Veterinary Chinese and western medicinal compound orally-disintegrating micropowder tablet and preparation method thereof

A micropowder tablet and oral disintegration technology, applied in the field of veterinary drugs, can solve the problems of exacerbating bacillary dysentery and poisoning degree of young animals, not timely controlling the intensity of diarrhea, and no preventive measures, so as to reduce the influence of bacterial toxins and control them in time Diarrhea, the effect of enhancing the antibacterial effect

Active Publication Date: 2015-06-03
山东致泰医药技术有限公司
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  • Summary
  • Abstract
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  • Application Information

AI Technical Summary

Problems solved by technology

Its difficulty, on the one hand, is that the onset is early, the course of the disease is short, and there are no effective preventive measures; on the other hand, it is difficult to treat the disease after it occurs.
[0003] At present, the prevention and control of bacillary dysentery in young animals usually adopts symptomatic treatment, which not only prevents secondary infection by injecting antibacterial drugs, but also replenishes electrolytes and water; Acute, rapid development of the disease, often due to untimely control of diarrhea in young animals, severe diarrhea leads to dehydration, and eventually collapses and dies
The reason for this phenomenon is that on the one hand, the symptoms of diarrhea are not controlled in time or t

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Materials: norfloxacin and licorice extract (both are commercially available products); see the formula 1, formula 3 and formula 6 of Example 3 for disintegration auxiliary materials.

[0047] 。

[0048] Cases: 20 cases of naturally-occurring piglet white scour in a pig farm, 20 cases of natural-occurring lamb white scour in a sheep farm, 20 cases of natural calf white scour in a dairy farm, and 20 cases of naturally-occurring puppy white scour in a pet dog farm For example, sick animals have white, off-white or yellowish-white fishy and loose stools; the laboratory diagnosis is E. coli infection.

[0049] Method: According to the method of Example 3, prepare groups 1 to 3;

[0050] ; .

Embodiment 2

[0051] Example 2 The effect of different drug combinations on piglet white scour

Embodiment 3

[0052] Materials: Norfloxacin, Scopolamine Hydrobromide and Licorice Extract (all commercially available products); Electrolyte supplements (prepared according to the amount in Example 3);

[0053] Case: 100 cases of piglet white scour from a certain pig farm. The sick pig chops are white, off-white or yellowish-white, smelly and loose stools; the laboratory diagnosed E. coli infection.

[0054] Method: According to the method of Example 6 (the dosages of norfloxacin, scopolamine hydrobromide, licorice extract and electrolyte supplements are in accordance with Table 4), sample 1 to sample 4 were prepared;

[0055] .

[0056] Under the same feeding conditions, the sick pigs were randomly divided into test group 1, test group 2, test group 3, test group 4 and blank group; test group 1 to test group 4 use test product 1 to test product 4 at 1 tablet / kg ·Bw was directly delivered into the mouth of the piglets, once a day for 3 days; the blank group was raised according to the daily feedi...

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Abstract

The invention provides an orally-disintegrating micropowder tablet for treating bacterial diarrhea of a young livestock. The orally-disintegrating micropowder tablet comprises the following components in parts by weight: 2-10 parts of norfloxacin, 5-30 parts of a liquorice extract and 25-120 parts of an orally-disintegrating auxiliary material; preferably, the orally-disintegrating micropowder tablet further comprises 0.02-0.5 part of scopolamine hydrobromide, 0.06-3 parts of potassium chloride, 0.1-2 parts of magnesium stearate, 0.01-1 part of sodium dodecyl sulfate, 0.01-0.5 part of sodium glycyrrhizinate, 0.01-0.5 part of cream essence or fresh milk essence and 0.05-0.5 part of sodium glutamate. The invention further provides a preparation method. The preparation method comprises the following steps: firstly, mixing the norfloxacin and the liquorice extract; secondly, dissolving the scopolamine hydrobromide, the potassium chloride and the sodium glutamate; thirdly, mixing the above substances into a paste; finally, adding other substances to prepare the orally-disintegrating micropowder tablet. The orally-disintegrating micropowder tablet can avoid the young livestock from generating a stress reaction, has a good sterilizing effect and can control bacterial toxin; the components can generate synergy to improve the therapeutic effect.

Description

technical field [0001] The invention belongs to the field of veterinary medicines, in particular to a veterinary compound orally disintegrating micropowder tablet of traditional Chinese and western medicine and a preparation method thereof, more particularly to an orally disintegrating micropowder tablet for treating young livestock bacterial diarrhea and a preparation method thereof. technical background [0002] Young animal bacillary diarrhea (referred to as "young animal dysentery") is a technical problem that has plagued animal husbandry for a long time. Especially in recent years, both the incidence and the mortality rate of young animal bacillary dysentery have been increasing year by year trend. Its difficulty lies in its early onset, short course of disease, and no effective preventive measures on the one hand; on the other hand, it is difficult to treat after the disease occurs. [0003] At present, the prevention and control of bacillary dysentery in young animal...

Claims

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Application Information

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IPC IPC(8): A61K36/484A61K9/20A61P1/12A61P31/04A61P39/02A61P3/12A61K31/496A61K31/46
Inventor 丁晓刚
Owner 山东致泰医药技术有限公司
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