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Novel plant polysaccharide protective flushing fluid

A new type of plant and flushing liquid technology, applied in the field of medicine, can solve the problems of no anti-inflammatory and antibacterial, hemostasis and tissue cell regeneration, single function of normal saline, poor biocompatibility, etc., achieving good cleaning effect, simple preparation process, Healing effect

Active Publication Date: 2015-06-17
HEBEI AINENG BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The first step in wound treatment is to rinse the wound. Currently, the commonly used flushing solution is physiological saline, but the function of normal saline is single, and it does not have the functions of anti-inflammatory, antibacterial, hemostasis, and promotion of tissue cell regeneration.
The preparation of chitosan into irrigation fluid is also widely used in clinical practice, but chitosan is made of animal-derived materials, which has poor biocompatibility and high safety risk

Method used

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  • Novel plant polysaccharide protective flushing fluid
  • Novel plant polysaccharide protective flushing fluid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1~3

[0021] formula

[0022] .

[0023] Preparation process: Dissolve oxidized cellulose with alkaline solution according to the formula listed in the table, add a certain amount of water for injection, adjust the pH to neutral with acidic solution, then add 0.9g sodium chloride, 0.033g diphosphate Potassium hydrogen phosphate and 0.067g disodium hydrogen phosphate, and finally make up to 100ml with water for injection, measure the pH value, filter, fill the filtrate, fill it with nitrogen, seal it, and get it.

preparation example

[0025] Preparation example for adjusting the amount of sodium chloride and pH buffering substances added: Weigh 2g of oxidized cellulose powder (carboxyl content 20%), add 40ml of sodium hydroxide solution with a mass concentration of 0.01g / ml, and stir to dissolve; after the dissolution is complete Add 30ml of water for injection, then adjust the pH to neutral with a nitric acid solution with a volume concentration of 0.5%; add sodium chloride, potassium dihydrogen phosphate and disodium hydrogen phosphate in sequence, stir and dissolve fully, and finally make up to 100ml with water for injection, and measure pH value, filtering, filling the filtrate, filling with nitrogen gas, sealing, and the product is ready. The addition amount of sodium chloride, pH buffer substance is shown in Table 1.

[0026] Table 1 Adding amount of sodium chloride and pH buffer substance

[0027] .

Embodiment 7~13

[0029] Preparation example of further adding glycerin: Weigh 2g of oxidized cellulose powder (carboxyl content 20%), add 40ml of sodium hydroxide solution with a mass concentration of 0.01g / ml, stir and dissolve; after the dissolution is complete, add 30ml of water for injection, and then use The hydrochloric acid solution with a volume concentration of 1% adjusts the pH to neutral; add 0.9g of sodium chloride, 0.033g of potassium dihydrogen phosphate, 0.067g of disodium hydrogen phosphate, glycerin, and thiourea or sodium bisulfite in sequence, and fully stir to dissolve. Finally, fill it up to 100ml with water for injection, measure the pH value, filter, fill the filtrate, fill it with nitrogen gas, and seal it to get ready. The amount of glycerin added is shown in Table 2.

[0030] Table 2 The addition amount of glycerin and thiourea or sodium bisulfite

[0031] .

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Abstract

The invention relates to a novel plant polysaccharide protective flushing fluid employing oxidized cellulose as a main component. The novel plant polysaccharide protective flushing fluid comprises the following components in percentage by weight: 0.1%-5% of oxidized cellulose, 0.8%-1.0% of sodium chloride, 0.01%-0.1% of a pH buffer material and the balance of injection water, wherein the pH range of the novel plant polysaccharide protective flushing fluid is 6.5-7.5. The novel plant polysaccharide protective flushing fluid provided by the invention has the functions of flushing a wound, stopping bleeding, inhibiting bacteria, promoting wound healing and preventing adhesion, and is good in stability and not easy to degrade.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a novel plant polysaccharide protective flushing liquid with oxidized cellulose as the main component. Background technique [0002] All kinds of trauma, such as knife wounds, traffic accidents, bleeding trauma, ulcerative trauma, etc., should be treated in time. Improper handling will cause wound bleeding, infection, suppuration, etc. The first step in wound treatment is to rinse the wound. Currently, the commonly used flushing solution is physiological saline, but the function of normal saline is single, and it does not have the functions of anti-inflammatory, antibacterial, hemostasis, and promotion of tissue cell regeneration. It is also widely used clinically to formulate chitosan into irrigation solution, but chitosan is made of animal-derived materials, which has poor biocompatibility and high safety risk. [0003] Oxidized cellulose is made of natural cellul...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/14A61P7/04A61P31/02A61P17/02A61K31/717A61K31/17A61K33/04
Inventor 王新光张志宝龚亚雄李素哲魏维伟刘俊英
Owner HEBEI AINENG BIOTECH CO LTD
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