A pharmaceutical composition for treating gallbladder-related diseases, preparation method and application thereof

A technology of composition and medicine, which is applied in the field of pharmaceutical composition for treating gallbladder-related diseases, preparation, and herbal medicine composition for treating digestive system diseases. It can solve the problems of patient death, relieve pain, inhibit normal bile secretion, The effect of suppressing excessive secretion of abnormal bile

Active Publication Date: 2018-03-02
SICHUAN RES INST OF NATURE DRUGS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Improper handling can cause death of the patient (Qin Changchun, Wu Xinmin, Report of Six Cases of Hypersecretion of Bile, Journal of Clinical Surgery, September 2001, Volume 9, No. 5, Pages 338-339). Hypersecretion of bile generally has no clinical symptoms. But it can cause serious consequences when doing external drainage of bile

Method used

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  • A pharmaceutical composition for treating gallbladder-related diseases, preparation method and application thereof
  • A pharmaceutical composition for treating gallbladder-related diseases, preparation method and application thereof
  • A pharmaceutical composition for treating gallbladder-related diseases, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0078] The preparation method step of oral liquid of the present invention is as follows:

[0079] Take 4.0-2.0 parts by weight of emblica, 3.2-0.5 parts by weight of myrobalan, and 2.8-0.4 parts by weight of myrobalan. After cleaning, there is no impurity, no moth, no mildew, and it is ready for use after passing the inspection.

[0080] Mix the above components, add 6-20 times the weight of water to decoct twice, each time for 1 hour, filter, combine the filtrate, put it in a vacuum concentration tank, and concentrate under reduced pressure at 60°C and 0.02mpa to a relative density of 1.10- 1. 25 (20°C) extract, add agar and honey, mix evenly, place at 4°C for 48 hours, filter, add appropriate amount of flavoring agent to the filtrate, mix evenly, add appropriate amount of bentonite, mix evenly, place at 4°C for 48 hours, and filter repeatedly , the filtrate is sent to the 100,000 clean level automatic bottling workshop for filling, 30 milliliters per bottle, sterilized, ins...

Embodiment 2

[0100] The steps of the preparation technology of capsule of the present invention are as follows:

[0101] Take 4.0-2.0 parts by weight of emblica, 3.2-0.5 parts by weight of myrobalan, and 2.8-0.4 parts by weight of myrobalan. After cleaning, there is no impurity, no moth, no mildew, and it is ready for use after passing the inspection.

[0102] Mix the above components, add 6-20 times the amount of water to decoct twice, each time for 1 hour, filter, combine the filtrate, put it in a vacuum concentration tank, and concentrate under reduced pressure at 60°C and 0.02mpa to a relative density of 1.10- 1.25 (20°C) extract, add ethanol until the ethanol content reaches 70%, mix well, let it stand overnight, filter, after the filtrate recovers ethanol, put it in a vacuum concentration tank, 60°C, 0.02mpa reduced pressure and concentrate to relative Thick paste with a density of 1.28-1.40 (20°C). Take starch, dextrin, and sugar powder (7:1:1) as auxiliary materials, mix with thic...

Embodiment 3

[0115] Embodiment 3, research on the pharmacological effectiveness of the combination of the present invention

[0116] Experiment 1. The influence of the combination of the present invention on normal bile secretion:

[0117] Guinea pigs were randomly divided into groups according to body weight, 10 in each group. Fasting without food and water for 12 hours before the experiment, the animals in each group were anesthetized with 20% urethane 1mL / 100g.bw intraperitoneally, and then the common bile duct was inserted into the silicone tube for surgery. After the operation was completed, the bile was collected and the volume of bile was measured to observe the stability of bile secretion. The test substance is mainly based on the proposed clinical dose. The equivalent dose converted into guinea pigs based on body surface area is 1.17g crude drug / kg, take 0.52g crude drug / mL SLJ oral liquid, and administer 1mL / 100g, that is, 5.2g crude drug / kg. After the bile secretion was stabl...

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Abstract

The invention discloses a medical composition for treating bile related diseases, and a preparation method and application thereof. The medical composition comprises emblic leafflower fruits, medicine terminalia fruits and belleric terminalia fruits, and is prepared into pills or oral liquids through the steps of mixing, decocting in water, compressing and the like. The medical composition shows obvious effect on inhibiting normal biliation in animal experiments, can remarkably inhibit excessive abnormal biliation, alters dynamic parameters in a biliary tract, lowers internal pressure of a gallbladder and a biliary duct, reduces resistance of Oddi sphincter muscle, reduces stimulation of bile on a wound surface of a biliary surgery and harms of bile on gastrointestinal mucosa, achieves the effects of relieving pain and promoting functional restoration, is suitable for the treatment of biliary dyskinesia which includes the biliary dyskinesia after a gallbladder resection and the biliary dyskinesia outside the chole, can remarkably relieve recurrent right upper quadrant pain, right upper quadrant pressing pain, continuous epigastric burning sensation, substernal pain and other associated symptoms, such as eructation, sour regurgitation, nausea vomit, anorexia and emaciation.

Description

technical field [0001] The present invention relates to a pharmaceutical composition, a preparation method and its use, especially a herbal medicine composition for treating digestive system diseases, a preparation method and its use, especially a pharmaceutical composition, a preparation method and its use for treating gallbladder-related diseases. use. Background technique [0002] Biliary dyskinesia refers to the fact that although there are symptoms suspected of being a biliary system disease, no organic lesion in any part of the biliary system is found through various imaging examinations, such as cholelithiasis, inflammation, tumor [James Toouli Current Treatment Options in Gastroenterology 09 / 2002; 5(4):285-291. DOI: 10.1007 / s11938-002-0051-9]. The process of bile discharge is completed by the ingenious motor regulation of the gallbladder, duct, and Oddi's sphincter. The occurrence of biliary dyskinesia is a disorder of normal motor regulation. Its clinical manifest...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/47A61P1/16A61P1/04
Inventor 李星炜莫太刚刘小军樊三虎兰明邓雪梅
Owner SICHUAN RES INST OF NATURE DRUGS
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