Mesoporous magnesium silicate-calcium sulfate hemihydrate composite material, and preparation method and application thereof

A technology of calcium sulfate hemihydrate and magnesium silicate, applied in the field of materials, can solve the problems of bone repair materials such as looseness, poor mechanical compatibility, and slow bone healing speed, and achieve accelerated bone healing, good bone conduction, and stimulation The effect of bone growth

Inactive Publication Date: 2015-05-27
EAST CHINA UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is to overcome the loosening and bone resorption of bone repair materials caused by stress shielding caused by the poor mechanical compatibility of existing bone repair materials, or the bone healing speed is too slow and lacks biological activity, which cannot be combined with Defects in the formation of strong bonds in bone

Method used

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  • Mesoporous magnesium silicate-calcium sulfate hemihydrate composite material, and preparation method and application thereof
  • Mesoporous magnesium silicate-calcium sulfate hemihydrate composite material, and preparation method and application thereof
  • Mesoporous magnesium silicate-calcium sulfate hemihydrate composite material, and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0059] A preparation method of mesoporous magnesium silicate, comprising the steps of:

[0060] (1) Mix 4.0g of P123 with 30mL of water until the solution is clear, add 120mL of hydrochloric acid with a concentration of 2mol / L at 50°C and stir for 1h, then add 9.6g of magnesium nitrate hexahydrate, and dissolve 9.12mL of Add TEOS dropwise to the solution at a rate of 15 drops / min, stir until the solution turns white and turbid, then continue to stir for 5 hours to obtain a sol-gel white emulsion;

[0061] (2) Aging the sol-gel white emulsion at 25°C for 3 days, then removing the supernatant by suction filtration, drying the precipitate at 80°C, and sintering at 600°C for 6 hours to obtain the product.

[0062] The scanning electron micrographs and transmission electron micrographs of the mesoporous magnesium silicate are shown in figure 1 (a), (b); the mesoporous magnesium silicate has a mesoporous pore diameter of 10nm-15nm, and the prepared mesoporous magnesium silicate is ...

Embodiment 2

[0065] (1) Mix 4.0g of P123 with 28mL of water until the solution is clear, add 140mL of hydrochloric acid with a concentration of 1mol / L at 50°C and stir for 1 hour, then add 9.6g of magnesium nitrate hexahydrate, and dissolve 9.12mL of Add TEOS dropwise to the solution at a rate of 15 drops / min, stir until the solution turns white and turbid, then continue to stir for 6 hours to obtain a sol-gel white emulsion;

[0066] (2) Aging the sol-gel white emulsion at 25°C for 3 days, then removing the supernatant by suction filtration, drying the precipitate at 80°C, and sintering at 550°C for 6 hours to obtain the product.

[0067] The parameter indexes of the mesoporous magnesium silicate prepared in this embodiment are the same as those in Example 1.

Embodiment 3

[0069] (1) Mix 4.0g of P123 with 30mL of water until the solution is clear, add 120mL of hydrochloric acid with a concentration of 2mol / L at 50°C and stir for 1 hour, then add 8.4g of magnesium nitrate hexahydrate, and dissolve 13.2mL of Add TEOS dropwise to the solution at a rate of 18 drops / min, stir until the solution turns white and turbid, then continue to stir for 7 hours to obtain a sol-gel white emulsion;

[0070] (2) Aging the sol-gel white emulsion at 25°C for 3 days, then removing the supernatant by suction filtration, drying the precipitate at 80°C, and sintering at 600°C for 6 hours to obtain the product.

[0071] The parameter indexes of the mesoporous magnesium silicate prepared in this embodiment are the same as those in Example 1.

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Abstract

The invention discloses a mesoporous magnesium silicate-calcium sulfate hemihydrate composite material, and a preparation method and application thereof. The preparation method comprises the following steps: (1) adding hydrochloric acid into a P123-water mixture, uniformly mixing, adding soluble magnesium salt, dropwisely adding TEOS (tetraethyl orthosilicate) into the solution, stirring until the solution has white turbidity, and continuing stirring to obtain a sol-gel white emulsion; (2) aging the white emulsion, carrying out vacuum filtration to remove the supernatant liquid, drying the precipitate, and sintering to obtain mesoporous magnesium silicate; and mixing the mesoporous magnesium silicate-calcium sulfate hemihydrate powder mixture with a solidifying solution, carrying out compression molding, solidifying and baking to obtain the calcium sulfate hemihydrate composite material. The calcium sulfate hemihydrate composite material has favorable application prospects in bone prosthesis, has favorable bioactivity and biocompatibility especially when being used as bone cement, and can stimulate the bone growth and shorten the healing time after implanting the material into the bone.

Description

technical field [0001] The invention relates to the field of materials, in particular to a composite material of mesoporous magnesium silicate and calcium sulfate hemihydrate and a preparation method and application thereof. Background technique [0002] At present, the clinically used bone implant materials are mostly titanium-based bone implant materials and ceramic bone implant materials, but these materials still have their own shortcomings that are difficult to overcome. The structural properties of metal materials are quite different from those of bone, lack of biological activity, cannot form osseointegration with bone, and easily cause bone resorption, and the dissolution of metal ions can easily lead to effusion, inflammation, and necrosis; while ceramic bone implant materials have Difficult to form and process, poor toughness and other disadvantages. Therefore, the research and development of new alternative products is particularly important. [0003] Calcium su...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B33/24A61L27/02A61L27/56
Inventor 魏杰丁月婷陈洁董谢平苏佳灿牛云飞曹烈虎
Owner EAST CHINA UNIV OF SCI & TECH
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