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Method for functionally modifying surface of conductive substrate

A technology of surface functionalization and conductive substrate, applied in the direction of electrolytic organic material coating, etc., can solve problems such as hindering the application of polydopamine surface modification technology, reducing the effective utilization of dopamine molecules, increasing the surface roughness of the coating, etc., to achieve fast polymer Effect of coating formation rate, shortening polymerization time, avoiding the formation of polymer particles

Inactive Publication Date: 2014-09-24
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, this method also has many disadvantages that are difficult to overcome
Firstly, alkaline conditions make this method unsuitable for surface modification of materials prone to alkaline corrosion; secondly, the deposition rate of polydopamine on the substrate surface is slow; thirdly, the oxidative self-polymerization of dopamine under alkaline conditions will not only A polydopamine coating is formed on the surface of the substrate, and a large number of polydopamine particles are also formed in the solution
The formation of these polydopamine particles not only greatly reduces the effective utilization of dopamine molecules, but also leads to an increase in the surface roughness of the coating after being adsorbed on the surface of the polydopamine coating.
These shortcomings seriously hinder the application of polydopamine surface modification technology

Method used

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  • Method for functionally modifying surface of conductive substrate
  • Method for functionally modifying surface of conductive substrate
  • Method for functionally modifying surface of conductive substrate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] (1) Place the cleaned gold-plated silicon chip as a working electrode in tris hydrochloride buffer containing 1 mg / mL dopamine (containing 25 mM Tris, 140 mM NaCl and 3 mM KCl, pH=7.4).

[0044] The electrochemical polymerization reaction was carried out on a CHI660D electrochemical workstation, using a three-electrode system, in which the reference electrode was a 232-type saturated calomel electrode, and the counter electrode was a platinum sheet electrode. Electrochemical oxidative polymerization of dopamine was carried out by cyclic voltammetry under room temperature and nitrogen protection conditions. The selected potential scanning range was –0.5 to 0.5V, and the scanning speed was 20mV / s. After 3 hours of polymerization, the gold-plated silicon chip was taken out and deionized water was used. Rinse and dry with nitrogen gas for later use.

[0045] (2) Place polydopamine-modified gold-coated silicon wafers in 170 mg / mL silver nitrate solution and react at room tem...

Embodiment 2

[0049] (1) A 316L stainless steel cardiovascular stent was placed as a working electrode in tris hydrochloride buffer containing 1 mg / mL dopamine (containing 25 mM Tris, 140 mM NaCl and 3 mM KCl, pH=7.4).

[0050] The electrochemical polymerization was carried out on a CHI660D electrochemical workstation, using a three-electrode system, in which the reference electrode was a 232-type saturated calomel electrode, and the counter electrode was a platinum sheet electrode. Electrochemical oxidative polymerization of dopamine was carried out by cyclic voltammetry under room temperature and nitrogen protection conditions, the selected potential scanning range was –0.5 to 0.5V, and the scanning speed was 20mV / s. After 3 hours of polymerization, the cardiovascular stent was taken out with deionized water Rinse and dry with nitrogen gas for later use.

[0051] (2) Place polydopamine-modified cardiovascular stents in Tris hydrochloride buffer (10 mM, pH=8.5) containing 500 ng / mL of vasc...

Embodiment 3

[0055] (1) Place the ITO conductive glass as a working electrode in a phosphate buffer containing 2mg / mL norepinephrine (containing 137mM NaCl, 2.7mM KCl, 10mM NaCl, 2 HPO 4 and 2mMKH 2 PO 4 , pH=7.4).

[0056] The electrochemical polymerization was carried out on a CHI660D electrochemical workstation, using a three-electrode system, in which the reference electrode was a 232-type saturated calomel electrode, and the counter electrode was a platinum sheet electrode. The electrochemical oxidative polymerization of norepinephrine was carried out by cyclic voltammetry at room temperature and under the protection of nitrogen. The selected potential scanning range was –0.3~0.8V, and the scanning speed was 10mV / s. After 3 hours of polymerization, the ITO conductive glass was taken out, rinsed with deionized water, dried with nitrogen gas, and then used for later use.

[0057] (2) Place the polynorepinephrine-modified ITO conductive glass in tris hydrochloride buffer solution (10...

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Abstract

The invention discloses a method for functionally modifying a surface of a conductive substrate. The method comprises the following steps: (1) decorating a catecholamine polymer coating on the surface of the conductive substrate by using a three-electrode working system which takes a platinum electrode as a counter electrode, takes a saturated calomel electrode as a reference electrode, takes the conductive substrate as a working electrode, takes a phosphate buffer solution containing 10<-5>-1g / mL of catecholamine as electrolyte or takes a trihydroxy methyl-aminomethane hydrochloride buffer solution containing 10<-5>-1g / mL of catecholamine as electrolyte; and (2) putting the conductive substrate obtained in the step (1) and decorated by the catecholamine polymer coating in a functional molecule solution for reacting, and thus obtaining the conductive substrate with functionalized surface. The functional molecules are silver nitrate, polymer containing amino or sulfydryl, polypeptide or protein. The method disclosed by the invention is capable of regulating physical and chemical properties of the surface of the conductive substrate and has the advantages of being simple, convenient, efficient, environmentally-friendly and capable of easily achieving industrialized application.

Description

technical field [0001] The invention relates to the field of surface modification of solid materials, in particular to a method for functional modification of the surface of a conductive substrate. Background technique [0002] Because metal materials have good mechanical properties, fatigue resistance, excellent corrosion resistance, and are easy to process, they are widely used in medical devices such as artificial joints, artificial bones, and vascular stents. However, due to the lack of functional motifs recognized by human cells on the surface of biologically inert metal materials, the compatibility with human tissues is poor, which often leads to the occurrence of various clinical adverse events. [0003] The physical and chemical properties of the surface of metallic materials play a crucial role in their normal function. At present, the surface modification methods of metal materials mainly include plasma method, sol-gel method, layer-by-layer self-assembly, immobil...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C25D9/02
Inventor 计剑任科峰王金磊李伯超
Owner ZHEJIANG UNIV
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