Antibacterial chitosan gel and preparation method thereof

Abstract

The invention relates to antibacterial chitosan gel and a preparation method of the antibacterial chitosan gel. The preparation method includes the steps of preparing complex liquid containing chitosan, preparing a fibroin ethanol solution, preparing a carrageenan solution, preparing a quaternary phosphonium compound solution, preparing gel and other steps. According to the antibacterial chitosan gel, high-molecular-weight chitosan and low-molecular-weight chitosan compounds are used as main base materials in cooperation with antibiotic synergist, gelatinizing agents, histocyte repairing auxiliary materials and the like for being compounded, and use of other chemicals, biological drugs and other ingredients is avoided; as a result, the safety of the gel is improved, cost is reduced, irritation to patients is reduced, and health restoration of the patients is facilitated. The ability of the prepared antibacterial chitosan gel to resist bacteria such as staphylococcus aureus, coliform bacteria, streptococcus and pseudomonas aeruginosa reaches more than 99 percent, so the antibacterial chitosan gel shows good bacteriostatic ability.

Description

【Technical field】 [0001] The invention belongs to the technical field of medical drugs. More specifically, the present invention relates to an antibacterial chitosan gel, and also relates to a preparation method of the antibacterial chitosan gel. 【Background technique】 [0002] The superior properties of polymer hydrogel materials, such as swelling properties, viscoelastic behavior and appropriate mechanical strength, have attracted great interest and attention from many researchers, and the corresponding preparation and development research is changing with each passing day. , Its application has penetrated into various fields such as medical and health care, biomedicine, daily chemical industry, food, environmental protection, etc., and is still expanding to a wider application field. In particular, good biocompatibility makes it promising in biomedical applications, such as tissue fillers, drug sustained-release agents, enzyme embedding, protein electrophoresis, contact ...

AI Technical Summary

Problems solved by technology

[0004] There are following technical defects in these prior art: 1, though most gels take chitosan as the main matrix, they all load other medicines, including chemical medicines, biological medicines, Chinese herbal medicines or nano-silver etc., which are made of chitosan The purpose of the gel-forming dosage form is mainly to make the drug play a sustained release effect; 2. Generally, synthetic materials such as carbomer are used as the main material for forming the gel; 3. No other natural activities that can produce damaged tissue and cell repair are used. Biomass materials, product effectiveness and safety are limited