Compounded traditional Chinese medicinal rana chensinensis extract preparation and application thereof in preparation of medicine for treating and preventing dermatophytosis

A compound preparation and traditional Chinese medicine technology, which is applied in the field of preparation of medicines for the treatment and prevention of beriberi, and the compound preparation of traditional Chinese medicines extracted from Rana lindens, can solve the problems of beriberi being difficult to cure, difficult to cure, and repeated attacks of beriberi, so as to achieve rapid disappearance of clinical symptoms and improve defense. Ability, small effect of toxic and side effects

Inactive Publication Date: 2014-12-03
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The main reason why beriberi is not easy to cure is that these fungi have strong drug resistance. During the treatment process, the moist and anaerobic environment of the affected area is a strong breeding ground for the remaining fungi; at the same time, the patient's body contains fungi. When the drug is stopped, the fungus in the body can continue to multiply, resulting in repeated outbreaks of beriberi, which is difficult to cure

Method used

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  • Compounded traditional Chinese medicinal rana chensinensis extract preparation and application thereof in preparation of medicine for treating and preventing dermatophytosis
  • Compounded traditional Chinese medicinal rana chensinensis extract preparation and application thereof in preparation of medicine for treating and preventing dermatophytosis
  • Compounded traditional Chinese medicinal rana chensinensis extract preparation and application thereof in preparation of medicine for treating and preventing dermatophytosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] Example 1 Preparation of Rana Rana Extract Compound Chinese Medicine Preparation

[0063] (1) Preparation of Rana extract mixture

[0064] Take 40g of dried forest frog (Chinese forest frog Changbai Mountain subspecies, purchased from Jilin Pharmacy), and after removing impurities and dust, grind it through 20 mesh, 50 mesh, and 100 mesh respectively, so that the particle size of the dried wood frog pulverization is below 500 μm, according to Add the compound enzyme hydrolyzate at the ratio of 1g:6mL, the compound enzyme hydrolyzate contains papain 3wt%, trypsin 2wt%, flavor protease 1wt%, enzymolysis temperature is 52℃, enzymolysis time is 1.5h, enzymolysis pH is 7.2, then inactivate the enzyme at 87°C for 10 minutes, centrifuge the mixture at a temperature of 25°C for 3 minutes and at a speed of 2500 rpm, take 25% of the total volume of the supernatant, and extract the Rana dry short peptide collagen;

[0065] The content of arginine, lysine and histidine in the col...

Embodiment 2

[0074] Example 2 Preparation of Rana Rana Extract Traditional Chinese Medicine Compound Ointment

[0075] (1) Preparation of compound preparation of Chinese medicine extracted from forest frog

[0076] Take by weighing 40g of dried forest frog (Chinese forest frog Changbai Mountain subspecies, purchased from Jilin Pharmacy), 29g of ash (purchased from Chengdu Pharmacy), 2g of Galla chinensis, 1g of Sophora flavescens, 1g of purslane, 2g of Fructus Cnidii, 1g of Phellodendron Phellodendri , perilla 1g, mint leaves 2g, notopterygium 1g, Fangji 1g, Sichuan pepper 2g, atractylodes 3g, white ringworm skin 1g, berberine 1g, Kochia chinensis 1g, 1g basil, safflower 1g, Huoxiang 1g (above 17 Flavored traditional Chinese medicines were all purchased from Jilin Pharmacy), and the compound preparation of Chinese medicine extracted from Rana Rana was prepared according to the method of Example 1, and the volume was 175mL.

[0077] (2) Preparation of oil phase: get 8g of paraffin, 6g of l...

Embodiment 3

[0079] Example 3 Preparation of Rana Rana Extract Traditional Chinese Medicine Compound Spray

[0080] (1) Preparation of compound preparation of Chinese medicine extracted from forest frog

[0081] Get dried Rana 40g (Chinese Rana Changbai Mountain subspecies, purchased from Jilin Da Pharmacy), 29g Glycyrrhizae chinensis (purchased from Chengdu Pharmacy), Galla chinensis 2g, Sophora flavescens 1g, Purslane 1g, Fructus Cnidii 2g, Phellodendron Phellodendri 1g, 1g Perilla, 2g Mint Leaf, 1g Notopterygium, 1g Fangji, 2g Chuanjiao, 3g Atractylodes, 1g Baizhenpi, 1g Huhuanglian, 1g Kochia, 1g Baibu, 1g Safflower, 1g Huoxiang (the above 17 flavors All the traditional Chinese medicines were purchased from Jilin Pharmacy), and the compound preparation of Chinese medicine extracted from forest frog was prepared according to the method of Example 1, with a volume of 175 mL.

[0082] (2) Preparation of Rana Rana Extract Traditional Chinese Medicine Compound Spray

[0083] Adding PEG4 t...

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Abstract

The invention relates to a compounded traditional Chinese medicinal rana chensinensis extract preparation and an application thereof in preparation of a medicine for treating and preventing dermatophytosis, and belongs to the technical field of traditional Chinese medicine preparations. The preparation method of the preparation comprises the following steps: removing impurities and dust from dried rana chensinensis and then smashing, adding a compound enzyme hydrolysate and centrifuging to obtain a supernate at an upper layer; grinding the rest of mixtures, then shearing and carrying out spray drying to form powder, adding the supper micropowder into an acetic acid and carrying out ultrasonic treatment, then filtering the micropowder with a gauze and centrifuging to obtain a supernate, and carrying out reduced pressure concentration on the supernate so as to obtain a mixture of polysaccharides, antibacterial peptides and calcium ions; mixing the mixtures so as to obtain a mixed rana chensinensis extracting liquid; fully mixing the mixed rana chensinensis extracting liquid with a compounded medicine extracting liquid so as to obtain the compounded traditional Chinese medicinal rana chensinensis extract preparation. The obtained preparation is a traditional Chinese medicinal preparation without any side effects, wherein short peptide collagens contained in the preparation can favorably enter normal cells under the action of polysaccharides of a fungus plant growing from the head part of an old tea tree with parasitical calanthe japonica blume so as to supply sufficient nutrition to the cells and restore the injured cells, and the antibacterial peptides can be combined with the calcium ions so as to enhance the damage of the short peptide collagens to the cytoderm of fungal cells, so that the effective bactericidal components of traditional Chinese medicines can enter the fungal cells to reach a bactericidal effect.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and in particular relates to a compound preparation of traditional Chinese medicine extracted from forest frogs and its application in preparing medicines for treating and preventing beriberi. Background technique [0002] Athlete's foot is a very common skin disease. 70-80% of adults suffer from beriberi, but the severity is different. It is often aggravated in summer and alleviated in winter, and some people do not heal all the year round. The pathogenic bacteria are mostly Trichophyton and Epidermophyton species, the main species are Trichophyton rubrum, Trichophyton gypsum, Epidermophyton flocculus, Trichophyton rosea. The main reason why beriberi is not easy to cure is that these fungi have strong drug resistance. During the treatment process, the moist and anaerobic environment of the affected area is a strong breeding ground for the remaining fungi; at t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/904A61K9/06A61K9/12A61K8/98A61K8/97A61P31/10A61P17/00A61Q19/10A61K35/64A61K35/56
Inventor 刘艳滕乐生孟庆繁王迪付珧逯家辉李佺李喆张杰刘瑜滕利荣孟令军
Owner JILIN UNIV
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