40 results about "15-Crown-5" patented technology

Belonging to the technical field of photoelectric phosphorescence materials, the invention discloses a preparation method of an iridium complex-containing phosphorescence material and its application in cobalt ion detection. With a general structural formula as shown in formula I, the iridium complex-containing phosphorescence material of the invention can be used for Co<2+> detection and comprises a main ligand and an auxiliary ligand, wherein, the main ligand is a derivative of 3, 4-disubstituted cinnoline, and the auxiliary ligand is a derivative of 15 crown-5 ether dipyridine. By means of the influence of Co<2+> on photo-physical and sensing properties of the iridium complex, the phosphorescence chemical sensor can observe the change of its phosphorescence emission spectrum so as to reach the Co<2+> detection purpose. The phosphorescence chemical sensor of the invention has the advantages of rapid phosphorescence response speed, easy differentiation from a fluorescence background, large range, high identification sensitivity to Co<2+>, good stability, and applicability for Co<2+> detection in various environments, and small interference from other positive ions, etc. Formula I is shown as the following.

An improved process for the preparation of 2′-modified nucleosides and 2′-deoxy-nucleosides, such as, β-L-2′-deoxy-thymidine (LdT), is provided. In particular, the improved process is directed to the synthesis of a 2′-deoxynucleoside that may utilize different starting materials but that proceeds via a chloro-sugar intermediate or via a 2,2′-anhydro-1-furanosyl-nucleobase intermediate. Where an 2,2′-anhydro-1-furanosyl base intermediate is utilized, a reducing agent, such as Red-Al, and a sequestering agent, such as 15-crown-5 ether, that cause an intramolecular displacement reaction and formation of the desired nucleoside product in good yields are employed. An alternative process of the present invention utilizes a 2,2′-anhydro-1-furanosyl base intermediate without a sequestering agent to afford 2′-deoxynucleosides in good yields. The compounds made according to the present invention may be used as intermediates in the preparation of other nucleoside analogues, or may be used directly as antiviral and/or antineoplastic agents.

The invention discloses application of benzo-azacrown ether compounds to separation of lithium isotopes. The benzo-azacrown ether compounds are selected from monoaza15-crown-5, bisaza15-crown-5, triaza15-crown-5 and bisaza18-crown-6. The benzo-azacrown ether compounds serving as extracting agents are dissolved in organic solvents to prepare organic phases, a lithium trifluoroacetate aqueous solution serves as an aqueous phase, and the lithium isotopes are separated at the room temperature by liquid-liquid extraction. The benzo-azacrown ether compounds are easy to dissolve in the organic solvents, efficient separation of the lithium isotopes can be realized by means of liquid-liquid extraction, and considerable separation factors, simplicity and convenience in operation, quickness in isotope exchange and technical simplicity are realized.

The invention belongs to the field of biological macromolecular probes, and particularly relates to a fluorescent reagent and a method for measuring human albumin and efficiently and quickly identifying the human albumin and bovine serum albumin. A schiff base organic compound with a typical torsion intramolecular charge transfer feature is designed and synthesized on the basis of a triphenylamine and 15-crown-5 ester structure, and is used as the fluorescent reagent; protein is added into a neutral phosphate buffer solution, the human albumin can be quickly identified from several types of common proteins according to compound fluorescent spectrum features, and a standard curve is established to quantitatively measure the contents of serum proteins in a buffered saline solution and artificial urine. The concentration of the probe reagent is 50mu M, and the 5mu M human albumin can be identified; after quantitative detection, the range of the human albumin in the buffered saline solution is 0 to 5.6mu M, and the minimum detection limit is 0.112mg/L; the range of the human albumin in the artificial urine is 0 to 1.2mu M, and the minimum detection limit is 1.95mg/L.

The invention relates to a crown ether cyclic quinazoline derivative and medicinal salts thereof using in tumor therapy and imaging. The crown ether cyclic quinazoline compound is characterized in that a 2-, 3-, 4- substituted aniline is disposed at one end; a 6-, 7- substituted crown ether cyclic quinazoline structure is disposed at the other end; the substituent group R1 is located on the fourth-position aniline of a quinazoline mother ring and is 2-, 3-, 4- substituted alkoxy; and the crown ether cycle is located at the 6, 7 position of the mother ring, and is a 9-crown-3, 12-crown-4 and 15-crown-5, and the structural formula is formula I. The experimental result of antitumor activity in vitro of nonradioactive isotope labeling compounds shows that the compounds are good in inhibitory effect for four kind of cancer cells namely HepG2, A549, sy5y and DU145, and have the potential as cancer treatment medicine; and the body distribution experiment of 18F or 125I labeling compounds show that the compounds are higher in ingestion and certain detention in tumors and faster in blood clearance and have potential applied to tumor imaging.

The invention belongs to the technical field of functional polymer membrane separation, and relates to a method for preparing a crown-ether graft polymer micro-porous membrane with a reaction-solution phase inversion control method. The method includes the steps that a chloromethyl-containing polymer such as polysulfone or polyether sulfone or polyether ether ketone is dissolved into a reaction solvent, an active-amido containing crown ether compound such as 4-aminobenzene-15-crown-5 is added, and a crown ether graft polymer is prepared through a nucleophilic substitution reaction between chloromethyl and amino; the grafting ratio of the reaction is controlled; in other words, when a reaction system is in certain viscosity, the reaction is terminated to prevent gelatinizing, the reaction system at the moment serves as a membrane casting solution, and the crown-ether graft polymer micro-porous membrane is prepared with the solution phase inversion method. As a cross bond exists in the polymer system, it can be achieved that the polymer micro-porous membrane which is high in porosity ratio and breaking strength is prepared under the low solid content of the polyether, and the separation step and the purification step of the grafted polymer are omitted; as a crown ether group exists, the polymer membrane has excellent lithium isotope separation performance.

A new crown ether ring-shaped quinazoline nitrogen mustard compound or a pharmaceutically-acceptable salt thereof is characterized in that: one end is provided with a nitrogen mustard alkylated group; the other end is provided with a 6,7-substituted crown ether ring-shaped quinazoline structure; a substituted group R is located at a site 4 of a quinazoline matrix and represents 2-nitrogen mustard group, 3-nitrogen mustard group or 4-nitrogen mustard group; a crown ether ring is located at sites 6 and 7 of the quinazoline matrix and represents 9-crown-3, 12-crown-4 or 15-crown-5; and the compound has a structure represented by a formula I. Experiments show that the compound has better antitumor activity and also has selectivity on different tumor cells. At the same time, the compound is easy to synthesize and simple in operation. Advantages of the compound show that the compound has great potential to become a drug for treatment of tumor.

The invention discloses a preparation method of a polyether macromonomer for a polycarboxylate water reducer. The preparation method comprises the following steps: (1) taking a part of methyl allyl alcohol to react with a catalyst one, then putting a reacted product into the remaining methallyl alcohol, and introducing ethylene oxide and propylene oxide for reaction, so that a methylallyl random oligomer is obtained; and (2) allowing the methylallyl random oligomer to react with a catalyst two and a catalyst three, and then introducing ethylene oxide and propylene oxide for reaction; wherein the catalyst one is one or more of sodium, potassium and sodium hydride; the catalyst two is one or more of 18-crown-6 and 15-crown-5; and the catalyst three is phosphonitrilic chloride trimer. Compared with the prior art, the preparation method of the polyether macromonomer for the polycarboxylate water reducer has the advantages that the effective content is high, the by-product content is low, the molecular weight distribution is narrow, the double bond retention rate is high, and the likes, wherein a molecular weight distribution coefficient is less than 1.05, and the double bond retentionrate is greater than 98.0%.

The invention belongs to the technical field of preparation of a ternary battery electrolyte, and particularly relates to a high-nickel ternary lithium battery electrolyte with cycling stability. According to the high-nickel ternary lithium battery electrolyte, an additive of the electrolyte is a mixture of dimethylaminoanisole, 4'-aminobenzo-15-crown-5-ether and sorbeth-n hexastearate, and by means of sorbeth-n hexastearate, the phenomenon of poor electrolyte infiltration caused by blockage by degradation products, breakage of battery cathode pores due to charge and discharge and the like canbe eliminated, so that cycle performance of a battery is improved; OCH3 of dimethylaminoanisole is subjected to a reaction of a solvolyte, LiOCH3 is generated, and an efficient and stable SEI (solidelectrolyte interface) film is formed; wrapped chelate is formed by 4'-aminobenzo-15-crown-5-ether and lithium ions, solubility of lithium salt can be improved, and effective separation of anion-cation pairs and separation of lithium ions and solvent molecules are realized; under the joint action of dimethylaminoanisole, 4'-aminobenzo-15-crown-5-ether and sorbeth-n hexastearate, the cycle performance of the electrolyte is improved.

The invention relates to a preparation method of 15-crown 5-ether, which comprises the following steps: uniformly stirring triglycol and dioxane in a reaction vessel; adding sodium hydroxide and stirring, heating to 40-60 DEG C; adding a mixed liquor of dichloroethyl ether and dioxane at the temperature lower than 60 DEG C, reacting for 20-24 hours at the temperature of 60-90 DEG C; cooling to room temperature, centrifuging to obtain a filtrate; pumping the filtrate into the reaction vessel and distilling to obtain a distillation substrate; moving the distillation substrate to a stainless steel still, performing vacuum rectification, removing primary fraction to obtain the product. The preparation method has the beneficial effect that comparing with the prior art, the preparation method has the advantages of safe operation, low cost, little three wastes and high yield, and the primary fraction in the reaction can be reutilized.

The invention relates to preparation and application of an asymmetric poly(phenyleneethynylene) oligomer with ion transmembrane transfer activity. The asymmetric poly(phenyleneethynylene) oligomer has a structural formula shown as the formula I (please see the formula I in the description), wherein R1 is selected from one of -CH2(CH2)4CH3, -CH2(CH2)6CH3, -CH2(CH2)8CH3, -CH2(CH2)10CH3, -OCH2CH2OCH2CH2O(CH2)5CH3 and -OCH2CH2OCH2CH2O(CH2)7CH3, R2 represents a cation recognition group or an anion recognition group, the cation recognition group is selected from one of benzo-15-crown-5, benzo-18-crown-6, hybridized nitrogen-15-crown-5, hybridized nitrogen-18-crown-6, dibenzo-15-crown-5 and dibenzo-18-crown-6, and the anion recognition group is selected from one of 2,6-pyridine diamide and isophthalic diamide. According to the asymmetric poly(phenyleneethynylene) oligomer, a single-molecule artificial ion channel is formed in a bi-layer membrane, ion transmembrane transfer is effectively achieved, a new method is sought for treating diseases related to function disorders of the ion channel, and the important application value in the field of antibacterial and anti-cancer biological medicine for treating diseases is achieved.

The invention belongs to the field of lithium isotope separation, and in particular relates to an adsorbent for lithium isotope separation and its preparation method and application. The adsorbent is composed of porous polymer resin II and benzo-15-crown-5 compounds shown in formula (III), Wherein, R=H, nitro, amino, acrylamide, tert-butyl; the porous polymer resin II is XAD‑7, Amberchrom ^TM CG‑71, macroporous SiO ₂ class carrier; the mass ratio of benzo-15-crown-5 compound and porous polymer resin II is 0.25-4. Its preparation method includes pretreatment, activation, dissolution and mixing. The adsorbent of the invention has a large separation coefficient for lithium isotopes, a simple preparation method, is easy to be applied in industry, and is environmentally friendly.

The invention discloses a preparation method of methane disulfonic acid. The preparation method comprises following steps: in the presence of a composite phase transfer catalyst, reacting sulfites with dibromomethane in water to obtain methane disulfonate; and carrying out acidification to obtain methane disulfonic acid; wherein the composite phase transfer catalyst comprises polyethylene glycol and other phase transfer catalysts other than polyethylene glycol; and other phase transfer catalysts are one or more of tetramethyl ammonium bromide, tetramethyl ammonium chloride, tetraethyl ammoniumbromide, tetraethyl ammonium chloride, tetrabutyl ammonium bromide, tetrabutyl ammonium chloride, benzyl triethyl ammonium chloride, cetyl trimethyl ammonium bromide, 18-crown-6, 15-crown-5, cyclodextrin, pyridine, and triethylamine. The preparation method can be performed at a low temperature under a normal pressure, is more environmentally-friendly, reduces energy consumption, and has the advantages of simple operation, safety, and ideal yield.

The invention relates to a molybdenum compound [MoO2Cl2(H2O)2][15C5] of 15-crown-5 and molybdenum, preparation method and application thereof. The molybdenum compound provided by the invention can prevent and inhibit the formation and growth of cancers and tumors, and can be used for preparation of drugs preventing and treating cancer and tumor diseases. Synthesis of the compound drug provided by the invention has the characteristics of easily available raw materials and low cost, the product precipitates out in the form of crystals, has high purity and yield, can stably exist under natural state, has good water solubility and lipid solubility, and presents excellent inhibition effect on A-549 (lung cancer), Bel-7402 (liver cancer), and HCT (colonic adenocarcinoma).

Corrosion-resistant glass flake resin includes a component A and a component B, wherein raw materials for preparing the component A include: allyl glycidyl ether, vinyl thiophene, mercaptosilane, aminosilane, vinyl benzimidazole, glass flakes, titanium dioxide , methyl isobutyl ketone, calcium carbonate and dimethyl silicone oil; raw materials for preparing the component B include: pentaerythritolglycidyl ether, 2-aminomethyl-15-crown-5 and tetrahydrofurfuryl alcohol; and the weight ratio of the component A to the component B is 1:(0.2-0.4).

The invention discloses a liquid porous material for extracting methane as well as a preparation method and application thereof. The liquid porous material is prepared by taking 2,3-O-isopropylidene-D-threoatol, 1,4-dioxane, tetraethylene glycol di-p-toluenesulfonate, hydrochloric acid, triethylamine, dichloromethane, methylsulfonyl chloride, sodium azide, 15-crown-5, palladium on carbon, ethanol and the like as raw materials and performing a series of reaction, and is used for extracting the methane in rubbish landfill gas. The liquid porous material disclosed by the invention has the advantages of being high in methane recovery rate, high in reliability and renewable in recycling.