Preparation method of cold heat clearing granules

A technology of Ganmao Qingre granules, which is applied in the field of preparation of Ganmao Qingre Granules, can solve the problems of low recovery rate of active ingredients, easy loss of heat-sensitive ingredients, long extraction time, etc., and achieve shortened production cycle, high recovery rate, and simplified process flow Effect

Inactive Publication Date: 2015-01-14
SUZHOU TIANLING CHINESE TRADITIONAL MEDICINE SLICE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the above method, the decoction method is used to extract the active ingredients of the medicinal materials, which has the disadvantages of long extraction time, high extraction temperature, high energy consumption, easy loss of heat-sensitive ingredients, low recovery rate of active ingredients, troublesome post-processing, etc.
[0004] The prior art teaches β-cyclodextrin inclusion te

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The preparation method of Ganmao Qingre Granules includes the following steps:

[0025] Step 1. Mix Nepeta ears, mint and perilla leaves, pulverize them into coarse powder, immerse them in 90wt.% ethanol aqueous solution for 24h at a percolation rate of 3mL / min, collect the percolate, and extract 4 times with ether. The extract Ⅰ was recovered under reduced pressure;

[0026] Step 2. Mix fenfeng, Bupleurum, Pueraria lobata root, Platycodon grandiflorum, bitter almond, Angelica dahurica, Kudi Ding and reed root, pulverize it into coarse powder, add water to decoc, and add water weight of fenfeng, Bupleurum, Pueraria lobata, Platycodon, Two times the total weight of bitter almond, angelica, kuditin and reed root, filtered, combined the filtrate, the filtrate was adsorbed by the macroporous adsorption resin HDP-100, and then eluted with 70wt.% ethanol aqueous solution. The ultrafiltration membrane is filtered and concentrated and dried to obtain extract II, the molecular weigh...

Embodiment 2

[0031] The preparation method of Ganmao Qingre Granules includes the following steps:

[0032] Step 1. Mix Nepeta ears, mint and perilla leaves, pulverize them into coarse powder, immerse them in 95wt.% ethanol aqueous solution for 24h at a percolation rate of 4mL / min, collect percolate, and extract 4 times with ether. The extract Ⅰ was recovered under reduced pressure;

[0033] Step 2. Mix fenfeng, Bupleurum, Pueraria lobata root, Platycodon grandiflorum, bitter almond, Angelica dahurica, Kudi Ding and reed root, pulverize it into coarse powder, add water to decoc, and add water weight of fenfeng, Bupleurum, Pueraria lobata, Platycodon grandiflorum, Three times the total weight of bitter almond, angelica, kuditin and reed root, filtered, combined the filtrate, the filtrate was adsorbed by the macroporous adsorption resin HDP-722, and then eluted with a 75wt.% ethanol aqueous solution. The ultrafiltration membrane is filtered and concentrated and dried to obtain extract II, the mo...

Embodiment 3

[0038] The preparation method of Ganmao Qingre Granules includes the following steps:

[0039] Step 1. Mix Nepeta ears, mint and perilla leaves, crush them into coarse powder, soak in 95wt.% ethanol aqueous solution for 24h, percolate at 5mL / min, collect percolate, extract 4 times with ether, and extract The extract Ⅰ was recovered under reduced pressure;

[0040] Step 2. Mix fenfeng, Bupleurum, Pueraria lobata root, Platycodon grandiflorum, bitter almond, Angelica dahurica, Kudi Ding and reed root, pulverize it into coarse powder, add water to decoc, and add water weight of fenfeng, Bupleurum, Pueraria lobata, Platycodon grandiflorum, Two times the total weight of bitter almonds, angelica dahurica, kuditin and reed root, filtered, combined the filtrate, the filtrate was adsorbed by the macroporous adsorption resin HDP-750, and then eluted with 80wt.% ethanol aqueous solution. After being filtered by an ultrafiltration membrane, it is concentrated and dried to obtain extract II. T...

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Abstract

The invention discloses a preparation method of cold heat clearing granules. The preparation method comprises the following steps: firstly, mixing schizonepeta spike, mint and perilla leaf, grinding and dipping the mixture through an ethanol water solution, percolating, extracting percolate through diethyl ether, decomposing and recovering extract liquor to obtain an extract I; then, mixing divaricate saposhnikovia root, radix bupleuri, root of kudzu vine, platycodon grandiflorum, semen armeniacae amarae, radix angelicae, bunge corydalis herb and rhizoma phragmitis, grinding and decocting the mixture in water, filtering, mixing filtrates, adsorbing the mixed filtrate through macro-porous adsorption resin, eluting through an ethanol water solution, filtering an eluent through an ultrafiltration membrane, condensing and drying to obtain an extract II; and then, adding beta-cyclodextrin to distilled water, wetting and heating to obtain a beta-cyclodextrin water liquid; and finally, adding the extract I and the extract II to the beta-cyclodextrin water liquid, stirring, spray-drying and granulating, mixing and granulating obtained granules with a thinner, a flavoring agent and a wetting agent to obtain the granules. The method disclosed by the invention not only simplifies a technological process and shortens a production cycle, but also improves a recovery rate of active ingredients and stability of the granules.

Description

Technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and specifically relates to a preparation method of Ganmao Qingre granules. Background technique [0002] Cold is divided into common cold and influenza. The common cold, called "cold" in Chinese medicine, is a common respiratory disease caused by a variety of viruses. Although the common cold mostly occurs in early winter, it can also occur in any season, such as spring and summer. The pathogenic viruses of colds in different seasons are not exactly the same. Influenza is an acute respiratory infectious disease caused by influenza virus. The virus is present in the respiratory tract of the patient, and it is transmitted to others through droplets when the patient coughs or sneezes. Cold is an extremely common and extremely harmful disease. A person who suffers from body aches, weakness, and high fever can be called a bad cold. [0003] The first edition of the Chi...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61K9/16A61K47/48A61P11/00A61P29/00A61P11/02A61P11/14A61P11/04
CPCA61K36/538A61K9/1652A61K36/232A61K36/233A61K36/238A61K36/34A61K36/488A61K36/534A61K36/535A61K36/66A61K36/736A61K36/899A61K2236/331A61K2236/333A61K2236/39A61K2300/00
Inventor 李建华
Owner SUZHOU TIANLING CHINESE TRADITIONAL MEDICINE SLICE
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