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Carbon fiber electric atomizing ionization device and method for realizing electric atomizing ionization by using device

An electrospray ionization and carbon fiber technology, applied in the field of mass spectrometry analysis, can solve problems such as unseen carbon fibers, and achieve the effects of suppressing the influence of the measurement, simplifying the sampling operation, and having strong universality.

Active Publication Date: 2015-05-06
SHANGHAI INST OF ORGANIC CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These surprising results have enriched the understanding of materials that can be used as electrospray substrates, but so far there have been no reports on the use of carbon fibers as electrospray substrate materials

Method used

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  • Carbon fiber electric atomizing ionization device and method for realizing electric atomizing ionization by using device
  • Carbon fiber electric atomizing ionization device and method for realizing electric atomizing ionization by using device
  • Carbon fiber electric atomizing ionization device and method for realizing electric atomizing ionization by using device

Examples

Experimental program
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Effect test

Embodiment 1

[0055] Adopt carbon fiber electrospray ionization device of the present invention and mass spectrometer (mass analyzer is a triple quadrupole) to nitrogen-containing compound 1,4-diazabicyclo[2.2.2]octane (DABCO): Perform mass spectrometry:

[0056] Use a mixed solvent of methanol and water with a volume ratio of 1:1 to configure DABCO into a sample solution to be tested at about 0.1 mg / mL; make the sampling and electrospray end 11 directly dip into the sample solution, and at the same time inject the solvent acetonitrile through the injection pump Lead the solvent / sample introduction channel 4 to the sampling and electrospray end 11 at a flow rate of 2 to 5 μL / min; turn on the power supply, and gradually increase the voltage to the ionization voltage of the electrospray, so that the sampling and electrospray end 11 performs electrospray desorption. Solvent, forming sample ions for mass spectrometry analysis.

[0057] Depend on image 3 Shown mass spectrogram is visible: in...

Embodiment 2

[0059] Adopt carbon fiber electrospray ionization device of the present invention and mass spectrometer (mass analyzer is a triple quadrupole) to slightly soluble small polar compound anisidine: Perform mass spectrometry:

[0060] Use CH 2 Cl 2 Configure anisidine to be about 0.1 mg / mL of the sample solution to be tested; use a pipette to pipette 2 μL and drop it to the sampling and electrospray port 11; Perform electrospray desolvation with the electrospray end 11 to form sample ions for mass spectrometry analysis.

[0061] Depend on Figure 4 The shown mass spectrogram can be seen: in the spectrogram, except the ion peak (m / z) 124 related to the compound, there is no interference of other impurity ion peaks, which shows that the device and method of the present invention are used for the non-conductivity of poor conductivity. Test compounds in polar solvents also have good ionization efficiencies.

Embodiment 3

[0063] Adopt carbon fiber electrospray ionization device of the present invention and mass spectrometer (mass analyzer is a triple quadrupole) to steroidal compound dehydroepiandrosterone: Perform mass spectrometry:

[0064] Use ethanol to configure dehydroepiandrosterone into a sample solution to be tested at about 0.1 mg / mL; use a pipette to pipette 2 μL and drop it to the sampling and electrospray port 11; turn on the power to gradually increase the voltage to the electrospray The ionization voltage enables the sampling and electrospray end 11 to perform electrospray desolvation to form sample ions for mass spectrometry analysis.

[0065] Depend on Figure 5 The mass spectrogram shown can be seen: in the spectrogram, except for ion peaks (m / z) 271 and 289 (respectively proton peak and proton dehydration peak of the target compound) related to the compound, there is no interference from other impurity ion peaks , indicating that the device and method of the present invent...

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Abstract

The invention discloses a carbon fiber electric atomizing ionization device and a method for realizing electric atomizing ionization by using the device. The carbon fiber electric atomizing ionization device comprises a carbon fiber bundle used as an electric atomizing base; a fixed pipe sleeves the carbon fiber bundle; a carbon fiber bundle end penetrating out from the front end of the fixed pipe is a sampling and electric atomizing end; a carbon fiber bundle end penetrating out from the rear end of the fixed pipe is fixedly provided with a conductive metal foil; the conductive metal foil is connected with a positive electrode of a high-voltage power supply. The method for realizing the electric atomizing ionization by using the device comprises the following steps: introducing a sample into the sampling and electric atomizing end; switching on a power supply to raise voltage to ionization voltage of electric atomization so that the electric atomization is carried out by the sampling and electric atomizing end. The carbon fiber electric atomizing ionization device has the advantages that sampling, cleaning and reutilization are very convenient, also has the advantages of simple structure, low cost, high safety, strong universality, wide application range, easiness for realization and the like, and has an obvious popularization and application value.

Description

technical field [0001] The invention relates to a carbon fiber electrospray ionization device and a method for using the device to realize electrospray ionization, belonging to the technical field of mass spectrometry. Background technique [0002] Mass spectrometry (MS) is a powerful tool for the analysis of complex mixtures, providing information about the molecular weight and chemical structure of the analyte. Common ionization methods include the use of electrospray ionization (ESI) or atmospheric pressure chemical ionization (APCI), while matrix-assisted laser desorption ionization (MALDI) is commonly used for solids. Mixtures are typically separated using chromatography prior to MS determination to minimize inhibitory effects on analyte ionization and to pre-concentrate the analytes. [0003] Electrospray ionization (ESI), since its introduction in the 1970s, has become the most widely used ionization method in the field of mass spectrometry because of its soft ioniza...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): H01J49/16H01J49/04H01J49/26
CPCH01J49/165
Inventor 郭寅龙吴梦茜王昊阳张芳祁婉舒范若静
Owner SHANGHAI INST OF ORGANIC CHEM CHINESE ACAD OF SCI
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