Preparation method of wound dressing with optimal water vapor permeability

A water vapor transmission rate and wound surface technology, which is applied in medical science, bandages, absorbent pads, etc., can solve the problems that there is no uniform and general standard for the water vapor transmission rate range, and it has not been followed to achieve a good water vapor transmission rate , It is not easy to accumulate exudate, and the effect of increasing the shrinkage rate and healing rate

Inactive Publication Date: 2015-04-08
THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are certain limitations in this report. It is not supported by relevant animal experiments, pathological experiments, and molecular biology experiments. It is only determined by the water evaporation of granulation tissue; The extent is not exactly the same, so this report should also support the applicable wound types of dressings in this water vapor transmission rate range
[0004] In fact, the water vapor transmission rates of various dressings or artificial skin products currently commercialized do not follow the water vapor transmission rates recommended in literature reports. The water vapor transmission rates of these products range from 90g / m 2 / 24h(Dermiflex,Johnson&Johnson) to 3350g / m 2 / 24h (Beschitin, Unitika) varies
[0005] Therefore, there is no uniform and general standard for the water vapor transmission rate range of dressings used for different types of wounds, regardless of literature reports or product production processes, which have different degrees of impact on the design and production of dressings and clinical therapeutic effects. influences

Method used

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  • Preparation method of wound dressing with optimal water vapor permeability
  • Preparation method of wound dressing with optimal water vapor permeability
  • Preparation method of wound dressing with optimal water vapor permeability

Examples

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preparation example Construction

[0025] The invention provides a method for preparing a wound dressing with optimum water vapor transmission rate, comprising the steps of:

[0026] a. Dissolve polyurethane pellets TPU in N,N-dimethylformamide DMF to make the concentration 65-90g / L;

[0027] b. After the dissolution is complete, gradually add sodium citrate powder to the solution system to make the concentration 1050g / L-650g / L; slowly pour the coating solution into the mold;

[0028] c. Place the mold at 90-110°C for 60-240 minutes;

[0029] d. Put the formed film and mold into deionized water, soak for 72 hours, and replace the deionized water every 12 to 24 hours;

[0030] e. Put the prepared porous film in an oven at 40-50°C and dry it to obtain a water vapor transmission rate in the range of 1500-3500g / m 2 / 24h wound dressing.

[0031] Preferably, the concentration of TPU dissolved in DMF in step a is 90g / L.

[0032] Preferably, the final concentration of sodium citrate powder dissolved in step b is 6...

Embodiment 1

[0038] The polyurethane dressing preparation of the water vapor transmission rate of embodiment 1 different gradients

[0039] Polyurethane pellets / sodium citrate / dimethylformamide are formulated into solutions in the following proportions: 13g / 40g / 100ml, 9g / 65g / 100ml, 6.5g / 105g / 100ml; stir for 30 minutes to form a suspension. The suspension is poured on a polytetrafluoroethylene plate, cast evenly, and the thickness of the liquid film is controlled to be 1mm by the amount of the suspension poured. Put it in a 100°C oven to evaporate the solvent to form a film. When most of the solvent evaporated, the film was soaked in deionized water for about 72 hours to completely dissolve the sodium citrate. Take out the film and put it in a 40°C oven to dry.

Embodiment 2

[0040] Embodiment 2 water vapor transmission rate test

[0041] The water vapor transmission rate of 3 kinds of wound dressings obtained in Example 1 is tested, and the test process is as follows:

[0042] Use the test cup (inner diameter 34mm), fix the dressing to be tested with a diameter of about 35mm on the mouth of the cup, and the top and bottom of the dressing are lined with rubber sealing rings. Fill the cup with 10ml of double distilled water, fix the dressing on it, and rotate to seal. Place the water cup in a constant temperature box with a temperature of 37°C and a humidity of 39%. Weigh once every 2h thereafter, and the water vapor transmission rate is automatically calculated and recorded by a water vapor transmission rate tester (W3 / 030, Labthink). The measured results are shown in Table 1.

[0043] Table 1 Water Vapor Transmission Rate

[0044]

[0045]

[0046] Note: Four layers of gauze and rubber gloves, two clinically common medical products, were...

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Abstract

The invention belongs to the technical field of biological materials of tissue engineering, particularly relates to a preparation method of a wound dressing with optimal water vapor permeability and provides a polyurethane wound dressing for skin wounds. According to the technical scheme, the preparation method of the wound dressing with the optimal water vapor permeability comprises the following steps: completely dissolving polyurethane particles in N,N-dimethylformamide, and adding sodium citrate powder into the solution; pouring the solution into a mold, standing at 100 DEG C for 60-240 minutes, immersing the mold in deionized water, and drying, so as to obtain the wound dressing with the water vapor permeability of 1500-3500g / m<2> / 24h. The wound dressing prepared by virtue of the preparation method has good water vapor permeability and is beneficial to the wound recovery.

Description

technical field [0001] The invention belongs to the technical field of tissue engineering biomaterials, and in particular relates to a preparation method of a wound dressing with an optimal water vapor transmission rate. Background technique [0002] The skin is the largest organ of the human body and an important natural barrier to protect the body. For severe skin defects such as patients with extensive burns, a large amount of water, electrolytes and nutrients are lost from the wound, which may lead to a series of problems such as water and electrolyte imbalance and shock, and the formation of skin wounds also provides conditions for the reproduction of bacteria , resulting in serious infection. Large-area skin defects often require autologous skin to cover the wound. However, due to the limited source of autologous skin, it is particularly important to use wound dressings to protect the wound simply and quickly, thereby saving the lives of more patients. [0003] On th...

Claims

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Application Information

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IPC IPC(8): A61L15/26A61L15/42
Inventor 徐瑞吴军罗高兴夏和生贺伟峰王玉振赵健李志超
Owner THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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