Cefalexin capsule

A technology of cephalexin capsules and cephalexin, which is applied in directions such as capsule delivery and antibacterial drugs, can solve the problems of unstable chemical properties, easy hydrolysis of cephalexin, influence on medication safety, etc., and achieves rapid dissolution, good stability, and convenient administration. Effect

Inactive Publication Date: 2015-05-27
南京多宝生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, because cephalexin is a β-lactamase antibiotic, its chemical properties are unstable and easily hydrolyzed, which seriously affects product quality and even affects drug safety.
At presen

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Take each component by the following parts by weight:

[0025] 50 parts of cephalexin, 15 parts of corn starch, 10 parts of microcrystalline cellulose, 0.8 parts of sodium lauryl sulfate, 1.2 parts of poloxamer, 2.5 parts of ascorbic acid, 4 parts of talcum powder, and 1.5 parts of micronized silica gel.

[0026] Mix the above components evenly, crush them through a 120-mesh sieve, make granules, and put them into capsules.

Embodiment 2

[0028] Take each component by the following parts by weight:

[0029] 20 parts of cephalexin, 15 parts of sucrose, 10 parts of microcrystalline cellulose, 1 part of sodium lauryl sulfate, 1 part of poloxamer, 2.5 parts of ascorbic acid, 3 parts of magnesium stearate, and 1 part of micronized silica gel.

[0030] Mix the above components evenly, crush them through a 120-mesh sieve, make granules, and put them into capsules.

Embodiment 3

[0032] Take each component by the following parts by weight:

[0033] 15 parts of cephalexin, 10 parts of sorbitol, 10 parts of microcrystalline cellulose, 1.5 parts of sodium lauryl sulfate, 0.5 parts of poloxamer, 2 parts of ascorbic acid, 3 parts of talcum powder, and 1 part of micronized silica gel.

[0034] Mix the above components evenly, crush them through a 120-mesh sieve, make granules, and put them into capsules.

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PUM

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Abstract

The invention relates to a cefalexin capsule which comprises cefalexin and auxiliary materials. The auxiliary materials comprise filler, a disintegrating agent, a surfactant, a stabilizer, a lubricant and a glidant, wherein the surfactant is one or more of lauryl sodium sulfate, polysorbate-80, poloxamer, polyethylene glycol tricaprylin and polyethylene glycol stearin. The cefalexin capsule disclosed by the invention is short in disintegration time, and drugs dissolve out rapidly.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a cephalexin capsule. Background technique [0002] Cephradine (Cephradine, Velosef), also known as cephalosporin IV, cephalosporin IV, etc., is the first generation of semi-synthetic cephalosporins. ,7R)-3-methyl-7-[(R)-2-amino-2-phenylacetamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]octane-2 -ene-2-carboxylic acid. This product is acid-resistant and can be taken orally, with good absorption and high blood concentration. It is characterized by resistance to β-lactamase. This product has a good antibacterial effect on Neisseria, but Haemophilus influenzae is less sensitive to this product; The product has a certain antibacterial effect on some Escherichia coli, Proteus mirabilis, Salmonella and Shigella. The remaining Enterobacteriaceae, Acinetobacter, Pseudomonas aeruginosa, and Bacteroides fragilis all showed resistance to this product. Fusobacterium and Veillonella are...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K31/545A61K47/38A61P31/04
Inventor 李洋朱海燕
Owner 南京多宝生物科技有限公司
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