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Preparation method of biological composite material using titanium alloy as implant

A technology of composite materials and titanium alloys, applied in prosthetics, medical science, etc., can solve the problems of low bonding strength and easy falling off, and achieve the effect of improving bonding strength, realizing program control, and avoiding the loss of materials

Inactive Publication Date: 2014-11-05
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Aiming at the above defects or improvement needs of the prior art, the present invention provides a method for preparing biocomposite materials using titanium alloys as implants. Its microporous surface is implanted with biocompatible materials, thus solving the technical problems of low bonding strength and easy fall-off after implanting biocompatible materials directly on the surface of medical titanium alloy in traditional layering treatment

Method used

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  • Preparation method of biological composite material using titanium alloy as implant
  • Preparation method of biological composite material using titanium alloy as implant
  • Preparation method of biological composite material using titanium alloy as implant

Examples

Experimental program
Comparison scheme
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Embodiment 1

[0035] S1: Pretreat the medical titanium alloy substrate, which is in the form of a thin sheet with a diameter of 14mm and a thickness of 1.5mm. The substrate is successively polished with 150#, 400#, 800#, 1200# and 1500# metallographic sandpaper to remove surface oxidation membrane, followed by ultrasonic cleaning with acetone and alcohol respectively;

[0036] S2: Perform laser microporation treatment on the surface of the medical titanium alloy substrate obtained in S1, wherein the medical titanium alloy substrate obtained in S1 is placed in a 20W optical fiber laser processing platform with optomechanical integration, and its wavelength is 1.064 μm. Lens F=100mm, adjust the process parameters of laser processing, that is, the average laser power is 16W, the laser pulse width is 200ns, the laser frequency is 25KHz, the single pulse energy is 0.8mJ, and the laser action time is 0.3ms when processing a microhole. In the computer system that controls the laser processing, set...

Embodiment 2

[0041] This embodiment is the same as Embodiment 1, the difference is:

[0042]S2: Perform laser microporation treatment on the surface of the medical titanium alloy substrate obtained in S1, wherein the medical titanium alloy substrate obtained in S1 is placed in a 20W optical fiber laser processing platform with optomechanical integration, and its wavelength is 1.064 μm. Lens F=100mm, adjust the process parameters of laser processing, that is, the average laser power is 16W, the laser pulse width is 200ns, the laser frequency is 25KHz, the single pulse energy is 0.8mJ, and the laser action time is 0.7ms when processing a microhole. In the computer system that controls laser processing, set the hole spacing to 100 μm, adjust the laser processor to obtain the focal length, place the substrate at the focal point, turn on the equipment, and process, the prepared micropore diameter is 80.00 μm, and the micropore depth is 44.335 μm. Microporous medical titanium alloy with a microp...

Embodiment 3

[0044] This embodiment is the same as Embodiment 1, the difference is:

[0045] S2: Perform laser microporation treatment on the surface of the medical titanium alloy substrate obtained in S1, wherein the medical titanium alloy substrate obtained in S1 is placed in a 20W optical fiber laser processing platform with optomechanical integration, and its wavelength is 1.064 μm. Lens F=100mm, adjust the process parameters of laser processing, that is, the average laser power is 16W, the laser pulse width is 200ns, the laser frequency is 25KHz, the single pulse energy is 2.00mJ, and the laser action time is 1ms when processing a microhole. In the computer system that controls laser processing, set the hole spacing to 120 μm, adjust the laser processor to obtain the focal length, place the substrate at the focal point, turn on the equipment, and process. Microporous medical titanium alloy with hole center distance of 120 μm.

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Abstract

The invention discloses a preparation method of a biological composite material using titanium alloy as an implant. The method comprises the following steps: S1. pretreating a substrate with medical titanium alloy to clean the surface; S2. conducting laser micropore treatment on the surface of the medical titanium alloy substrate obtained in S1, wherein the parameters of laser processing are adjusted so that the medical titanium alloy substrate acquires microporous structures with different diameters, different depths and different hole pitches; S3. conducting post treatment on the microporous medical titanium alloy substrate obtained in S2 to clean the surface; and S4. conducting electrophoretic deposition on the substrate obtained in S3, wherein the electrophoretic deposition is carried out in a solution containing a biological active material. In the method, bioactive material HA and titanium alloy substrate are combined to form a rivet combinations, which firmly embed in the pores and are not easy to fall off, so as to solve the problem of easy peeling of bonded HA layer and titanium alloy.

Description

technical field [0001] The invention belongs to the technical field of biomaterials, and more specifically relates to a method for preparing biocomposite materials using titanium alloys as implants. Background technique [0002] Titanium and titanium alloys have good biocompatibility, corrosion resistance, and tissue compatibility. Compared with commonly used stainless steel and cobalt-chromium alloys, they have the advantages of light weight, mechanical properties and elastic modulus closer to natural bone , so it is often used as a metal implant material. However, implantation of titanium alloys into the human body has problems such as poor biological activity, low bonding strength, and long healing time. [0003] In order to improve the biological activity of titanium alloy and promote its combination with human bone tissue, it is necessary to carry out surface treatment on titanium alloy. The surface treatment methods include layer reduction treatment and layer addition...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/06A61L27/12A61L27/54
Inventor 王爱华孟丽娜吴宇王喜
Owner HUAZHONG UNIV OF SCI & TECH
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