remove sundries, and wash the soil and sundries on the peels with clean water for later use.

[0057] (2) Preparation of lycopene oleoresin: the above prepared tomato pomace was treated with supercritical CO 2 Extraction, pressure 28MPa, extraction temperature 70-72.5°C, CO? flow rate 2500-2600kg / h, extraction time: 120min, under this process condition, lycopene with a purity of over 90% can be obtained; Medium supercritical CO 2 The extracted 6% lycopene oleoresin is used as a raw material, which ensures that the raw material does not contain any chemical components and solvent residues, and is safe and non-toxic.

[0058] (3) Lycopene purification process: Dissolve the lycopene oleoresin pr...

Embodiment 2

[0064] Example 2: Preparation of cis-lycopene by ultra-high pressure

[0065] The lycopene sample was dissolved in n-hexane with a concentration of 50 μg / mL, and packed into a polyethylene composite bag and vacuum-sealed. Ultrahigh pressure treatment was carried out under different pressure, time and temperature to investigate the degree of internal isomerization of lycopene and the content of lycopene.

[0066] Effect of different ultra-high pressure treatment conditions on lycopene isomerization: Through ultra-high pressure treatment under different pressure, time and temperature, the degree of internal isomerization of lycopene and the content of lycopene were investigated. The results are shown in Table 1.

[0067] Table 1: Effects of different treatment conditions on isomerization of lycopene

[0068] sample Proportion of cis-lycopene (%) Lycopene content (mg / g) untreated sample 13.25% 52.37mg / g 400Mpa, 10min, 50℃ 34.76% 87.94mg / g 5...

Embodiment 3

[0079] Embodiment three: Lycopene microcapsules one-time coating process test

[0080] The choice of primary coating lycopene wall material, wall material component ratio, core-wall ratio, emulsifier dosage and solid content were determined by single factor experiment, and the primary coated lycopene microcapsules were emulsified by ultrasonic assisted emulsification method The liquid is emulsified and dried by spray drying. Since ultrasonic-assisted emulsification and spray drying involve a variety of parameters, the uniform design experiment method was selected to screen and analyze the significance of each parameter, and finally the two most significant factors were determined to be positive together with the two most significant factors in the single factor. Submit experimental optimization to obtain the optimal process and formula.

[0081] Conclusion: The optimal process for the preparation of lycopene microcapsules by ultrasonic-assisted emulsification and spray dryi...

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Abstract

The invention discloses a lycopene microcapsule prepared by adopting a double-coating method and a preparation method thereof. An appropriate mixed wall material is adopted, an optimal emulsification condition and a drying technological parameter are researched, a supercritical fluid extraction technology and a superhigh-pressure isomerization treatment technology are combined, a double-coating method is adopted for preparing the lycopene microcapsule, a process for preparing the double-coated lycopene microcapsule adopts porous starch with the usage amount of 0.16% and beta-cyclodextrin with the usage amount of 0.16%, adsorption temperature is 50 DEG C, and adsorption time is 30 minutes; lycopene is closed in a capsule and isolated with the external environment, so that stability to light and oxygen is improved, serviceable range is expanded, the technical bottleneck existing in application of lycopene at present is effectively overcome, ratio of cis-isomer in the prepared lycopene microcapsule is 45-50%, and bioavailability is high; embedding rate can be 97.75%, lycopene carrying capacity is 40.70mg / g, and the lycopene microcapsule has strong practicability and high application value.

Description

[0001] technical field [0002] The invention relates to the technical field of extraction and preparation of lycopene. Specifically, the present invention relates to the technical field of preparing lycopene microcapsules by coating method. Background technique [0003] Lycopene, also known as lycopene, is one of the main pigments in ripe tomatoes and one of more than 600 carotenoids that have been found in nature. Studies in recent years have shown that lycopene can not only be used as a new type of functional natural pigment, but also has strong biological effects in preventing various diseases, preventing and fighting cancer, improving immune function, and preventing aging. function. Studies have shown that a daily intake of tomato products containing 40mg of lycopene is enough to significantly reduce the oxidation of low-density lipoprotein (LDL) and reduce the risk of certain diseases such as cancer and cardiovascular diseases. Therefore, lycopene has always been kn...

Claims

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Application Information

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IPC IPC(8): A61K9/50A61K31/01A61P35/00A61P37/04A61P39/06A61P9/00A23L1/30A23P1/04
Inventor 敬思群柴文杰时慧顾学健
Owner XINJIANG UNIVERSITY
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