40 results about "15-Crown-5" patented technology

An improved process for the preparation of 2'-modified nucleosides and 2'-deoxy-nucleosides, such as, beta-L-2'-deoxy-thymidine (LdT), is provided. In particular, the improved process is directed to the synthesis of a 2'-deoxynucleoside that may utilize different starting materials but that proceeds via a chloro-sugar intermediate or via a 2,2' anhydro-1-furanosyl-nucleobase intermediate. Where an 2,2'-anhydro-1-furanosyl base intermediate is utilized, a reducing agent, such as Red-Al, and a sequestering agent, such as 15-crown-5 ether, that cause an intramolecular displacement reaction and formation of the desired nucleoside product in good yields are employed. An alternative process of the present invention utilizes a 2,2'-anhydro-1-furanosyl base intermediate without a sequestering agent to afford 2'-deoxynucleosides in good yields. The compounds made according to the present invention may be used as intermediates in the preparation of other nucleoside analogues, or may be used directly as antiviral and / or antineoplastic agents.

The invention discloses a preparation method of azacyclo. The preparation method comprises the following steps of: (1) reacting diethylenetriamine or triethylene tetramine with methylsulfonyl chloride to generate methanesulfonamide; (2) during two-phase reaction, cyclizing compound catalytic cyclization on methanesulfonamide and a compound having the structure shown in a chemical formula (a) under the composite catalysis of benzyl triethylanmine compound and 15-crown-5 at 90 DEG C under a backflow condition; and (3) removing methylsulfonyl from methanesulfonamide azacyclo and performing methylation treatment, wherein X represents bromine, iodine or sulphonate. The preparation method has the advantages that raw materials are low in cost, atom economy is high, and operation is easy and safe. The preparation method is suitable for industrial production.

The invention relates to a preparation method of 15-crown 5-ether, which comprises the following steps: uniformly stirring triglycol and dioxane in a reaction vessel; adding sodium hydroxide and stirring, heating to 40-60 DEG C; adding a mixed liquor of dichloroethyl ether and dioxane at the temperature lower than 60 DEG C, reacting for 20-24 hours at the temperature of 60-90 DEG C; cooling to room temperature, centrifuging to obtain a filtrate; pumping the filtrate into the reaction vessel and distilling to obtain a distillation substrate; moving the distillation substrate to a stainless steel still, performing vacuum rectification, removing primary fraction to obtain the product. The preparation method has the beneficial effect that comparing with the prior art, the preparation method has the advantages of safe operation, low cost, little three wastes and high yield, and the primary fraction in the reaction can be reutilized.

An improved process for the preparation of 2'-modified nucleosides and 2'-deoxy-nucleosides, such as, beta-L-2'-deoxy-thymidine (LdT), is provided. In particular, the improved process is directed to the synthesis of a 2'-deoxynucleoside that may utilize different starting materials but that proceeds via a chloro-sugar intermediate or via a 2,2' anhydro-1-furanosyl-nucleobase intermediate. Where an 2,2'-anhydro-1-furanosyl base intermediate is utilized, a reducing agent, such as Red-Al, and a sequestering agent, such as 15-crown-5 ether, that cause an intramolecular displacement reaction and formation of the desired nucleoside product in good yields are employed. An alternative process of the present invention utilizes a 2,2'-anhydro-1-furanosyl base intermediate without a sequestering agent to afford 2'-deoxynucleosides in good yields. The compounds made according to the present invention may be used as intermediates in the preparation of other nucleoside analogues, or may be used directly as antiviral and / or antineoplastic agents.

The invention relates to a molybdenum compound [MoO2Cl2(H2O)2][15C5] of 15-crown-5 and molybdenum, preparation method and application thereof. The molybdenum compound provided by the invention can prevent and inhibit the formation and growth of cancers and tumors, and can be used for preparation of drugs preventing and treating cancer and tumor diseases. Synthesis of the compound drug provided by the invention has the characteristics of easily available raw materials and low cost, the product precipitates out in the form of crystals, has high purity and yield, can stably exist under natural state, has good water solubility and lipid solubility, and presents excellent inhibition effect on A-549 (lung cancer), Bel-7402 (liver cancer), and HCT (colonic adenocarcinoma).

The invention provides an extraction system for extracting lithium isotope. The system comprises an extracting agent, a hydrophobic ionic liquid and a diluent. The hydrophobic ionic liquid and the diluent are in the volume ratio of 1-15:1-10; the extracting agent has concentration in an extraction organic phase of 0.05-2.5mol / L; the extracting agent is at least one of benzo-15-crown-5 and a derivative thereof, or benzo-14-crown-4 and a derivative thereof. Compared with the crown ethers and pure ionic liquid system of the prior art, the system has the advantages of low operating costs and strong industry adaptability.

The invention belongs to the technical field of sewage treatment, and the invention relates to a novel crown ether modified cellulose adsorbent capable of adsorbing heavy metals. First, graft polymerization is carried out on the surface of cellulose, after successful grafting of glycidyl methacrylate, and then ethylenediamine is used for epoxy ring opening, and then primary amine groups are introduced; tetraethylene glycol and 3,4 Synthesize 4-ethoxycarbonylbenzo-15-crown-5 with ethyl dihydroxybenzoate as raw material, then obtain carboxybenzocrown ether through hydrolysis and acidification, and then obtain acyl chloride benzocrown ether after acyl chloride , directly react with the primary amine on the branched cellulose chain after evaporating the solvent to realize the loading of the crown ether on the cellulose. The preparation has an adsorption effect on heavy metal copper. The product of the invention is beneficial to industrialized production.

A sodium crown ether-Salen xifokali isobimetal condensation complex, its preparation and use are disclosed. The complex consists of double active centers (a monomer consists of a catalytic active center and two modified active centers). The complex is prepared by condensation reacting 4, 5,-bi(2-hydroxy-benzal-imino)benzo-15-corona-5 with di-meta-dibenzo crown ether sulfonic acid to obtain solid condensed polymer and reacting the solid condensed polymer with transition metal to obtain final product. It has strong catalytic performance and can be used for catalytic molecular oxidation reaction.

Corrosion-resistant glass flake resin includes a component A and a component B, wherein raw materials for preparing the component A include: allyl glycidyl ether, vinyl thiophene, mercaptosilane, aminosilane, vinyl benzimidazole, glass flakes, titanium dioxide , methyl isobutyl ketone, calcium carbonate and dimethyl silicone oil; raw materials for preparing the component B include: pentaerythritolglycidyl ether, 2-aminomethyl-15-crown-5 and tetrahydrofurfuryl alcohol; and the weight ratio of the component A to the component B is 1:(0.2-0.4).

The invention discloses an adsorbent for separating palladium from alkali metals and alkaline-earth metals. 4-[3-(3-benzo-15-crown-5)methyl-4-hydroxy-phenyl]methylethyl-phenolic resin is supported by carriers to form the adsorbent. The 4-[3-(3-benzo-15-crown-5)methyl-4-hydroxy-phenyl]methylethyl-phenolic resin has a structural general formula (I), wherein in the structural general formula (I), n is an integer of 7-15. The carriers are porous silica gel or large-hole SiO2 coated by a polymer. The invention also discloses a preparation method and a use of the adsorbent for separating palladium from alkali metals and alkaline-earth metals. The preparation method has simple processes. The adsorbent obtained by the preparation method has good selectivity in palladium separation. The palladium separation process adopting the adsorbent is simple. The adsorbent has high separation efficiency and can be industrially produced easily.