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A kind of chitosan-based double network hydrogel and preparation method thereof

A chitosan-based double-hydrogel technology is applied in the preparation of the above-mentioned hydrogels and in the field of high-strength chitosan-based double-network hydrogels, which can solve the problem of high water content of polymer hydrogels and limit wide application. , low mechanical strength of hydrogels, etc., to achieve excellent physical properties, good light transmittance, and improve biocompatibility.

Inactive Publication Date: 2017-05-31
CHINA UNIV OF GEOSCIENCES (WUHAN)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

One of the very important reasons is that the high water content of the polymer hydrogel leads to the low mechanical strength of the hydrogel, which limits its application in the fields of drug controlled release systems, sensors, biological cell scaffolds and biological tissue engineering. widely used

Method used

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  • A kind of chitosan-based double network hydrogel and preparation method thereof
  • A kind of chitosan-based double network hydrogel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The chitosan-based double-network hydrogel provided in this embodiment has a double-network structure, wherein the first network is a chitosan-grafted hydrogel, and the chitosan-grafted hydrogel is composed of Chitosan solution, initiator, first monomer and cross-linking agent are formed by grafting reaction, the second network is interspersed inside the first network, and the second network is formed by the second monomer, cross-linking agent and photoinitiator Hydrogels polymerized under UV light irradiation.

[0026] The preparation method in this example is as follows: Dissolve 1g of chitosan in 60mL of 1% v / v dilute acetic acid solution, stir for 1h with a glass rod, so that chitosan is uniformly dispersed in the solution, and the obtained uniform dispersion is placed in Stirring was continued for 12 h in a magnetic stirrer to obtain chitosan acetic acid solution. Then place it in a constant temperature water bath at 60° C., and add 0.2 g of initiator ammonium per...

Embodiment 2

[0030] The chitosan-based double-network hydrogel provided in this embodiment has a double-network structure, wherein the first network is a chitosan-grafted hydrogel, and the chitosan-grafted hydrogel is composed of Chitosan solution, initiator, first monomer and cross-linking agent are formed by grafting reaction, the second network is interspersed inside the first network, and the second network is formed by the second monomer, cross-linking agent and photoinitiator Hydrogels polymerized under UV light irradiation.

[0031] The preparation method in this example is as follows: Dissolve 1g of chitosan in 60mL of 1% v / v dilute acetic acid solution, stir for 1h with a glass rod, so that chitosan is uniformly dispersed in the solution, and the obtained uniform dispersion is placed in Stirring was continued for 12 h in a magnetic stirrer to obtain chitosan acetic acid solution. Then place it in a constant temperature water bath at 60° C., and add 0.3 g of initiator potassium pe...

Embodiment 3

[0035] The chitosan-based double-network hydrogel provided in this embodiment has a double-network structure, wherein the first network is a chitosan-grafted hydrogel, and the chitosan-grafted hydrogel is composed of Chitosan solution, initiator, first monomer and cross-linking agent are formed by grafting reaction, the second network is interspersed inside the first network, and the second network is formed by the second monomer, cross-linking agent and photoinitiator Hydrogels polymerized under UV light irradiation.

[0036]The preparation method in this example is as follows: Dissolve 1g of chitosan in 60mL of 1% v / v dilute acetic acid solution, stir for 1h with a glass rod, so that chitosan is uniformly dispersed in the solution, and the obtained uniform dispersion is placed in Stirring was continued for 12 h in a magnetic stirrer to obtain chitosan acetic acid solution. Then place it in a constant temperature water bath at 60° C., and add 0.4 g of initiator potassium per...

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Abstract

The invention provides chitosan-based double-network hydrogel. The hydrogel is of a double-network structure. A first network is chitosan graft hydrogel, and the chitosan graft hydrogel is formed by chitosan liquid, an initiator, a first single body and a cross-linking agent through grafting reaction. A second network is inserted inside the first network, and the second network is hydrogel which is formed by polymerization of a second single body, a cross-linking agent and a photo-initiator under the radiation of ultraviolet light and has high compression strength and tensile strength. Due to the introduction of chitosan, the biocompatibility of the hydrogel is improved. Thus, application of the double-network hydrogel in the fields such as biological medicine, the construction industry, the chemical industry and the mining industry is improved. The invention further provides a preparation method for preparing the chitosan-based double-network hydrogel. The method is simple in technology and enables industrialization to be easy.

Description

technical field [0001] The invention provides a high-strength chitosan-based double-network hydrogel, which belongs to the field of hydrogel technology, and also provides a preparation method of the hydrogel. Background technique [0002] Polymer hydrogel is a kind of moderately cross-linked polymer network system that contains rich hydrophilic groups and can absorb water and swell in aqueous solution without dissolving in water. As a material with high water absorption and high water retention, polymer hydrogel is widely used in the fields of physiological care, agriculture, forestry and gardening, daily chemical industry, construction engineering and environmental protection. In addition, the polymer hydrogel in swelling balance also has a certain mechanical strength. This material is similar to the cartilage tissue in the living body, flexible and elastic. Therefore, it is considered to be a very suitable replacement for human cartilage tissue. Materials have great appli...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08L51/02C08L33/26C08L33/24C08F251/00C08F220/56C08F220/54C08F222/38C08J3/075
Inventor 曾鸣刘建新李然然许清强
Owner CHINA UNIV OF GEOSCIENCES (WUHAN)