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Core-shell structured quantum dot composite nanocrystalline fluorescence probe and preparation method thereof

A core-shell structure, fluorescent probe technology, applied in the field of preparation of nanomaterials, can solve the problems of unstable physical and chemical properties, luminescence properties are easily affected by the external environment, etc., to improve various properties, good stability and biological Compatibility, luminous efficiency improvement effect

Inactive Publication Date: 2015-06-24
UNIV OF JINAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

First of all, the present invention provides a method for preparing ZnSe-based quantum dot core-shell composite nanocrystals. The shell layer is a composite silica shell containing ZnS-like semiconductor clusters. By coating the composite silica shell, the quantum dots overcome the The physical and chemical properties of ordinary quantum dots are unstable, and the luminous performance is easily affected by the external environment. At the same time, the yield of quantum dots is significantly improved.

Method used

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  • Core-shell structured quantum dot composite nanocrystalline fluorescence probe and preparation method thereof
  • Core-shell structured quantum dot composite nanocrystalline fluorescence probe and preparation method thereof
  • Core-shell structured quantum dot composite nanocrystalline fluorescence probe and preparation method thereof

Examples

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Embodiment 1

[0031] (1) Preparation of ZnSe quantum dot solution

[0032] Under nitrogen protection, 0.01g NaBH 4 Dissolve 0.0061g of Se powder in 2 mL of distilled water, heat to 40°C, and obtain NaHSe solution after completely dissolving; take 0.0439 g of Zn(Ac) 2 Dissolve in 20 mL of distilled water, add 0.0737 g of reduced glutathione after it is completely dissolved, and adjust the pH to 11.5 with 1 mol / L NaOH solution to obtain a Zn precursor solution; transfer the Zn precursor into a three-necked flask NaHSe solution was quickly injected under the protection of nitrogen, and the oil bath was refluxed at 100°C. After magnetic stirring for 1 h, it was taken out and quickly cooled to room temperature in the refrigerator to obtain a colorless and transparent solution, which was the prepared ZnSe QDs solution.

[0033] (2) Core-shell structure ZnSe@SiO 2 Preparation of Composite Nanocrystals

[0034] The prepared ZnSe QDs solution was separated and precipitated with isopropanol and di...

Embodiment 2

[0037] (1) Preparation of ZnSe quantum dot solution

[0038] Under nitrogen protection, 0.0085g NaBH 4 Dissolve 0.0060 g of Se powder in 2 mL of distilled water, heat to 40°C, and obtain NaHSe solution after completely dissolving; take 0.0351 g of Zn(Ac) 2 Dissolve in 20 mL of distilled water, add 0.0903 g of reduced glutathione after it is completely dissolved, and adjust the pH to 11.8 with 1 mol / L NaOH solution to obtain a Zn precursor solution; transfer the Zn precursor into three The NaHSe solution was quickly injected into the bottle under the protection of nitrogen, and the oil bath was refluxed at 100 °C. After magnetic stirring for 1.5 h, it was taken out and placed in the refrigerator to cool rapidly to room temperature to obtain a colorless and transparent solution, which was the prepared ZnSe QDs solution.

[0039] (2) Core-shell structure ZnSe@SiO 2 Preparation of Composite Nanocrystals

[0040] The prepared ZnSe QDs solution was separated and precipitated with...

Embodiment 3

[0043] (1) Preparation of ZnSe@ZnS quantum dot solution

[0044] Firstly, ZnSe quantum dots were prepared by chemical co-precipitation method, and the preparation method was as described in the above-mentioned Example 1.

[0045] Take 15 mL of prepared ZnSe quantum dots, in which the concentration of ZnSe quantum dots is 2.7×10 -3 mol / L, add 0.0138 g Zn(Ac) 2 , 0.0277 g reduced glutathione and 0.01 g thiourea, adjust the pH value to 10.5 with the prepared NaOH solution with a concentration of 1 mol / L, under magnetic stirring, reflux the oil bath at 100°C, and react for 2 h after magnetic stirring Put it in the refrigerator and quickly cool it to room temperature to obtain light yellow water-soluble ZnSe@ZnS quantum dots with high luminous efficiency.

[0046] (2) Core-shell structure ZnSe@ZnS@SiO 2 Preparation of Composite Nanocrystals

[0047] The prepared ZnSe@ZnS QDs solution was separated and precipitated with isopropanol and dispersed into 15 mL of distilled water, i...

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Abstract

The invention belongs to the technical field of preparation of nanometer materials and bioanalysis detection, and particularly relates to a core-shell structured quantum dot composite nanocrystalline fluorescence probe and a preparation method thereof. The invention provides the preparation method for a ZnSe quantum dot core-shell structured composite nanocrystalline. The shell of the composite nanocrystalline is a composite silicon dioxide shell containing ZnS semiconductor clusters, and by the coating of the composite silicon dioxide shell, the photochemical stability and quantum yield of quantum dots are obviously improved; meanwhile, based on the fluorescence quenching effect of the quantum dots, the fluorescence probe used for detecting trance heavy metal ions is prepared. According to the preparation method disclosed by the invention, the reaction condition is mild, the operation method is simple, the prepared core-shell structured composite nanocrystalline has good physicochemistry stability and biocompatibility, and the prepared probe has very high sensibility and good stability, and has wide application prospect in the fields of biosensors, fluorescence probes, biomarkers and the like.

Description

technical field [0001] The invention belongs to the technical fields of nanomaterial preparation and biological analysis and detection, and in particular relates to a preparation method of a core-shell quantum dot composite nanocrystal and a probe thereof, which can be used to detect trace metal ions in a solution. Background technique [0002] Semiconductor quantum dots are mainly nanoparticles composed of II-VI or III-V elements with a size between 1-10 nm. When the size of the semiconductor material is smaller than or close to the exciton Bohr radius, the ion energy appears quantum Therefore, the optical properties of semiconductor quantum dots change with the particle size, and their luminous efficiency is also greatly improved compared with bulk materials. The preparation of quantum dots has always been a hot spot of concern. From organic phase to aqueous phase, from low fluorescence quantum yield to high fluorescence quantum yield, from short fluorescence lifetime to l...

Claims

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Application Information

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IPC IPC(8): C09K11/02C09K11/88B82Y30/00B82Y40/00B82Y20/00G01N21/64
Inventor 刘福田丁永玲孙康宁綦育仕闫君
Owner UNIV OF JINAN
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