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Oil-in-water type compound colistin nanoemulsion

An oil-in-water type, colistin technology, applied in the field of medicine, can solve the problems of reduced drug bioavailability, single effect of colistin, slow drug dissolution rate, etc., to improve antibacterial effect, simple and feasible formula and method , the effect of improving bioavailability

Active Publication Date: 2015-01-14
HENAN SOAR VETERINARY PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Tablets are convenient to take orally, but the dissolution rate of the drug is slow, coupled with the first-pass effect of the liver on the drug, resulting in a decrease in the bioavailability of the drug; although the injection can avoid the first-pass effect, it is inconvenient to use, and the operation will cause a lot of pain. The patient brings pain, such as local redness, swelling and pain
Moreover, using colistin alone has a single effect and cannot obtain a more ideal curative effect.

Method used

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  • Oil-in-water type compound colistin nanoemulsion

Examples

Experimental program
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Effect test

Embodiment 1

[0031] An oil-in-water type compound colistin nanoemulsion, which is composed of: 7.1 parts of bitter melon water extract, 25 parts of surfactant (EL-40), 5 parts of cosurfactant (ethanol), 5.4 parts of colistin parts, oil (isopropyl myristate) 11 parts, distilled water 46.5 parts.

[0032] Its preparation method is as follows:

[0033] 1) Weigh 5.4g of colistin, 25g of EL40, 5g of ethanol, 11g of isopropyl myristate, 7.1g of bitter melon water extract and 46.5g of water;

[0034] 2) Stir colistin, EL40, isopropyl myristate and ethanol at room temperature to obtain an oil phase solution;

[0035] 3) dissolving the bitter melon aqueous extract in water to obtain an aqueous phase solution;

[0036] 4) Add the water phase solution into the oil phase solution, and stir evenly to obtain the nanoemulsion.

Embodiment 2

[0038] An oil-in-water type compound colistin nanoemulsion, the weight composition of which is: 2.3 parts of bitter melon water extract, 30 parts of surfactant (EL-40), 4 parts of cosurfactant (1,2 propylene glycol), viscose 10.7 parts of mycocin, 7 parts of oil (ethyl butyrate), 46 parts of water.

[0039] Its preparation method is with embodiment 1.

Embodiment 3

[0041]An oil-in-water type compound colistin nanoemulsion, the weight composition is: 7.3 parts of bitter melon water extract, 20 parts of surfactant (RH-40), 8 parts of cosurfactant (glycerol), colistin 8.5 parts, 9 parts of oil (castor oil), 47.2 parts of water.

[0042] Its preparation method is with embodiment 1.

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Abstract

The invention relates to an oil-in-water type compound colistin nanoemulsion and belongs to the technical field of medicines. The oil-in-water type compound colistin nanoemulsion comprises the following components in parts by weight: 1-18 parts of bitter gourd aqueous extract, 15-40 parts of surfactant, 0-20 parts of cosurfactant, 1-20 parts of colistin, 1-20 parts of oil and 20-70 parts of water. The compound colistin nanoemulsion is narrow in particle size distribution, transparent in system, good in stability, relatively low in surface tension, good in liquidity and easy to take, and the nanoemulsion preparation is used for improving dissolvability and permeability of colistin, so that bioavailability of the medicine is improved; a bitter gourd aqueous extract and the colistin are combined, so that the antibacterial activities of the bitter gourd aqueous extract and the colistin are mutually promoted and enhanced, and the antibacterial effect is more stable.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an oil-in-water nanoemulsion—a compound antibacterial nanoemulsion with bitter melon water extract and colistin as active ingredients. Background technique [0002] Colistin, also known as colistin, colistin, polymyxin E (Polymyxin E), anti-enemy, etc., is an alkaline cyclic polypeptide (polypeptide) obtained from the culture medium of polymyxin bacteria. system) antibiotics, a mixture of polymyxins E1 and E2. It is white crystal or crystalline powder, slightly soluble in water, not easy to deliquescence. Its sulfate, colistin sulfate, is very stable and is a white powder, easily soluble in water, slightly soluble in methanol and ethanol, and insoluble in acetone and ether. It is more stable in the pH range of 3-7.5. Heat-resistant, difficult to absorb in the digestive tract, rapid excretion, low toxicity, no side effects, and not easy to produce drug-resistant st...

Claims

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Application Information

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IPC IPC(8): A61K38/12A61K9/107A61P31/04
Inventor 孙江宏阮心洁岳旭龙
Owner HENAN SOAR VETERINARY PHARMA
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