Fluorescent probe made of rhodamine B, diethylenetriamine and PITC (phenyl isothiocyanate) as well as preparation method and application thereof

A technology of diethylenetriamine and phenylthiourea, applied in chemical instruments and methods, fluorescence/phosphorescence, luminescent materials, etc., can solve the problems of inability to detect, low sensitivity, poor selectivity, etc., and achieve good practicability , improve the detection sensitivity, improve the effect of selectivity
CN104098581AInactive Publication Date: 2014-10-15SUZHOU UNIV

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SUZHOU UNIV
Publication Date
2014-10-15
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a fluorescent probe made of rhodamine B, diethylenetriamine and PITC (phenyl isothiocyanate) as well as a preparation method and an application thereof. Specifically, rhodamine B and diethylenetriamine react firstly to form a spiro amide structure with a stable property, a nitrogen bridging fragment is introduced, and the mixture then reacts with PITC so as to introduce a sulfur atom. By means of sulphophile affinity of mercury ions, each molecule of a novel rhodamine B-phenylthiourea derivative (namely, mercury ion fluorescent probe RDTU) obtained through the scheme can be combined with two mercury ions, so that the fluorescent probe has higher selectivity and detection sensitivity. The molecules of the fluorescent probe can perform detection in a neutral buffer solution especially in water phase. Additionally, the molecules of the fluorescent probe can detect the mercury ions from mercury chloride, and has better practicability.
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Description

technical field

[0001] The invention belongs to the field of organic synthesis, and specifically relates to a rhodamine B-phenylthiourea derivative used as a fluorescent probe material and a preparation method and application thereof. Background technique

[0002] Mercury is a heavy metal with the highest occurrence frequency and toxicity, with a wide range of influence and strong toxicity. Due to its high affinity for thiol groups in functional proteins and enzymes, mercury or its derivatives often lead to cellular dysfunction and subsequent health problems (see M. Harada, Minamata disease: methylmercury poisoning in Japan caused by environmental pollution, Crit. Rev. Toxicol. , 1962, 2:40-57). Unfortunately, mercury contamination can occur in a range of natural and man-made environments, such as tsunamis or volcanic eruptions, gold mining, and fuel oil waste. Therefore, effective detection or monitoring of mercury in biological samples or environmental samples has becom...

Claims

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