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Preparation method of chitosan-cellulose anti-adhesion material for removing and inhibiting bacteria

A cellulose and chitosan technology, applied in medical science, surgery, etc., can solve problems such as local pain, infection, and reduced medical efficiency, and achieve the effect of alleviating the pain of patients, cheap and easily available raw materials, and improving the therapeutic effect.

Active Publication Date: 2015-01-07
浙江康洁丝新材料科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The incidence of surgical adhesions in surgical operations is as high as 60%-90%. Mild cases cause infection or local pain, severe cases cause serious sequelae and even affect daily life, and surgical adhesions can also lead to a reduction in medical efficiency and a reduction in medical expenses. raised
There are many measures to avoid adhesion in the prior art, such as the use of anti-inflammatory drugs, anticoagulant drugs and fibrin disintegrants, etc., but with little effect
[0003] Cellulose is the most abundant natural organic renewable resource on the earth. The global annual output exceeds 100 billion tons, but unfortunately a lot of cellulose has not been rationally utilized. The typical waste of resources is the burning of straw, which not only causes waste of resources , and seriously pollute the environment

Method used

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  • Preparation method of chitosan-cellulose anti-adhesion material for removing and inhibiting bacteria

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] S1. Mix and dissolve 10g of deionized water, 1g of ammonium sulfate, and 0.2g of magnesium sulfate in absolute ethanol, then add 4g of cotton fiber, adjust the pH value to 4, autoclave at 120°C, and then add 3g of lactic acid bacteria and stirred evenly, then let stand to cool to room temperature, suction filtered and washed with absolute ethanol and deionized water accordingly, dried and ground to obtain the intermediate product;

[0019] S2, soaking chitosan at room temperature in a hydrochloric acid solution with a mass concentration of 2% for 60 minutes, filtering, and washing with absolute ethanol and deionized water until the filtrate is neutral, drying and grinding;

[0020] S3, mix the chitosan obtained in step S2 and the intermediate product obtained in step S1 into deionized water, add NaOH solution dropwise to adjust the pH value to 7.5, boil and keep boiling for 60min, filter and clean with absolute ethanol and deionized water, The product was freeze-dried. ...

Embodiment 2

[0022] S0, microcrystalline cellulose is placed in the sodium hydroxide solution that mass concentration is 3%, and bath ratio is 1:60, heats and boils 60min, adopts plate and frame filter press to press filter and then cotton fiber is placed in mass concentration and is 20 % sodium hydroxide solution, bath ratio 1:60, stand at 40°C for 60min, take out, wash and dry to obtain alkaline microcrystalline cellulose;

[0023] S1. Mix and dissolve 15 g of deionized water, 1 g of ammonium sulfate, and 0.1 g of magnesium sulfate in acetone, then add 3 g of alkaline microcrystalline cellulose treated in step S0, adjust the pH to 6, and set the temperature at 120° C. Autoclave, then add 5g of bifidobacteria therein and stir evenly, then stand to cool to room temperature, suction filter and wash with absolute ethanol and deionized water accordingly, dry and grind to obtain the intermediate product;

[0024] S2, soak chitosan at room temperature in a hydrochloric acid solution with a mass...

Embodiment 3

[0027] S0. After the straw is pulverized, it is placed in a sodium hydroxide solution with a mass concentration of 5%, the bath ratio is 1:40, heated and boiled for 80 minutes, and the cotton fiber is placed in a mass concentration of 30% after being filtered by a plate and frame filter press. In the sodium hydroxide solution, the bath ratio is 1:40, let stand at 30°C for 60 minutes, take out, wash and dry to obtain alkaline straw cellulose;

[0028] S1. Mix and dissolve 20 g of deionized water, 1.5 g of ammonium sulfate, and 0.15 g of magnesium sulfate in methanol, then add 3 g of alkaline straw cellulose treated in step S0, adjust the pH to 5, and set the temperature at 120° C. Autoclave, then add 3g of yeast to it and stir evenly, then let it stand to cool to room temperature, suction filter and wash with absolute ethanol and deionized water accordingly, dry and grind to obtain the intermediate product;

[0029] S2, soaking chitosan at normal temperature in a hydrochloric a...

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Abstract

The invention discloses a preparation method of a chitosan-cellulose anti-adhesion material for removing and inhibiting bacteria. The preparation method comprises the following steps of: S1, mixing and dissolving deionized water, ammonium sulfate and magnesium sulfate in a reaction medium, then, adding cellulose, adjusting the pH value, sterilizing, adding probiotics therein, cooling after uniformly mixing, carrying out suction filtration, washing, drying, and grinding to obtain an intermediate product; S2, immersing chitosan in hydrochloric acid solution, filtering, washing till filtrate is neutral, drying, and grinding; and S3, mixing chitosan processed through the step S2 with the intermediate product obtained in the step S1 in the reaction medium, adjusting the pH value, boiling, filtering, cleaning, and freeze-drying to obtain the product. According to the invention, natural cellulose is used as a modified object, and raw materials are cheap and easy to obtain; the preparation method has the advantages of being reproducible, degradable, safe, environment-friendly and free from secondary pollution; the process is simple and easy to realize; the chitosan-cellulose anti-adhesion material is applied on a wound after operation suture; the anti-adhesion effect is good; furthermore, the effects of removing and inhibiting bacteria can be realized; the treatment effect is increased; and pain of patients is reduced.

Description

technical field [0001] The invention relates to the application of cellulose, in particular to a preparation method of a chitosan-cellulose anti-adhesion material which eliminates bacteria and inhibits bacteria, and belongs to the field of polymer functional materials. Background technique [0002] The incidence of surgical adhesions in surgical operations is as high as 60%-90%. Mild cases cause infection or local pain, severe cases cause serious sequelae and even affect daily life, and surgical adhesions can also lead to a reduction in medical efficiency and a reduction in medical expenses. raised. There are various measures for avoiding adhesion in the prior art, such as using anti-inflammatory drugs, anticoagulant drugs and fibrin disintegrants, etc., but with little effect. [0003] Cellulose is the most abundant natural organic renewable resource on the earth. The global annual output exceeds 100 billion tons, but unfortunately a lot of cellulose has not been rationall...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/04A61L31/16
Inventor 赵兰
Owner 浙江康洁丝新材料科技有限公司
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