Preparation method and application of dummy template molecularly imprinted polymer

A technology that replaces templates and molecular imprinting. It is used in chemical instruments and methods, material separation, and material analysis. It can solve problems such as template leakage and inaccuracy, and achieve high-efficiency detection and ultra-high specific selectivity.

Inactive Publication Date: 2014-12-31
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report of using bisphenol S as a substitute template for the preparation of molecularly imprinted polymers of bisphenol endocrine disruptors. The bisphenols substitute template molecularly imprinted polymers prepared by this method have comparable or better selectivity, and solve the problem of inaccurate results caused by template leakage

Method used

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  • Preparation method and application of dummy template molecularly imprinted polymer
  • Preparation method and application of dummy template molecularly imprinted polymer

Examples

Experimental program
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Effect test

Embodiment 1

[0023] Dissolve 1 mmol of the surrogate template molecule bisphenol S into acetonitrile (5.6 mL) to prepare a pre-polymerization solution, place the mixture in an ice bath for 10-15 minutes of ultrasonic mixing, then pass nitrogen gas for 10 minutes to remove the oxygen in the system, seal it and refrigerate it at 4°C for 2 hours, then place it at 60°C for 24 hours . The white massive polymer produced by the reaction is pulverized, ground, sieved and settled to obtain a polymer with a particle size of 45-63 μm. The obtained polymer was subjected to Soxhlet extraction using methanol acetic acid (9:1, v / v) and methanol as extraction solvents in order to remove template molecules and other interfering substances, and the obtained polymer was dried in a vacuum oven at 60°C A white molecularly imprinted polymer (MIP) was obtained overnight.

[0024] A control non-imprinted polymer (NIP) was prepared and treated the same as above except that no template molecules were added. The ...

Embodiment 2

[0030]Dissolve 1 mmol of the surrogate template molecule bisphenol S into acetonitrile (5.6 mL) containing 4 mmol of the functional monomer methacrylic acid, 20 mmol of the crosslinker ethylene glycol-based dimethacrylate, and 0.04 g of the initiator azobisisobutyronitrile Prepare a pre-polymerization solution in an ice bath, put the mixed solution in an ice bath for 10-15 minutes and mix it uniformly, then pass nitrogen gas for 10 minutes to remove the oxygen in the system, seal it and refrigerate it at 4°C for 2h, then place it at 60°C for 24h. The white massive polymer produced by the reaction is pulverized, ground, and sieved to obtain a polymer with a particle size of 45-63 μm. The obtained polymer was sequentially Soxhlet extracted using methanol acetic acid (9:1, v / v) and methanol as the extraction solvent to remove template molecules and interfering substances, and the obtained polymer was dried overnight in a vacuum oven at 60°C A white molecularly imprinted polymer w...

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Abstract

The invention provides a preparation method and an application method of a dummy template molecularly imprinted polymer selectively enriching bisphenol endocrine disruptors. The preparation method comprises the following steps: dissolving dummy template molecules, a crosslinking agent, a functional monomer and an initiator in a pore forming solvent to prepare a pre-polymerization solution, carrying out a polymerization reaction at 50-70DEG C for 24-48h; and grinding a white block polymer generated through the polymerization reaction, sieving, settling to obtain polymer particles with the particle size of 45-63[mu]m, carrying out soxhlet extraction or ultrasonic extraction with methanol/acetic acid and methanol as an extraction solvent, and removing residual template molecules and unreacted substances in order to obtain the dummy template molecularly imprinted polymer. The invention also provides a solid phase extraction filler. The filler is the dummy template molecularly imprinted polymer. The dummy template molecularly imprinted polymer has very strong specific selectivity and enrichment ability to bisphenol F, bisphenol E, bisphenol A, bisphenol B, bisphenol AF, tetrabromobisphenol A and other bisphenol compounds, solves the template bleeding problem during trace analysis, and realizes the rapid, senseitive, accurate and efficient detection of the bisphenol endocrine disruptors in environment, foods and biological samples.

Description

technical field [0001] The invention relates to an alternative template molecularly imprinted polymer for selectively enriching and purifying bisphenol endocrine disruptors and its preparation and application, belonging to the fields of environmental monitoring and new materials. Background technique [0002] Bisphenols are widely used raw materials or additives in polymer materials. Bisphenols may be released during the production, manufacture, and use of materials. Studies have shown that bisphenols have gene mutagenesis and estrogen interference (Environ.Toxicol.17 (2002) 80; Environ.Toxicol.Pharmacol.19 (2005) 121). Among them, bisphenol A is the raw material of polycarbonate, epoxy resin and phenolic resin, and is also an important material for anti-oxidation and stabilization treatment in surgical repair, and is widely used in food packaging and container inner wall coating. Among them, BPA is an endocrine disruptor with estrogen activity, and trace or even trace con...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F222/14C08F226/06C08F220/06C08J9/26B01J20/26B01J20/30G01N30/06G01N30/08
Inventor 陈吉平孙晓丽王金成金静王雪丽高媛
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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