Method for functionally modifying surface of conductive substrate

Abstract

The invention discloses a method for functionally modifying a surface of a conductive substrate. The method comprises the following steps: (1) decorating a catecholamine polymer coating on the surface of the conductive substrate by using a three-electrode working system which takes a platinum electrode as a counter electrode, takes a saturated calomel electrode as a reference electrode, takes the conductive substrate as a working electrode, takes a phosphate buffer solution containing 10<-5>-1g/mL of catecholamine as electrolyte or takes a trihydroxy methyl-aminomethane hydrochloride buffer solution containing 10<-5>-1g/mL of catecholamine as electrolyte; and (2) putting the conductive substrate obtained in the step (1) and decorated by the catecholamine polymer coating in a functional molecule solution for reacting, and thus obtaining the conductive substrate with functionalized surface. The functional molecules are silver nitrate, polymer containing amino or sulfydryl, polypeptide or protein. The method disclosed by the invention is capable of regulating physical and chemical properties of the surface of the conductive substrate and has the advantages of being simple, convenient, efficient, environmentally-friendly and capable of easily achieving industrialized application.

Description

technical field [0001] The invention relates to the field of surface modification of solid materials, in particular to a method for functional modification of the surface of a conductive substrate. Background technique [0002] Because metal materials have good mechanical properties, fatigue resistance, excellent corrosion resistance, and are easy to process, they are widely used in medical devices such as artificial joints, artificial bones, and vascular stents. However, due to the lack of functional motifs recognized by human cells on the surface of biologically inert metal materials, the compatibility with human tissues is poor, which often leads to the occurrence of various clinical adverse events. [0003] The physical and chemical properties of the surface of metallic materials play a crucial role in their normal function. At present, the surface modification methods of metal materials mainly include plasma method, sol-gel method, layer-by-layer self-assembly, immobil...

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Problems solved by technology

[0005] However, this method also has many disadvantages that are difficult to overcome

Firstly, alkaline conditions make this method unsuitable for surface modification of materials prone to alkaline corrosion; secondly, the deposition rate of polydopamine on the substrate surface is slow; thirdly, the oxidative self-polymerization of dopamine under alkaline conditions will not only A polydopamine coating is formed on the surface of the substrate, and a large number of polydopamine particles are also formed in the solution

The formation of these polydopamine particles not only greatly reduces the effective utilization of dopamine molecules, but also leads to an increase in the surface roughness of the coating after being adsorbed on the surface of the polydopamine coating.

These shortcomings seriously hinder the application of polydopamine surface modification technology

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