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Preparation method and product of superparamagnetism nano particles

A magnetic nanoparticle and superparamagnetic technology, applied in the field of nanomaterials, can solve the problems of low adsorption capacity and low positive charge of natural proteins, and achieve improved stability and biocompatibility, short synthesis cycle, and adsorption capacity. strong effect

Active Publication Date: 2015-04-22
广纳达康(广州)生物科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] For the above defects or improvement needs of the prior art, the invention provides a preparation method of superparamagnetic nanoparticles and products thereof, the purpose of which is to increase an appropriate amount of aluminum ions in the process of preparing ferric oxide by co-precipitation method, thereby Generate superparamagnetic iron oxide nanoparticles with a large number of positive charges, thereby solving the technical problem of low positive charge on the surface of superparamagnetic iron oxide nanoparticles prepared by co-precipitation method, and low adsorption capacity for natural proteins with negative charges

Method used

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  • Preparation method and product of superparamagnetism nano particles
  • Preparation method and product of superparamagnetism nano particles
  • Preparation method and product of superparamagnetism nano particles

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[0026] The preparation method of superparamagnetic nanoparticles provided by the invention comprises the following steps:

[0027] (1) Under the condition of isolating oxygen, the Fe 3+ 、Al 3+ , Fe 2+ Evenly dispersed in water to form a precursor solution, so that Fe 3+ The concentration is between 0.05mol / L and 0.5mol / L, Fe 3+ and Fe 2+ The molar ratio of Fe is 2:1, Fe 3+ and Al 3+ The molar ratio is between 15:1 and 4:1.

[0028] (2) Under the condition of cutting off oxygen, keep stirring the precursor solution obtained in step (1), maintain the temperature at 30°C to 60°C, and slowly add lye dropwise to adjust the pH value of the solution to be greater than or equal to 9 to form a suspension ; Preferably, the stirring speed is 800rpm to 2000rpm, and the dropping rate of lye is 0.5mL / min to 4mL / min. The lye is sodium carbonate solution, ammonia solution or sodium hydroxide solution with pH ≥ 9.5. In order to make the product more evenly dispersed, citrate ions can ...

Embodiment 1

[0034] A preparation method of superparamagnetic nanoparticles, comprising the following steps:

[0035] (1) Take 250mL of ultrapure water, pass nitrogen gas for 10 minutes, then add 7.78g of FeCl in sequence 3 ·6H 2 O, 1.60g Al(NO 3 ) 3 9H 2 O and 2.86 g FeCl 2 4H 2 O, the Fe 3+ 、Al 3+ , Fe 2+ Evenly dispersed in water to form a precursor solution, so that Fe 3+ The concentration is 0.115mol / L, Fe 3+ and Fe 2+ The molar ratio of Fe is 2:1, Fe 3+ and Al 3+ The molar ratio is 6.4:1.

[0036] (2) Under the protection of nitrogen, keep stirring the precursor solution obtained in step (1), maintain the temperature at 40°C, and add 100mL of lye dropwise, the lye is 2mol / L ammonia solution, and the pH of the final solution is ≥9 , forming a suspension; the stirring speed is 1500rpm, and the dropping rate of lye is 2mL / min.

[0037](3) Under the protection of nitrogen, keep stirring the suspension obtained in step (2), and raise the temperature to 80°C, react for 0.5 h...

Embodiment 2

[0040] (1) Take 250mL of ultrapure water, pass nitrogen gas for 10 minutes, then add 20.27g of FeCl in sequence 3 ·6H 2 O, 7.03g Al(NO 3 ) 3 9H 2 O and 7.46 g FeCl 2 4H 2 O, the Fe 3+ 、Al 3+ , Fe 2+ Evenly dispersed in water to form a precursor solution, so that Fe 3+ The concentration is 0.3mol / L, Fe 3+ and Fe 2+ The molar ratio of Fe is 2:1, Fe 3+ and Al 3+ The molar ratio is 4:1.

[0041] (2) Under the protection of nitrogen, keep stirring the precursor solution obtained in step (1), maintain the temperature at 30°C, and add dropwise 200 mL of lye, which is 1 mol / L NaOH solution, and the final pH value of the solution is ≥9 , forming a suspension; the stirring speed is 2000rpm, and the dropping rate of the lye is 4mL / min. While adding the lye dropwise, use a 400kHz, 50W ultrasonic generator to supplement the entire reaction vessel with ultrasonic vibration.

[0042] (3) Under the protection of nitrogen, keep stirring the suspension obtained in step (2), and r...

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Abstract

The invention discloses a preparation method of water-soluble superparamagnetism nano particles with high adsorption capacity for proteins. The method is characterized in that aluminum ions of an appropriate amount are added in the process for preparing ferriferrous oxide in a co-precipitation method, Fe<3+>, Al<3+> and Fe<2+> are co-precipitated under the effect of alkaline solution, and the superparamagnetism ferric oxide nano particles with a great amount of positive charges are generated. Compared with the ferriferous oxide nano particles prepared in a traditional co-precipitation method, the surface of the ferric oxide nano particles prepared in the method is provided with more positive charges, so that the stability in an aqueous solution is better, and the adsorption capacity for the natural proteins with negative charges is higher.

Description

technical field [0001] The invention belongs to the field of nanomaterials, and more specifically relates to a preparation method of superparamagnetic nanoparticles and products thereof. Background technique [0002] Magnetic nanoparticles are a kind of magnetic material at the nanometer level, which has quantum size effect, surface effect, small size effect and macroscopic quantum tunneling effect. Magnetic nanoparticles have good magnetic guidance, biocompatibility and biodegradability, etc., and can be combined with a variety of biological functional molecules, such as enzymes, DNA, proteins, etc., in DNA separation and purification, magnetic targeted drug delivery, medical detection , diagnosis, gene therapy, cell separation, immune analysis, immobilized enzymes and proteins, etc., has a wide range of application prospects. [0003] The preparation of magnetic nanoparticles generally includes radiation polymerization, thermal curing and co-precipitation methods, among w...

Claims

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Application Information

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IPC IPC(8): B01J20/06B01J20/28B01J20/30C07K1/22H01F1/04
CPCB01J20/06B01J20/28009B01J20/3085B01J2220/4806C07K1/22H01F1/04
Inventor 杨海杨勇黄燕婷周坤向雯琦金伟杨祥良
Owner 广纳达康(广州)生物科技有限公司
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