Method for performing modification of chitosan or derivative thereof on surface of medical polyurethane material

A polyurethane material, chitosan technology, applied in the field of modification of chitosan or its derivatives, can solve problems such as insoluble in aqueous solution, poor mechanical processing performance, etc., and achieve the effect of easy control of reaction conditions, high difficulty and simple process

Active Publication Date: 2014-11-19
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chitosan is the only natural alkaline polysaccharide that exists in nature. It has good biocompatibility, degradability, non-irritation, non-immunogenicity and non-pyrogenic reaction, but its mechanical processing performance is poor and it is difficult to dissolve in aqueous solution.

Method used

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  • Method for performing modification of chitosan or derivative thereof on surface of medical polyurethane material
  • Method for performing modification of chitosan or derivative thereof on surface of medical polyurethane material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Graft chitosan on the surface of medical polyurethane material, and use Jones reagent for surface oxidation treatment

[0036] Measure 30ml of Jones reagent, put the washed and dried 0.5g (2cm*2cm) polyurethane film material into Jones reagent for 4h reaction. After the reaction was completed, the polyurethane film material was taken out and washed for 10 minutes, then placed in a 3 wt % carbodiimide solution for 8 hours, washed and dried. Prepare 50ml chitosan solution of 5wt% in a three-necked flask, put it into an oil bath with a temperature of 55° C., and under magnetic stirring, firstly add polyurethane film material into the reaction system, and pass into nitrogen protection. 1 ml of acrylic acid solution with a concentration of 95 wt% was slowly dropped into the reaction system with a dropper. The reaction time is 8h. After the grafting reaction, wash in hot water at about 60°C for 8 hours, change the water every 2 hours, and then ultrasonically clean with etha...

Embodiment 2

[0039] Grafting carboxymethyl chitosan on the surface of medical polyurethane material, and using Jones reagent for surface oxidation treatment

[0040] Measure 50ml of Jones reagent, put the cleaned and dried polyurethane catheter material with a length of 4cm in Jones reagent for 2h. After the reaction was completed, the polyurethane conduit material was taken out and cleaned for 20 minutes, then placed in a 2 wt % carbodiimide solution for 7 hours, washed and dried. Prepare 50ml carboxymethyl chitosan solution of 8wt% in a three-necked flask, put it into an oil bath at a temperature of 55° C., and under magnetic stirring, firstly add the polyurethane catheter material into the reaction system, and pass it into the nitrogen protection. 1 ml of acrylic acid solution with a concentration of 95 wt% was slowly dropped into the reaction system with a dropper. The reaction time is 8h. After the grafting reaction, wash in hot water at about 60°C for 8 hours, change the water ever...

Embodiment 3

[0043] Grafting phosphorylcholine chitosan derivatives on the surface of medical polyurethane materials, and using ozone for surface oxidation treatment

[0044] The cleaned and dried polyurethane catheter material with a length of 4 cm was activated in ozone with a concentration of 20 mg / L for 40 min. After the reaction was completed, the polyurethane conduit material was taken out and placed in a 5 wt % carbodiimide solution for 9 hours of reaction, washed and dried. Prepare 50ml phosphorylcholine chitosan derivative solution of 5wt% in a three-necked flask, put it into an oil bath with a temperature of 60°C, and under magnetic stirring, firstly add the polyurethane catheter material into the reaction system, and pass it into the nitrogen protection. Slowly drop 1 ml of 95% acrylic acid solution into the reaction system with a dropper. The reaction time is 12h. After the grafting reaction, wash in hot water at about 50°C for 12 hours, change the water every 2 hours, and th...

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Abstract

The invention discloses a method for performing modification of chitosan or a derivative thereof on the surface of a medical polyurethane material. The method comprises the steps that: the medical polyurethane material is cleaned and dried; an oxidation treatment is carried out upon a clean surface of the medical polyurethane material, wherein the oxidation treatment includes Jones reagent, ozone or ultraviolet irradiation treatment; the medical polyurethane material obtained after oxidation treatment is placed in a 2-5wt% carbodiimid solution, and a reaction is allowed for 7-9h; washing and drying are carried out; the obtained medical polyurethane material is placed into a solution of chitosan or a derivative thereof, such that a grafting reaction is carried out; the grafted medical polyurethane material is cleaned by washing, and is subjected to vacuum drying, such that a medical polyurethane material with chitosan or chitosan derivative modification on the surface is obtained. The method provided by the invention has the characteristics of easy-to-control reaction conditions, simple procedure, easy-to-enlarge process, and the like. The obtained material has good hydrophilicity and biocompatibility.

Description

technical field [0001] The invention relates to the technical field of medical polymer materials, in particular to a method for modifying the surface of medical polyurethane materials with chitosan or its derivatives. Background technique [0002] Medical-grade polyurethane has unique properties, such as relatively excellent biocompatibility, chemical properties, mechanical properties, and processing properties, making it an ideal choice for many medical products. Especially when materials need to solve complex mechanical properties and biocompatibility problems at the same time, polyurethane is the most commonly used choice, such as polyurethane is prepared for interventional catheters, coatings for interventional devices, artificial hearts, interventional balloons, ventricular assisted circulatory systems, cardiac Blood-contacting devices such as valves and hemodialysis membranes. However, most medical-grade polyurethanes are hydrophobic. Although their microphase separat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F291/00C08B37/00
Inventor 周雪锋钱玲顾宁张天柱
Owner SOUTHEAST UNIV
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