Pharmaceutical composition sustained-release implant containing caspofungin acetate and preparation thereof
A technology of caspofungin acetate and slow-release implants, which can be applied to medical preparations containing active ingredients, drug delivery, and pharmaceutical formulations, and can solve the problems of frequent and inconvenient administration
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Embodiment 1
[0020] Weigh 120 g of caspofungin acetate and 30 g of amphotericin B, dissolve and disperse them in distilled water to obtain an inner water phase; weigh 300 g of PLGA and dissolve them in dichloromethane to obtain an oil phase. Preparation concentration is 200ml of polyvinyl alcohol solution of 0.5%. First move the main drug solution into the dichloromethane solution that is dissolved with PLGA, put it on the emulsification disperser at room temperature and emulsify it for 30 seconds with a rotating speed of 30000rpm, then transfer the obtained W / O emulsion to 200ml concentration of 0.5%. In the vinyl alcohol solution, put it on an emulsifying disperser at a speed of 5000rpm, and mix it evenly for 1 minute to obtain a W / O / W type double emulsion. , centrifuged, collected the microspheres obtained, washed several times with distilled water, then collected by centrifugation, added 10g of mannitol, and freeze-dried to obtain drug-containing sustained-release microspheres, the enc...
Embodiment 2
[0025] Weigh 80 g of caspofungin acetate and 20 g of fluconazole, dissolve and disperse them in distilled water to obtain an inner water phase; weigh 350 g of PLA and dissolve them in dichloromethane to obtain an oil phase. Preparation concentration is 200ml of polyvinyl alcohol solution of 0.5%. First move the main drug solution into the dichloromethane solution that is dissolved with PLA, put it on the emulsification disperser at room temperature and emulsify it with a rotating speed of 30000rpm for 30 seconds, then transfer the resulting W / O emulsion to 200ml concentration of 0.5% poly In the vinyl alcohol solution, put it on an emulsifying disperser at a speed of 5000rpm, and mix it evenly for 1 minute to obtain a W / O / W type double emulsion. , centrifuge, collect the gained microspheres, wash with distilled water several times, then centrifuge again, add 20g sorbitol, freeze-dry, obtain the drug-containing sustained-release microspheres, its encapsulation efficiency is 91....
Embodiment 3
[0030]Weigh 35g of caspofungin acetate, 7.5g of amphotericin B, and 7.5g of itraconazole, dissolve and disperse them in distilled water to obtain an inner water phase; weigh 400g of PGA and dissolve them in dichloromethane to obtain an oil phase. Preparation concentration is 200ml of polyvinyl alcohol solution of 0.5%. First move the main drug solution into the dichloromethane solution that is dissolved with PGA, put it on the emulsification disperser at room temperature and emulsify it for 30 seconds with a rotating speed of 30000rpm, then transfer the obtained W / O type emulsion to 200ml concentration of 0.5% poly In the vinyl alcohol solution, put it on an emulsifying disperser at a speed of 5000rpm, and homogenize it for 1 minute to obtain a W / O / W type double emulsion. phase, centrifuge, collect the obtained microspheres, wash with distilled water for several times, then collect by centrifugation, add 30g mannitol, and freeze-dry to obtain drug-containing sustained-release ...
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