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Method for preparing fermented traditional Chinese medicinal fever-clearing and toxicity-eliminating powder

A technology of Qingwen Baidu powder and fermentation type, which is applied in pharmaceutical formulations, medical preparations containing active ingredients, antibacterial drugs, etc., can solve the problem that the efficacy of drugs cannot be fully exerted, the active ingredients are difficult to dissolve, and the utilization rate of drugs is low. and other problems, so as to make up for the low bioavailability, improve the anti-stress ability, and have a good therapeutic effect.

Inactive Publication Date: 2014-12-03
河南亚卫动物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The traditional method of using Qingwenbaidu powder is to crush the traditional Chinese medicine and feed it directly. The preparation process is simple, but due to the large particle size of the medicine, there are many active ingredients that are difficult to dissolve, resulting in a low utilization rate of the medicine. cannot be fully utilized

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] A preparation method of fermented traditional Chinese medicine Qingwenbaidu Powder, comprising the steps of:

[0019] 1) Take the raw materials of Qingwenbaidu powder in proportion, grind them, mix them evenly, and pass through an 80-mesh sieve for later use;

[0020] 2) Inoculate Lactobacillus delbrueckii subsp. bulgaricus GIM1.204 in MRS medium, and culture it on a shaker (150r / min) at 30°C for 18 hours to obtain fermentation strains, and set aside;

[0021] 3) Sterilize the traditional Chinese medicine powder obtained in step 1) at 121°C for 15 minutes, then mix the fermented bacteria with sterile water (the amount of sterile water is 1.5 times the total weight of the traditional Chinese medicine powder) and then use 10% inoculation amount Inoculate it into traditional Chinese medicine powder and culture it for anaerobic fermentation at 30°C for 5 days, stirring once every 12 hours. After the fermentation and cultivation, air-dry the fermentation product at 40°C.

Embodiment 2

[0023] A preparation method of fermented traditional Chinese medicine Qingwenbaidu Powder, comprising the steps of:

[0024] 1) Take the raw materials of Qingwenbaidu powder in proportion, grind them, mix them evenly, and pass through an 80-mesh sieve for later use;

[0025] 2) Inoculate brewer's yeast ATCC 9763 into PDA medium, and culture it on a shaking table (120r / min) at 25°C for 18 hours to obtain fermentation strains, and set aside;

[0026] 3) Sterilize the traditional Chinese medicine powder obtained in step 1) at 121°C for 15 minutes, then mix the fermented bacteria with sterile water (the amount of sterile water is twice the total weight of the traditional Chinese medicine powder), and then use 18% inoculation amount Inoculate it into traditional Chinese medicine powder and culture it for anaerobic fermentation at 25°C for 7 days, stir once every 12 hours, and dry the fermentation product at 40°C after the fermentation is completed.

Embodiment 3

[0028] A preparation method of fermented traditional Chinese medicine Qingwenbaidu Powder, comprising the steps of:

[0029] 1) Take the raw materials of Qingwenbaidu powder in proportion, grind them, mix them evenly, and pass through an 80-mesh sieve for later use;

[0030] 2) Inoculate Bacillus subtilis ATCC 6633 in the nutrient broth medium, and culture it on a shaker (120r / min) at 32°C for 24 hours to obtain the fermentation strain, and set aside;

[0031] 3) Sterilize the traditional Chinese medicine powder obtained in step 1) at 121°C for 15 minutes, then mix the fermented bacteria with sterile water (the amount of sterile water is twice the total weight of the traditional Chinese medicine powder), and then use 8% inoculation amount Inoculate it into traditional Chinese medicine powder and culture it for anaerobic fermentation at 32°C for 3 days, stir once every 12 hours, and dry the fermentation product at 40°C after the fermentation is completed.

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Abstract

The invention relates to a method for preparing fermented traditional Chinese medicinal fever-clearing and toxicity-eliminating powder. The method comprises the following steps: (1) weighing the traditional Chinese medicinal materials according to a proportion, grinding and uniformly mixing, and screening for later use; (2) inoculating a strain in a liquid culture medium, and culturing in a shaker at 20-40 DEG C for 18-24 hours to obtain a fermented strain for later use, wherein the strain is one or more than two of bacillus subtilis, saccharomyces cerevisiae and lactobacillus bulgaricus; (3) sterilizing the traditional Chinese medicinal powder obtained in the step (1) at 110-130 DEG C for 10-30 minutes, uniformly mixing the fermented strain and sterile water, and inoculating the mixture into the traditional Chinese medicinal powder, performing anaerobic fermentation culture for 2-7 days at 20-40 DEG C, stirring once every 12 hours, and drying the fermented product after the fermentation culture is finished. Clinical tests discover that the fermented traditional Chinese medicinal fever-clearing and toxicity-eliminating powder has a good effect on preventing and treating pestilent maculae and hyperpyretic coma, is remarkable in curative effect, convenient to use, small in toxic and side effect and green and has no residue.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a preparation method of a fermented traditional Chinese medicine Qingwenbaidu powder for treating infectious diseases of livestock and poultry. Background technique [0002] With the rapid development of my country's social economy and the continuous improvement of people's living standards, people's awareness of healthy living is also gradually increasing. Therefore, the production of safe and high-quality livestock products is particularly important. The extensive use of antibiotics, chemically synthesized drugs and hormone drugs in feed has brought great harm to breeding production, affecting food safety and people's health. As the treasure of Chinese medicine, Chinese herbal medicine has dual functions of nutrition, health care and disease treatment. However, Chinese herbal medicine also has many defects, such as poor absorption and utiliza...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61P31/04A61K35/32A61K33/06
Inventor 唐洪峰张遂平郭芳茹吴胜耀苑青艳刘冬梅王菊萍李燕刘诗柱刘静杨果张海涛
Owner 河南亚卫动物药业有限公司
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