Veterinary Chinese and western medicinal compound orally-disintegrating micropowder tablet and preparation method thereof

Abstract

The invention provides an orally-disintegrating micropowder tablet for treating bacterial diarrhea of a young livestock. The orally-disintegrating micropowder tablet comprises the following components in parts by weight: 2-10 parts of norfloxacin, 5-30 parts of a liquorice extract and 25-120 parts of an orally-disintegrating auxiliary material; preferably, the orally-disintegrating micropowder tablet further comprises 0.02-0.5 part of scopolamine hydrobromide, 0.06-3 parts of potassium chloride, 0.1-2 parts of magnesium stearate, 0.01-1 part of sodium dodecyl sulfate, 0.01-0.5 part of sodium glycyrrhizinate, 0.01-0.5 part of cream essence or fresh milk essence and 0.05-0.5 part of sodium glutamate. The invention further provides a preparation method. The preparation method comprises the following steps: firstly, mixing the norfloxacin and the liquorice extract; secondly, dissolving the scopolamine hydrobromide, the potassium chloride and the sodium glutamate; thirdly, mixing the above substances into a paste; finally, adding other substances to prepare the orally-disintegrating micropowder tablet. The orally-disintegrating micropowder tablet can avoid the young livestock from generating a stress reaction, has a good sterilizing effect and can control bacterial toxin; the components can generate synergy to improve the therapeutic effect.

Description

technical field [0001] The invention belongs to the field of veterinary medicines, in particular to a veterinary compound orally disintegrating micropowder tablet of traditional Chinese and western medicine and a preparation method thereof, more particularly to an orally disintegrating micropowder tablet for treating young livestock bacterial diarrhea and a preparation method thereof. technical background [0002] Young animal bacillary diarrhea (referred to as "young animal dysentery") is a technical problem that has plagued animal husbandry for a long time. Especially in recent years, both the incidence and the mortality rate of young animal bacillary dysentery have been increasing year by year trend. Its difficulty lies in its early onset, short course of disease, and no effective preventive measures on the one hand; on the other hand, it is difficult to treat after the disease occurs. [0003] At present, the prevention and control of bacillary dysentery in young animal...

AI Technical Summary

Problems solved by technology

Its difficulty, on the one hand, is that the onset is early, the course of the disease is short, and there are no effective preventive measures; on the other hand, it is difficult to treat the disease after it occurs.

[0003] At present, the prevention and control of bacillary dysentery in young animals usually adopts symptomatic treatment, which not only prevents secondary infection by injecting antibacterial drugs, but also replenishes electrolytes and water; Acute, rapid development of the disease, often due to untimely control of diarrhea in young animals, severe diarrhea leads to dehydration, and eventually collapses and dies

The reason for this phenomenon is that on the one hand, the symptoms of diarrhea are not controlled in time or the intensity of diarrhea is not controlled enough; bacillary dysentery and the degree of poisoning; at the same time, it is not unrelated to the stress response to young animals caused by repeated injections of drug administration in the current prevention and control of this type of disease

For diseases that occur in the gastrointestinal tract, treatment by oral administration is more direct and effective; however, newborn young animals will not eat solid feed, or even swallow solid feed that is too large in size; existing common solutions, Although pastes, powders, and powders can be given by force-feeding, this method of administration is not only difficult and requires a lot of work, but also causes a lot of stress to the newborn pups.