Hydroxyapatite and preparation method thereof

A technology of hydroxyapatite and aqueous solution, which is applied in the field of biomedicine, can solve the problems of limited calcium salt reagents and the inability to meet the clinical needs of hydroxyapatite, and achieve pollution problems, good social and economic benefits, and a wide range of sources Effect

Inactive Publication Date: 2014-12-17
SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] In view of this, it is necessary to provide a kind of hydroxyapatite and its preparation method to solve the problem that the calcium salt reagent is limited and cannot meet the clinical needs of hydroxyapatite

Method used

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  • Hydroxyapatite and preparation method thereof
  • Hydroxyapatite and preparation method thereof

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preparation example Construction

[0026] Such as figure 1 Shown, the preparation method of the hydroxyapatite of one embodiment, comprises the following steps:

[0027] Step S110: Pulverize discarded marine shells to obtain shell powder.

[0028] Among them, the main component of the shell is calcium carbonate, and the source of the shell is abundant and the price is low. Using discarded marine shells as raw materials, making full use of resources, is very environmentally friendly and in line with sustainable development strategies.

[0029] Wherein, the discarded marine shells may be oyster shells, clam shells, abalone shells, scallop shells or mussel shells.

[0030] Preferably, before the discarded marine shells are crushed, the step of cleaning and drying the discarded marine shells is also included: the discarded marine shells are soaked in an aqueous solution of 5% sodium hypochlorite by mass percentage, and then deionized Rinse with water, then dry. The organic matter in the shells is removed by imm...

Embodiment 1

[0049] The preparation method of the hydroxyapatite of the present embodiment is as follows:

[0050](1) Soak discarded oyster shells in an aqueous solution of 5% sodium hypochlorite for 1 hour, then wash them with deionized water for 3 times, and then air dry them naturally. The oyster shell is crushed mechanically to obtain the oyster shell powder.

[0051] (2) Pass the oyster shell powder through a 400-mesh sieve, then weigh 10 g of oyster shell powder and dissolve it in 1 L of 0.2 mol / L nitric acid aqueous solution, place it on a magnetic stirrer and stir for 10 minutes to obtain 0.1 mol / L Calcium ion solution.

[0052] (3) Weigh 13.2 g of diamine hydrogen phosphate, dissolve it in 500 mL of deionized water, and place it on a magnetic stirrer to stir for 10 minutes to obtain a 0.2 mol / L aqueous solution of diamine hydrogen phosphate.

[0053] (4) According to the molar ratio of calcium element and phosphorus element being 5:3, mix the calcium ion solution in step (2) wit...

Embodiment 2

[0056] The preparation method of the hydroxyapatite of the present embodiment is as follows:

[0057] (1) Soak discarded clam shells in an aqueous solution of 5% sodium hypochlorite for 1 hour, then wash them with deionized water for 3 times, and then air dry them naturally. The clam shell is crushed mechanically to obtain the clam shell powder.

[0058] (2) Pass the clam shell powder through a 200-mesh sieve, then weigh 1g of clam shell powder and dissolve it in 1L of 0.02mol / L hydrochloric acid aqueous solution, place it on a magnetic stirrer and stir for 10 minutes to obtain 0.01mol / L L calcium ion solution.

[0059] (3) Weigh 0.71 g of sodium hydrogen phosphate, dissolve it in 500 mL of deionized water, and place it on a magnetic stirrer to stir for 10 minutes to obtain a 0.01 mol / L aqueous solution of sodium hydrogen phosphate.

[0060] (4) According to the molar ratio of calcium element and phosphorus element of 5:3, mix the calcium ion solution in step (2) with the aq...

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Abstract

The invention discloses a preparation method of hydroxyapatite. The preparation method comprises the following steps of crushing waste sea shells to obtain shell powder, dissolving the shell powder in an acidic solution to obtain a calcium ion solution having a concentration of 0.01-0.5mol/L, mixing the calcium ion solution and a phosphate aqueous solution according to a mole ratio of calcium to phosphorus of 5: 3 to obtain a mixed solution, adjusting a pH value of the mixed solution to 8-10 by ammonia water, putting the treated mixed solution into a reactor, and carrying out a hydrothermal reaction process at a temperature of 100-200 DEG C for 2-12h to obtain hydroxyapatite. The preparation method of the hydroxyapatite can effectively solve the problem that the amount of a calcium salt reagent is limited and cannot satisfy hydroxyapatite clinical demand. The invention also provides the hydroxyapatite.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to a hydroxyapatite and a preparation method thereof. Background technique [0002] Hydroxyapatite (Hydroxyapatite, hereinafter referred to as HAP) accounts for about 72% of the bone composition, and as high as 95% in the dental bone. It is the main mineral component of human and animal bones and teeth, and has good biocompatibility And biological activity, and non-toxic side effects, should be widely used as bone tissue repair and replacement materials. Compared with traditional micro-hydroxyapatite, nano-hydroxyapatite has a larger specific surface area and higher surface energy, so it has better biological activity, and also shows higher degradability and absorbability. It is a biological material with better performance. [0003] Natural hydroxyapatite does not occur in nature. At present, the hydroxyapatite powder used in the biomedical field is mainly obtained through...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B25/32B82Y30/00
Inventor 葛永梅唐斌
Owner SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
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