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40 results about "15-Crown-5" patented technology

15-Crown-5 is a crown ether with the formula (C₂H₄O)₅. It is a cyclic pentamer of ethylene oxide that forms complex with various cations, including sodium (Na⁺) and potassium (K⁺), however, it is complementary to Na⁺ and thus has a higher selectivity for Na⁺ ions.

Preparation method of iridium complex-containing phosphorescence material and its application in cobalt ion detection

Belonging to the technical field of photoelectric phosphorescence materials, the invention discloses a preparation method of an iridium complex-containing phosphorescence material and its application in cobalt ion detection. With a general structural formula as shown in formula I, the iridium complex-containing phosphorescence material of the invention can be used for Co<2+> detection and comprises a main ligand and an auxiliary ligand, wherein, the main ligand is a derivative of 3, 4-disubstituted cinnoline, and the auxiliary ligand is a derivative of 15 crown-5 ether dipyridine. By means of the influence of Co<2+> on photo-physical and sensing properties of the iridium complex, the phosphorescence chemical sensor can observe the change of its phosphorescence emission spectrum so as to reach the Co<2+> detection purpose. The phosphorescence chemical sensor of the invention has the advantages of rapid phosphorescence response speed, easy differentiation from a fluorescence background, large range, high identification sensitivity to Co<2+>, good stability, and applicability for Co<2+> detection in various environments, and small interference from other positive ions, etc. Formula I is shown as the following.
Owner:ANHUI UNIVERSITY OF TECHNOLOGY

Synthesis of beta-L-2'-deoxy nucleosides

InactiveUS20050059632A1High percent product yieldPercent product yieldEsterified saccharide compoundsBiocideDisplacement reactionsAlternative methods
An improved process for the preparation of 2′-modified nucleosides and 2′-deoxy-nucleosides, such as, β-L-2′-deoxy-thymidine (LdT), is provided. In particular, the improved process is directed to the synthesis of a 2′-deoxynucleoside that may utilize different starting materials but that proceeds via a chloro-sugar intermediate or via a 2,2′-anhydro-1-furanosyl-nucleobase intermediate. Where an 2,2′-anhydro-1-furanosyl base intermediate is utilized, a reducing agent, such as Red-Al, and a sequestering agent, such as 15-crown-5 ether, that cause an intramolecular displacement reaction and formation of the desired nucleoside product in good yields are employed. An alternative process of the present invention utilizes a 2,2′-anhydro-1-furanosyl base intermediate without a sequestering agent to afford 2′-deoxynucleosides in good yields. The compounds made according to the present invention may be used as intermediates in the preparation of other nucleoside analogues, or may be used directly as antiviral and / or antineoplastic agents.
Owner:NOVARTIS AG

Application of benzo-azacrown ether compounds to separation of lithium isotopes

The invention discloses application of benzo-azacrown ether compounds to separation of lithium isotopes. The benzo-azacrown ether compounds are selected from monoaza15-crown-5, bisaza15-crown-5, triaza15-crown-5 and bisaza18-crown-6. The benzo-azacrown ether compounds serving as extracting agents are dissolved in organic solvents to prepare organic phases, a lithium trifluoroacetate aqueous solution serves as an aqueous phase, and the lithium isotopes are separated at the room temperature by liquid-liquid extraction. The benzo-azacrown ether compounds are easy to dissolve in the organic solvents, efficient separation of the lithium isotopes can be realized by means of liquid-liquid extraction, and considerable separation factors, simplicity and convenience in operation, quickness in isotope exchange and technical simplicity are realized.
Owner:SHANGHAI ADVANCED RES INST CHINESE ACADEMY OF SCI

Adsorbent for separating palladium from alkali metals and alkaline-earth metals and its preparation method and use

The invention discloses an adsorbent for separating palladium from alkali metals and alkaline-earth metals. 4-[3-(3-benzo-15-crown-5)methyl-4-hydroxy-phenyl]methylethyl-phenolic resin is supported by carriers to form the adsorbent. The 4-[3-(3-benzo-15-crown-5)methyl-4-hydroxy-phenyl]methylethyl-phenolic resin has a structural general formula (I), wherein in the structural general formula (I), n is an integer of 7-15. The carriers are porous silica gel or large-hole SiO2 coated by a polymer. The invention also discloses a preparation method and a use of the adsorbent for separating palladium from alkali metals and alkaline-earth metals. The preparation method has simple processes. The adsorbent obtained by the preparation method has good selectivity in palladium separation. The palladium separation process adopting the adsorbent is simple. The adsorbent has high separation efficiency and can be industrially produced easily.
Owner:ZHEJIANG UNIV

Synthesis method of fluorescent reagent for identifying specificity and sensitively detecting human albumin and application

The invention belongs to the field of biological macromolecular probes, and particularly relates to a fluorescent reagent and a method for measuring human albumin and efficiently and quickly identifying the human albumin and bovine serum albumin. A schiff base organic compound with a typical torsion intramolecular charge transfer feature is designed and synthesized on the basis of a triphenylamine and 15-crown-5 ester structure, and is used as the fluorescent reagent; protein is added into a neutral phosphate buffer solution, the human albumin can be quickly identified from several types of common proteins according to compound fluorescent spectrum features, and a standard curve is established to quantitatively measure the contents of serum proteins in a buffered saline solution and artificial urine. The concentration of the probe reagent is 50mu M, and the 5mu M human albumin can be identified; after quantitative detection, the range of the human albumin in the buffered saline solution is 0 to 5.6mu M, and the minimum detection limit is 0.112mg / L; the range of the human albumin in the artificial urine is 0 to 1.2mu M, and the minimum detection limit is 1.95mg / L.
Owner:宜都市华阳化工有限责任公司

Crown ether cyclic quinazoline compound, preparation method therefor and application thereof in preparing tumor therapy and imaging drug

The invention relates to a crown ether cyclic quinazoline derivative and medicinal salts thereof using in tumor therapy and imaging. The crown ether cyclic quinazoline compound is characterized in that a 2-, 3-, 4- substituted aniline is disposed at one end; a 6-, 7- substituted crown ether cyclic quinazoline structure is disposed at the other end; the substituent group R1 is located on the fourth-position aniline of a quinazoline mother ring and is 2-, 3-, 4- substituted alkoxy; and the crown ether cycle is located at the 6, 7 position of the mother ring, and is a 9-crown-3, 12-crown-4 and 15-crown-5, and the structural formula is formula I. The experimental result of antitumor activity in vitro of nonradioactive isotope labeling compounds shows that the compounds are good in inhibitory effect for four kind of cancer cells namely HepG2, A549, sy5y and DU145, and have the potential as cancer treatment medicine; and the body distribution experiment of 18F or 125I labeling compounds show that the compounds are higher in ingestion and certain detention in tumors and faster in blood clearance and have potential applied to tumor imaging.
Owner:BEIJING NORMAL UNIVERSITY

Method for preparing functional polymer micro-porous membrane with reaction-solution phase inversion control method

The invention belongs to the technical field of functional polymer membrane separation, and relates to a method for preparing a crown-ether graft polymer micro-porous membrane with a reaction-solution phase inversion control method. The method includes the steps that a chloromethyl-containing polymer such as polysulfone or polyether sulfone or polyether ether ketone is dissolved into a reaction solvent, an active-amido containing crown ether compound such as 4-aminobenzene-15-crown-5 is added, and a crown ether graft polymer is prepared through a nucleophilic substitution reaction between chloromethyl and amino; the grafting ratio of the reaction is controlled; in other words, when a reaction system is in certain viscosity, the reaction is terminated to prevent gelatinizing, the reaction system at the moment serves as a membrane casting solution, and the crown-ether graft polymer micro-porous membrane is prepared with the solution phase inversion method. As a cross bond exists in the polymer system, it can be achieved that the polymer micro-porous membrane which is high in porosity ratio and breaking strength is prepared under the low solid content of the polyether, and the separation step and the purification step of the grafted polymer are omitted; as a crown ether group exists, the polymer membrane has excellent lithium isotope separation performance.
Owner:TIANJIN POLYTECHNIC UNIV

Crown ether ring-shaped quinazoline nitrogen mustard compound, and preparation method and application thereof in tumor treatment

A new crown ether ring-shaped quinazoline nitrogen mustard compound or a pharmaceutically-acceptable salt thereof is characterized in that: one end is provided with a nitrogen mustard alkylated group; the other end is provided with a 6,7-substituted crown ether ring-shaped quinazoline structure; a substituted group R is located at a site 4 of a quinazoline matrix and represents 2-nitrogen mustard group, 3-nitrogen mustard group or 4-nitrogen mustard group; a crown ether ring is located at sites 6 and 7 of the quinazoline matrix and represents 9-crown-3, 12-crown-4 or 15-crown-5; and the compound has a structure represented by a formula I. Experiments show that the compound has better antitumor activity and also has selectivity on different tumor cells. At the same time, the compound is easy to synthesize and simple in operation. Advantages of the compound show that the compound has great potential to become a drug for treatment of tumor.
Owner:BEIJING NORMAL UNIVERSITY

Preparation method of polyether macromonomer for polycarboxylate water reducer

The invention discloses a preparation method of a polyether macromonomer for a polycarboxylate water reducer. The preparation method comprises the following steps: (1) taking a part of methyl allyl alcohol to react with a catalyst one, then putting a reacted product into the remaining methallyl alcohol, and introducing ethylene oxide and propylene oxide for reaction, so that a methylallyl random oligomer is obtained; and (2) allowing the methylallyl random oligomer to react with a catalyst two and a catalyst three, and then introducing ethylene oxide and propylene oxide for reaction; wherein the catalyst one is one or more of sodium, potassium and sodium hydride; the catalyst two is one or more of 18-crown-6 and 15-crown-5; and the catalyst three is phosphonitrilic chloride trimer. Compared with the prior art, the preparation method of the polyether macromonomer for the polycarboxylate water reducer has the advantages that the effective content is high, the by-product content is low, the molecular weight distribution is narrow, the double bond retention rate is high, and the likes, wherein a molecular weight distribution coefficient is less than 1.05, and the double bond retentionrate is greater than 98.0%.
Owner:ZHEJIANG HUANGMA TECH +3

High-nickel ternary lithium battery electrolyte with cycling stability

The invention belongs to the technical field of preparation of a ternary battery electrolyte, and particularly relates to a high-nickel ternary lithium battery electrolyte with cycling stability. According to the high-nickel ternary lithium battery electrolyte, an additive of the electrolyte is a mixture of dimethylaminoanisole, 4'-aminobenzo-15-crown-5-ether and sorbeth-n hexastearate, and by means of sorbeth-n hexastearate, the phenomenon of poor electrolyte infiltration caused by blockage by degradation products, breakage of battery cathode pores due to charge and discharge and the like canbe eliminated, so that cycle performance of a battery is improved; OCH3 of dimethylaminoanisole is subjected to a reaction of a solvolyte, LiOCH3 is generated, and an efficient and stable SEI (solidelectrolyte interface) film is formed; wrapped chelate is formed by 4'-aminobenzo-15-crown-5-ether and lithium ions, solubility of lithium salt can be improved, and effective separation of anion-cation pairs and separation of lithium ions and solvent molecules are realized; under the joint action of dimethylaminoanisole, 4'-aminobenzo-15-crown-5-ether and sorbeth-n hexastearate, the cycle performance of the electrolyte is improved.
Owner:CHENDU NEW KELI CHEM SCI CO LTD

Preparation method of 15-crown 5-ether

The invention relates to a preparation method of 15-crown 5-ether, which comprises the following steps: uniformly stirring triglycol and dioxane in a reaction vessel; adding sodium hydroxide and stirring, heating to 40-60 DEG C; adding a mixed liquor of dichloroethyl ether and dioxane at the temperature lower than 60 DEG C, reacting for 20-24 hours at the temperature of 60-90 DEG C; cooling to room temperature, centrifuging to obtain a filtrate; pumping the filtrate into the reaction vessel and distilling to obtain a distillation substrate; moving the distillation substrate to a stainless steel still, performing vacuum rectification, removing primary fraction to obtain the product. The preparation method has the beneficial effect that comparing with the prior art, the preparation method has the advantages of safe operation, low cost, little three wastes and high yield, and the primary fraction in the reaction can be reutilized.
Owner:KENTE CATALYSTS INC

Preparation and application of asymmetric poly(phenyleneethynylene) oligomer with ion transmembrane transfer activity

InactiveCN105541788AHas ion transmembrane transport activityHigh yieldOrganic chemistryDiseaseStructural formula
The invention relates to preparation and application of an asymmetric poly(phenyleneethynylene) oligomer with ion transmembrane transfer activity. The asymmetric poly(phenyleneethynylene) oligomer has a structural formula shown as the formula I (please see the formula I in the description), wherein R1 is selected from one of -CH2(CH2)4CH3, -CH2(CH2)6CH3, -CH2(CH2)8CH3, -CH2(CH2)10CH3, -OCH2CH2OCH2CH2O(CH2)5CH3 and -OCH2CH2OCH2CH2O(CH2)7CH3, R2 represents a cation recognition group or an anion recognition group, the cation recognition group is selected from one of benzo-15-crown-5, benzo-18-crown-6, hybridized nitrogen-15-crown-5, hybridized nitrogen-18-crown-6, dibenzo-15-crown-5 and dibenzo-18-crown-6, and the anion recognition group is selected from one of 2,6-pyridine diamide and isophthalic diamide. According to the asymmetric poly(phenyleneethynylene) oligomer, a single-molecule artificial ion channel is formed in a bi-layer membrane, ion transmembrane transfer is effectively achieved, a new method is sought for treating diseases related to function disorders of the ion channel, and the important application value in the field of antibacterial and anti-cancer biological medicine for treating diseases is achieved.
Owner:EAST CHINA UNIV OF SCI & TECH

N-CQDs lithium-ion imprinting sensor and preparation method and application thereof

InactiveCN109679013AMaterial greenThe material is green, environmentally friendly and pollution-freeFluorescence/phosphorescenceEthylenediamineFunctional monomer
The invention relates to an ion imprinting sensor, in particular to an N-CQDs lithium-ion imprinting sensor and a preparation method and application thereof, and belongs to the technical field of environmental material preparation. The preparation method includes the steps that cheap green citric acid (CA) is first taken as a carbon source, and ethylenediamine (EDA) is used for nitrogen doping toobtain nitrogen doped carbon quantum dots (N-CQDs) with good fluorescence performance; and then the N-CQDs are used for being combined with an ion imprinting technology (IIT), organic complexes of benzo 15 crown 5 (B15C5) and Li<+> are used as template ions, methanearsonic acid (MAA) is used as a functional monomer, EGDMA is used as a crosslinking agent, azobisisobutylntrile (ABIN) is used as an initiator, and a precipitation polymerization method is used, and the N-CQDs lithium-ion imprinting sensor (N-CQDs / IIP) is prepared and used for detection. The prepared N-CQDs lithium-ion imprinting sensor has good stability and optical performance, and has the ability to selectively identify lithium ions.
Owner:JIANGSU UNIV

Adsorbent for lithium isotope separation and preparation method and application thereof

The invention belongs to the field of lithium isotope separation, and in particular relates to an adsorbent for lithium isotope separation and its preparation method and application. The adsorbent is composed of porous polymer resin II and benzo-15-crown-5 compounds shown in formula (III), Wherein, R=H, nitro, amino, acrylamide, tert-butyl; the porous polymer resin II is XAD‑7, Amberchrom TM CG‑71, macroporous SiO 2 class carrier; the mass ratio of benzo-15-crown-5 compound and porous polymer resin II is 0.25-4. Its preparation method includes pretreatment, activation, dissolution and mixing. The adsorbent of the invention has a large separation coefficient for lithium isotopes, a simple preparation method, is easy to be applied in industry, and is environmentally friendly.
Owner:TSINGHUA UNIV

Preparation method of methane disulfonic acid

The invention discloses a preparation method of methane disulfonic acid. The preparation method comprises following steps: in the presence of a composite phase transfer catalyst, reacting sulfites with dibromomethane in water to obtain methane disulfonate; and carrying out acidification to obtain methane disulfonic acid; wherein the composite phase transfer catalyst comprises polyethylene glycol and other phase transfer catalysts other than polyethylene glycol; and other phase transfer catalysts are one or more of tetramethyl ammonium bromide, tetramethyl ammonium chloride, tetraethyl ammoniumbromide, tetraethyl ammonium chloride, tetrabutyl ammonium bromide, tetrabutyl ammonium chloride, benzyl triethyl ammonium chloride, cetyl trimethyl ammonium bromide, 18-crown-6, 15-crown-5, cyclodextrin, pyridine, and triethylamine. The preparation method can be performed at a low temperature under a normal pressure, is more environmentally-friendly, reduces energy consumption, and has the advantages of simple operation, safety, and ideal yield.
Owner:SUZHOU HUAYI NEW ENERGY TECH CO LTD

Cytosolic fluorescent ion indicators

Novel fluorophores for fluorescent ion indicators incorporate water-solubilizing functional groups. These fluorophores enable visible-wavelength analysis of ion concentrations with chelators that are insoluble or poorly soluble in water. A green version of the fluorophore comprises a putative fluorescein with carboxylate appendages. An orange version of the fluorophore comprises a putative rhodamine, also with carboxylate appendages. Attaching the fluorophore to a 12-crown-4, a 15-crown-5, a 18-crown-6, a 21-crown-7, or a 24-crown-8 produces lithium, sodium, potassium, rubidium, and cesium indicator families, respectively. Attaching the fluorophore to diaza [1,1,1], [1,1,2], [1,2,2], [2,2,2], [2,2,3], [2,3,3], or [3,3,3] cryptands produces more selective lithium, sodium, potassium, rubidium, and cesium indicator families, respectively. Attaching the fluorophore to BAPTA, APTRA, or half- BAPTA or their analogs produces new calcium, magnesium, and other metal ions indicator families that strongly resist leakage from the cell.
Owner:ASANTE RES

Preparation method of H-ZSM (Zeolite Socony Mobil)-20 molecular sieve

The invention relates to a preparation method of an H-ZSM (Zeolite Socony Mobil)-20 molecular sieve. The preparation method is characterized in that colloidal liquor is prepared from the following components in a molar ratio that SiO2:Al2O3:NaF:Na2O:15-Crown-5:18-Crown-6:H2O=(2-10):1.0:(0.5-1):(1-2.4):(0.0-0.5):(0.0-0.5):(10-100). The preparation method comprises the following specific steps: dissolving sodium hydroxide, haloid and aluminate in water, and magnetically stirring for 10 minutes to prepare liquor A; dropwise adding 30% silicon dioxide sol slowly into the liquor A, stirring for 30 minutes, then slowly adding a template, continuously stirring for 3 hours to obtain colloidal liquor, and standing for 24 hours at room temperature; transferring the colloidal liquor to a hydro-thermal synthetic reaction kettle, crystallizing for 10-20 days at 100-170 DEG C, cooling, filtering, washing, drying and grinding, heating to 450-600 DEG C through temperature programming and roasting for 3-10 ours to remove the template to obtain the molecular sieve ZSM-20; after ion exchange of the ZSM-20 by 0.1-2.0mol / L of ammonium nitrate liquor for 2-8 hours, repeatedly exchanging for 2-3 time; filtering, washing, drying and roasting to obtain the H-ZSM-20.
Owner:JILIN INST OF CHEM TECH

A kind of preparation method of nitrogen heterocycle

ActiveCN103232403BHave reactivityHigh reactivityOrganic chemistryTetramineBromine
The invention discloses a preparation method of azacyclo. The preparation method comprises the following steps of: (1) reacting diethylenetriamine or triethylene tetramine with methylsulfonyl chloride to generate methanesulfonamide; (2) during two-phase reaction, cyclizing compound catalytic cyclization on methanesulfonamide and a compound having the structure shown in a chemical formula (a) under the composite catalysis of benzyl triethylanmine compound and 15-crown-5 at 90 DEG C under a backflow condition; and (3) removing methylsulfonyl from methanesulfonamide azacyclo and performing methylation treatment, wherein X represents bromine, iodine or sulphonate. The preparation method has the advantages that raw materials are low in cost, atom economy is high, and operation is easy and safe. The preparation method is suitable for industrial production.
Owner:浙江凯普化工有限公司

Molybdenum compound of 15-crown-5 and MoO2Cl2(H2O)2, preparation method and application thereof

The invention relates to a molybdenum compound [MoO2Cl2(H2O)2][15C5] of 15-crown-5 and molybdenum, preparation method and application thereof. The molybdenum compound provided by the invention can prevent and inhibit the formation and growth of cancers and tumors, and can be used for preparation of drugs preventing and treating cancer and tumor diseases. Synthesis of the compound drug provided by the invention has the characteristics of easily available raw materials and low cost, the product precipitates out in the form of crystals, has high purity and yield, can stably exist under natural state, has good water solubility and lipid solubility, and presents excellent inhibition effect on A-549 (lung cancer), Bel-7402 (liver cancer), and HCT (colonic adenocarcinoma).
Owner:CAPITAL NORMAL UNIVERSITY

Corrosion-resistant glass flake resin

Corrosion-resistant glass flake resin includes a component A and a component B, wherein raw materials for preparing the component A include: allyl glycidyl ether, vinyl thiophene, mercaptosilane, aminosilane, vinyl benzimidazole, glass flakes, titanium dioxide , methyl isobutyl ketone, calcium carbonate and dimethyl silicone oil; raw materials for preparing the component B include: pentaerythritolglycidyl ether, 2-aminomethyl-15-crown-5 and tetrahydrofurfuryl alcohol; and the weight ratio of the component A to the component B is 1:(0.2-0.4).
Owner:江苏罗门扬环保工程有限公司

Liquid porous material for extracting methane as well as preparation method and application thereof

The invention discloses a liquid porous material for extracting methane as well as a preparation method and application thereof. The liquid porous material is prepared by taking 2,3-O-isopropylidene-D-threoatol, 1,4-dioxane, tetraethylene glycol di-p-toluenesulfonate, hydrochloric acid, triethylamine, dichloromethane, methylsulfonyl chloride, sodium azide, 15-crown-5, palladium on carbon, ethanol and the like as raw materials and performing a series of reaction, and is used for extracting the methane in rubbish landfill gas. The liquid porous material disclosed by the invention has the advantages of being high in methane recovery rate, high in reliability and renewable in recycling.
Owner:KUNMING UNIV OF SCI & TECH

Adsorbent for separating palladium from alkali metals and alkaline-earth metals and its preparation method and use

The invention discloses an adsorbent for separating palladium from alkali metals and alkaline-earth metals. 4-[3-(3-benzo-15-crown-5)methyl-4-hydroxy-phenyl]methylethyl-phenolic resin is supported by carriers to form the adsorbent. The 4-[3-(3-benzo-15-crown-5)methyl-4-hydroxy-phenyl]methylethyl-phenolic resin has a structural general formula (I), wherein in the structural general formula (I), n is an integer of 7-15. The carriers are porous silica gel or large-hole SiO2 coated by a polymer. The invention also discloses a preparation method and a use of the adsorbent for separating palladium from alkali metals and alkaline-earth metals. The preparation method has simple processes. The adsorbent obtained by the preparation method has good selectivity in palladium separation. The palladium separation process adopting the adsorbent is simple. The adsorbent has high separation efficiency and can be industrially produced easily.
Owner:ZHEJIANG UNIV
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