Medical titanium metal implant material and preparation method thereof

A technology of titanium metal and implants, which is applied in the field of medical titanium implant materials and its preparation, can solve the problems of long-term injection and the production of drug-resistant strains, and achieve good biological activity

Inactive Publication Date: 2015-08-12
HUBEI UNIV
View PDF3 Cites 30 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main clinical solution is to inject antibiotics, but antibiotic injections are specific, require long-term injections and will produce drug-resistant strains

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Medical titanium metal implant material and preparation method thereof
  • Medical titanium metal implant material and preparation method thereof
  • Medical titanium metal implant material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0028] The second aspect of the present invention provides a method for preparing a medical titanium metal implant material 100, comprising the following steps:

[0029] A. Use titanium metal 1 as the anode, use the solution containing F- as the electrolyte, react for 1-8h at a voltage of 20-40V, and a temperature of 30-60°C, wash and dry, and obtain a matrix row on the surface. Cloth of titanium dioxide nanotubes 2 of titanium metal 1;

[0030] B. loading anti-inflammatory and antibacterial drugs 4 in the titanium dioxide nanotubes 2 obtained in step A;

[0031] C. Coating the degradable polymer 3 solution on the end faces of the titanium dioxide nanotubes 2 arranged in a matrix, and drying to obtain the target product.

[0032] The degradable polymer 3 is one or a mixture of two or more of the following materials: glycolide / lactide copolymer, polyglycolic acid, polylactic acid, polycaprolactone and chitosan. Preferably, the mass volume ratio of the degradable polymer 3 sol...

Embodiment 1

[0041] step one,

[0042] For sample pretreatment, polish and polish the pure titanium metal sheet, place it in acetone and ultrasonically clean it for about 30 minutes, then ultrasonically clean it in deionized water for about 20 minutes, and set it aside.

[0043] step two,

[0044] The configuration of the etchant, the etchant consists of 10% HF and 40% HNO by volume 3 and 50%H 2 O mixed. spare.

[0045] Step three,

[0046] Configuration of electrolyte solution during anodic oxidation reaction, its composition is 0.3wt% NH 4 F, 3vol%H 2 O ethylene glycol solution, spare.

[0047] step four,

[0048] Configure a degradable polymer solution. The degradable polymer used in this case is lactide-glycolide copolymer (PLGA), the solvent used is chloroform, and the weight-to-volume concentration is 1%, for later use.

[0049] step five,

[0050] For sample encapsulation, copper wire is wrapped around the sample, and the back of the sample is coated with epoxy resin until...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
thicknessaaaaaaaaaa
Login to view more

Abstract

The invention provides a medical titanium metal implant material and a preparation method thereof. The medical titanium metal implant material includes a titanium metal, titania nanotubes grown on the titanium metal surface in a matrix arrangement, a biodegradable superpolymer coating the end face of a titania nanotube layer in the matrix arrangement and sealing the titania nanotubes, and an anti-inflammatory antibacterial drug loaded in the titania nanotubes. The medical titanium metal implant material has the characteristics of being high in drug loading capacity and capable of making drug properties of the drug slowly released.

Description

technical field [0001] The invention belongs to the field of medicine and medical equipment, and relates to a medical titanium metal implant material and a preparation method thereof. Background technique [0002] Due to the acceleration of the aging of the global population, the number of cases of osteoporosis and fractures has increased; coupled with the increase in trauma caused by natural disasters, traffic accidents, and work-related injuries, the demand for medical implant materials has increased. In the United States, there are more than 600,000 joint and bone surgical implants performed annually; in Europe, there are more than 400,000 human hard tissue surgical implants performed each year. About 2 million sets of spinal implant systems are used in the world, and it is growing at a rate of 14% per year; the annual growth rate of artificial joint replacement in my country is as high as 30%. injured patients. It can be seen that medical implant materials have great po...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/06A61L27/34A61L27/54A61L27/50
Inventor 吴水林刘想梅翁正阳李霞杨伟国
Owner HUBEI UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap