Molybdenum compound of 15-crown-5 and MoO2Cl2(H2O)2, preparation method and application thereof

A molybdenum compound, mocl2o2 technology, applied in the field of biomedicine, can solve problems such as instability of ammonium tetrathiomolybdate, and achieve the effects of excellent inhibition, high yield, good water solubility and fat solubility
CN104628699AInactive Publication Date: 2015-05-20CAPITAL NORMAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN Β· China
Current Assignee / Owner
CAPITAL NORMAL UNIVERSITY
Publication Date
2015-05-20
Estimated Expiration
Not applicable Β· inactive patent

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Abstract

The invention relates to a molybdenum compound [MoO2Cl2(H2O)2][15C5] of 15-crown-5 and molybdenum, preparation method and application thereof. The molybdenum compound provided by the invention can prevent and inhibit the formation and growth of cancers and tumors, and can be used for preparation of drugs preventing and treating cancer and tumor diseases. Synthesis of the compound drug provided by the invention has the characteristics of easily available raw materials and low cost, the product precipitates out in the form of crystals, has high purity and yield, can stably exist under natural state, has good water solubility and lipid solubility, and presents excellent inhibition effect on A-549 (lung cancer), Bel-7402 (liver cancer), and HCT (colonic adenocarcinoma).
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Description

technical field

[0001] The present invention relates to molybdenum compounds of 15 crown 5 and molybdenum [MoCl 2 o 2 (H 2 O) 2 ][15C5] and its preparation method and application, the present invention can prevent and inhibit the formation and growth of cancer and tumors, can be used to prepare drugs for the prevention and treatment of cancer and tumor diseases, and belongs to the field of biomedicine. Background technique

[0002] The element molybdenum is an important trace element of life. Regional studies have shown that: in high-incidence areas such as esophageal cancer, digestive tract cancer, gastric cancer, liver cancer, rectal cancer, lung cancer, and breast cancer, such as Lin County in Henan, residents' serum, urine samples and The content of molybdenum in the hair is significantly lower than that in the low hair area. Animal experiments showed that after molybdenum-deficient animals and normal animals received a certain dose of nitroso compounds at the same t...

Claims

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