A kind of moxifloxacin hydrochloride ear drops and preparation method thereof

A technology of moxifloxacin hydrochloride and ear drops, applied in the field of medicine, can solve the problems of poor treatment effect, low bioavailability, poor adhesion of medicinal liquid, etc., and achieves improvement of wound surface appearance, low bioavailability, and antibacterial efficacy. strong effect

Active Publication Date: 2017-12-12
NANJING YOUKE BIOLOGICAL MEDICAL RES +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] The object of the present invention is to provide a kind of compound moxifloxacin ear drops, which contains the medicinal ingredients of moxifloxacin hydrochloride, budesonide and ambroxol, which can strongly resist various bacteria or fungi, anti-inflammatory and anti-inflammatory effects. Allergies, the synergistic therapeutic effect of promoting the discharge of secretions and sucking pus, etc., and at the same time exerted its advantages of in-situ adhesion as instant gel drops, which is convenient for accurate control of the amount of liquid used, improves bioavailability, and overcomes the The antibacterial spectrum of ordinary ear drops in clinical application is narrow, and the therapeutic effect is not good;

Method used

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  • A kind of moxifloxacin hydrochloride ear drops and preparation method thereof
  • A kind of moxifloxacin hydrochloride ear drops and preparation method thereof
  • A kind of moxifloxacin hydrochloride ear drops and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] The prescription is as follows:

[0049] Moxifloxacin Hydrochloride 0.3%

[0050] Budesonide 0.05%

[0051] Ambroxol 0.2%

[0052] Carbomer-941 0.5%

[0053] Polyethylene glycol 2K 0.4%

[0054] Triethanolamine 0.4%

[0055] Borneol 0.2%

[0056] Menthol 0.2%

[0057] Glycerin 25%

[0058] Appropriate amount of 2.5% borax solution, adjust the pH value to 5.0-5.5;

[0059] The balance is water for injection.

[0060] Preparation method: The following materials are fed according to the prescription quantity

[0061] (1) Dissolve polyethylene glycol 2K in an appropriate amount of water for injection and set aside;

[0062] (2) Sprinkle Carbomer-941 on the surface of glycerin, use grinding method to fully infiltrate Carbomer and glycerin, add appropriate amount of water for injection and grind until fine, then add water for injection to make it fully swell; under stirring conditions , slowly adding the mixed solution of carbomer into the polyethylene glycol aqueo...

Embodiment 2

[0068] The prescription is as follows:

[0069] Moxifloxacin Hydrochloride 0.5%

[0070] Budesonide 0.08%

[0071] Ambroxol 0.3%

[0072] Carbomer-941 1.0%

[0073] Polyethylene glycol 2K 1.5%

[0074] Triethanolamine 0.6%

[0075] Borneol 0.3%

[0076] Menthol 0.3%

[0077] Glycerin 30%

[0078] Appropriate amount of 2.5% borax solution, adjust the pH value to 5.0-5.5;

[0079] The balance is water for injection.

[0080] Preparation method: The following materials are fed according to the prescription quantity

[0081] (1) Dissolve polyethylene glycol 2K in an appropriate amount of water for injection and set aside;

[0082] (2) Sprinkle Carbomer-941 on the surface of glycerin, use grinding method to fully infiltrate Carbomer and glycerin, add appropriate amount of water for injection and grind until fine, then add water for injection to make it fully swell; under stirring conditions , slowly adding the mixed solution of carbomer into the polyethylene glycol aqueo...

Embodiment 3

[0088] The prescription is as follows:

[0089] Moxifloxacin Hydrochloride 0.4%

[0090] Budesonide 0.06%

[0091] Ambroxol 0.2%

[0092] Carbomer-941 0.8%

[0093] Polyethylene glycol 2K 1.0%

[0094] Triethanolamine 0.5%

[0095] Borneol 0.3%

[0096] Menthol 0.3%

[0097] Glycerin 28%

[0098] Appropriate amount of 2.5% borax solution, adjust the pH value to 5.0-5.5;

[0099] The balance is water for injection.

[0100] Preparation method: The following materials are fed according to the prescription quantity

[0101] (1) Dissolve polyethylene glycol 2K in an appropriate amount of water for injection and set aside;

[0102] (2) Sprinkle Carbomer-941 on the surface of glycerin, use grinding method to fully infiltrate Carbomer and glycerin, add appropriate amount of water for injection and grind until fine, then add water for injection to make it fully swell; under stirring conditions , slowly adding the mixed solution of carbomer into the polyethylene glycol aqueo...

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Abstract

The invention discloses moxifloxacin hydrochloride in-situ gel ear drops. The ear drops are prepared from components such as moxifloxacin hydrochloride used as a main medicine ingredient, budesonide and ambroxol which are used as auxiliary medicines as well as carbomer, polyethylene glycol, menthol, borneol, boric acid and the like which are additionally added. The invention further discloses a preparation method of the moxifloxacin hydrochloride in-situ gel ear drops. The moxifloxacin hydrochloride is a broad-spectrum antibiotic of the fourth generation of quinolones, can perform sterilization effectively and is lasting in effect; the gel ear drops can act on affected parts directly, and the dosage is reduced, so that adverse reactions caused by whole body absorption are reduced, and the patient compliance is improved. The budesonide and the ambroxol are combined for use, so that inflammatory reactions and immunity suppression effects of mucosae can be reduced, discharge of otitis media hydrops and secretions is promoted, and the synergistic effect of eliminating etiologies and restoring functions is realized.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to an externally used medicine for treating ear infection and a preparation method thereof. Background technique [0002] Moxifloxacin is an 8-methoxyfluoroquinolone antibacterial drug. It not only has the activity of fluoroquinolones against Gram-negative bacteria, but also its C-7 nitrogen bicyclic structure strengthens the anti-Gram-positive bacteria. , in which the 8-methoxy group enhances the antibacterial activity against anaerobic bacteria while minimizing phototoxicity and cytotoxicity. The activity of moxifloxacin against streptococcus is 4 to 64 times that of levofloxacin and ciprofloxacin, and the activity against Staphylococcus aureus and Staphylococcus epidermidis is 4 to 8 times that of levofloxacin and 8 to 16 times that of ciprofloxacin. Due to its broad antibacterial spectrum, strong antibacterial activity, small adverse reactions, and almost no phototoxicity, mox...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/58A61K9/08A61K47/32A61P31/04A61P31/10A61P27/16A61K31/4709A61K31/137
Inventor 闵涛张峰朱素华薛峪泉陆晨光钱剑锋梁静
Owner NANJING YOUKE BIOLOGICAL MEDICAL RES
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