40 results about "15-Crown-5" patented technology

An improved process for the preparation of 2'-modified nucleosides and 2'-deoxy-nucleosides, such as, beta-L-2'-deoxy-thymidine (LdT), is provided. In particular, the improved process is directed to the synthesis of a 2'-deoxynucleoside that may utilize different starting materials but that proceeds via a chloro-sugar intermediate or via a 2,2' anhydro-1-furanosyl-nucleobase intermediate. Where an 2,2'-anhydro-1-furanosyl base intermediate is utilized, a reducing agent, such as Red-Al, and a sequestering agent, such as 15-crown-5 ether, that cause an intramolecular displacement reaction and formation of the desired nucleoside product in good yields are employed. An alternative process of the present invention utilizes a 2,2'-anhydro-1-furanosyl base intermediate without a sequestering agent to afford 2'-deoxynucleosides in good yields. The compounds made according to the present invention may be used as intermediates in the preparation of other nucleoside analogues, or may be used directly as antiviral and / or antineoplastic agents.

The invention relates to a preparation method of 15-crown 5-ether, which comprises the following steps: uniformly stirring triglycol and dioxane in a reaction vessel; adding sodium hydroxide and stirring, heating to 40-60 DEG C; adding a mixed liquor of dichloroethyl ether and dioxane at the temperature lower than 60 DEG C, reacting for 20-24 hours at the temperature of 60-90 DEG C; cooling to room temperature, centrifuging to obtain a filtrate; pumping the filtrate into the reaction vessel and distilling to obtain a distillation substrate; moving the distillation substrate to a stainless steel still, performing vacuum rectification, removing primary fraction to obtain the product. The preparation method has the beneficial effect that comparing with the prior art, the preparation method has the advantages of safe operation, low cost, little three wastes and high yield, and the primary fraction in the reaction can be reutilized.

An improved process for the preparation of 2'-modified nucleosides and 2'-deoxy-nucleosides, such as, beta-L-2'-deoxy-thymidine (LdT), is provided. In particular, the improved process is directed to the synthesis of a 2'-deoxynucleoside that may utilize different starting materials but that proceeds via a chloro-sugar intermediate or via a 2,2' anhydro-1-furanosyl-nucleobase intermediate. Where an 2,2'-anhydro-1-furanosyl base intermediate is utilized, a reducing agent, such as Red-Al, and a sequestering agent, such as 15-crown-5 ether, that cause an intramolecular displacement reaction and formation of the desired nucleoside product in good yields are employed. An alternative process of the present invention utilizes a 2,2'-anhydro-1-furanosyl base intermediate without a sequestering agent to afford 2'-deoxynucleosides in good yields. The compounds made according to the present invention may be used as intermediates in the preparation of other nucleoside analogues, or may be used directly as antiviral and / or antineoplastic agents.

The invention belongs to the technical field of sewage treatment, and the invention relates to a novel crown ether modified cellulose adsorbent capable of adsorbing heavy metals. First, graft polymerization is carried out on the surface of cellulose, after successful grafting of glycidyl methacrylate, and then ethylenediamine is used for epoxy ring opening, and then primary amine groups are introduced; tetraethylene glycol and 3,4 Synthesize 4-ethoxycarbonylbenzo-15-crown-5 with ethyl dihydroxybenzoate as raw material, then obtain carboxybenzocrown ether through hydrolysis and acidification, and then obtain acyl chloride benzocrown ether after acyl chloride , directly react with the primary amine on the branched cellulose chain after evaporating the solvent to realize the loading of the crown ether on the cellulose. The preparation has an adsorption effect on heavy metal copper. The product of the invention is beneficial to industrialized production.

A sodium crown ether-Salen xifokali isobimetal condensation complex, its preparation and use are disclosed. The complex consists of double active centers (a monomer consists of a catalytic active center and two modified active centers). The complex is prepared by condensation reacting 4, 5,-bi(2-hydroxy-benzal-imino)benzo-15-corona-5 with di-meta-dibenzo crown ether sulfonic acid to obtain solid condensed polymer and reacting the solid condensed polymer with transition metal to obtain final product. It has strong catalytic performance and can be used for catalytic molecular oxidation reaction.