A kind of preparation method of hyaluronic acid/bacterial cellulose composite hydrogel

A bacterial cellulose and composite hydrogel technology, applied in the biological field, can solve the problems of difficult water recovery, easy water extrusion, low compressive modulus, etc., and achieves difficult to be contaminated by microorganisms, good light transmittance, and low production cost. Effect
CN104130424BInactive Publication Date: 2018-06-08TIANJIN UNIV OF SCI & TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
TIANJIN UNIV OF SCI & TECH
Publication Date
2018-06-08
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a preparation method of a hyaluronic acid / bacterial cellulose composite hydrogel, which comprises taking out the bacterial cellulose membrane after bacterial fermentation, crushing the bacterial cellulose membrane, and homogenizing under high pressure to obtain the bacterial cellulose suspension , dissolving hyaluronic acid therein, adjusting the pH value to be acidic, and continuously stirring to obtain an acidic gel, then washing the gel until it is neutral, and drying it in vacuum to obtain a hyaluronic acid bacterial cellulose composite dry gel. The gel prepared by this method has a three-dimensional network structure, and the material has good light transmittance. It can be seen from Figure 2 that the dried gel retains the good light transmittance and high water content of the hyaluronic acid / bacterial cellulose composite hydrogel after rehydration , it can be seen from Figure 3 that its morphology is a typical gel feature, and the average pore size is tens of microns. It can be seen from Figure 4 that at a shear rate of 0.1-100Hz, this material behaves as an elastic body, which proves that it is here The scope has good elastic properties.
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Description

technical field

[0001] The invention belongs to the field of biotechnology, and relates to a preparation method of hyaluronic acid / bacterial cellulose composite hydrogel. technical background

[0002] In recent years, due to energy shortage and demand for environmentally friendly materials, cellulose, as a rich and renewable natural resource, has received more and more attention in the field of development and utilization of natural renewable resources. Bacterial cellulose (BC) is cellulose synthesized by certain bacteria. Although BC and plant-produced cellulose have the same molecular structure unit, unlike plant cellulose, BC has no associated products such as lignin, pectin and hemicellulose, and has high chemical purity, high crystallinity and high degree of polymerization. . It also has an ultra-fine network structure, high elastic modulus, and strong water holding capacity. BC is easy to regulate during biosynthesis. Its excellent biocompatibility, adaptability an...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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