15 crown 5 and moo 2 cl 2 (h 2 o) 2 Molybdenum compounds and their preparation and application

A molybdenum compound, mocl2o2 technology, applied in the field of biomedicine, can solve problems such as the instability of ammonium tetrathiomolybdate, and achieve the effects of excellent inhibition, high yield and high purity

Inactive Publication Date: 2016-09-28
CAPITAL NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But ammonium tetrathiomolybdate is unstable and extremely sensitive to light, water and oxygen

Method used

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  • 15 crown 5 and moo <sub>2</sub> cl <sub>2</sub> (h <sub>2</sub> o) <sub>2</sub> Molybdenum compounds and their preparation and application
  • 15 crown 5 and moo <sub>2</sub> cl <sub>2</sub> (h <sub>2</sub> o) <sub>2</sub> Molybdenum compounds and their preparation and application
  • 15 crown 5 and moo <sub>2</sub> cl <sub>2</sub> (h <sub>2</sub> o) <sub>2</sub> Molybdenum compounds and their preparation and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Example 1 with 0.8gNa 2 MoO 4 2H 2 O was put into a 50ml round-bottomed flask containing 15ml of anhydrous methanol and 15ml of acetonitrile, placed on an electromagnetic stirrer and stirred for 30min, then slowly dripped 30% HCl, and then added 0.5ml15C5 and continued to stir for 8h to 20h. Filter and pour the filtrate into a 25ml pressure vessel. Hydrothermal synthesis at 120°C for 48h to 72h, filter to obtain a light green clear liquid, put the clear liquid in a long test tube, slowly add ether along the test tube wall to twice the height of the filtrate, seal it and let it stand, and precipitate light green after about a week Crystal, namely the compound [MoCl 2 o 2 (H 2 O) 2 ][15C5], the structure is as follows:

[0031]

[0032] Among them, MoCl 2 o 2 (H 2 O) 2 The structure of the is as follows:

[0033]

[0034] The structure of 15C5 is as follows:

[0035]

[0036] Among them, [MoCl 2 o 2 (H 2 O) 2 The crystal structure of ][15C5] is ...

Embodiment 2

[0043] Example 2 Put 1 mole of molybdenum hexacarbonyl into a 50ml round bottom flask filled with 15ml methanol and 15ml acetonitrile, place it on an electromagnetic stirrer and stir for 30min, then slowly add 30% HCl, then add 0.5ml15C5 and continue stirring 8h to 20h. Filter and pour the filtrate into a 25ml pressure vessel. Hydrothermal synthesis at 120°C for 48h to 72h, filter to obtain a light green clear liquid, put the clear liquid in a long test tube, slowly add ether along the test tube wall to twice the height of the filtrate, seal it and let it stand, and precipitate light green after about a week Crystal, namely the compound [MoCl 2 o 2 (H 2 O) 2 ][15C5], its infrared spectrum / elemental analysis and molecular and crystal structure are the same as in Example 1.

Embodiment 3

[0044] Example 3 Put 1 mole of molybdenum tetrachloride into a 50ml round bottom flask containing 15ml methanol and 15ml acetonitrile, place it on an electromagnetic stirrer and stir for 30min, then slowly add 30% HCl, then add 0.5ml15C5 and continue stirring 8h to 20h. Filter and pour the filtrate into a 25ml pressure vessel. Hydrothermal synthesis at 120°C for 48h to 72h, filter to obtain a light green clear liquid, put the clear liquid in a long test tube, slowly add ether along the test tube wall to twice the height of the filtrate, seal it and let it stand, and precipitate light green after about a week Crystal, namely the compound [MoCl 2 o 2 (H 2 O) 2 ][15C5], its infrared spectrum / elemental analysis and molecular and crystal structure are the same as in Example 1.

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Abstract

The invention relates to a molybdenum compound [MoO2Cl2(H2O)2][15C5] of 15-crown-5 and molybdenum, preparation method and application thereof. The molybdenum compound provided by the invention can prevent and inhibit the formation and growth of cancers and tumors, and can be used for preparation of drugs preventing and treating cancer and tumor diseases. Synthesis of the compound drug provided by the invention has the characteristics of easily available raw materials and low cost, the product precipitates out in the form of crystals, has high purity and yield, can stably exist under natural state, has good water solubility and lipid solubility, and presents excellent inhibition effect on A-549 (lung cancer), Bel-7402 (liver cancer), and HCT (colonic adenocarcinoma).

Description

technical field [0001] The present invention relates to molybdenum compounds of 15 crown 5 and molybdenum [MoCl 2 o 2 (H 2 O) 2 ][15C5] and its preparation method and application, the present invention can prevent and inhibit the formation and growth of cancer and tumors, can be used to prepare drugs for the prevention and treatment of cancer and tumor diseases, and belongs to the field of biomedicine. Background technique [0002] The element molybdenum is an important trace element of life. Regional studies have shown that: in high-incidence areas such as esophageal cancer, digestive tract cancer, gastric cancer, liver cancer, rectal cancer, lung cancer, and breast cancer, such as Lin County in Henan, residents' serum, urine samples and The content of molybdenum in the hair is significantly lower than that in the low hair area. Animal experiments showed that after molybdenum-deficient animals and normal animals received a certain dose of nitroso compounds at the same t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D323/00C01G39/04A61K33/24A61K31/357A61P35/00
CPCC01G39/04C07D323/00
Inventor 鲁晓明闵涛王有林潘钢火
Owner CAPITAL NORMAL UNIVERSITY
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