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Organic compound-derived magnetic carbon nanomaterial with metallic framework and application of organic compound-derived magnetic carbon nanomaterial

A technology of organic compounds and metal skeletons, applied in alkali metal compounds, alkali metal oxides/hydroxides, inorganic chemistry, etc., can solve problems that need to be further developed and improved, and achieve low detection limit, high reproducibility, The effect of shortening the extraction time

Inactive Publication Date: 2015-08-19
云南健牛环境监测有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing enrichment methods such as lectin affinity chromatography and hydrazide chemical solid-phase extraction are relatively mature and are currently the most widely used methods for enriching glycoproteins. However, high-efficiency, high-throughput glycoprotein separation and analysis The new technology still needs to be further developed and improved

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] 1. Preparation of divalent cobalt (II)-2-methylimidazole magnetic carbon nanomaterials:

[0027] 0.5mmol / mL CoCl 2 ·6H 2 O methanol solution 3mL mixed with 5.0mmol / mL 2-methylimidazole methanol solution 1mL, add 0.50mmol / mL polyvinylpyrrolidone methanol solution 1.5mL, stir at room temperature for 8h, stand for 16h, the purple precipitate produced is centrifuged, and Methanol was washed 3 times, dried at 80°C for 24h to obtain divalent cobalt (II)-2-methylimidazole metal skeleton organic compound; this metal skeleton organic compound was calcined at 700°C for 6h under nitrogen protection to obtain divalent cobalt ( II) - 2-methylimidazole magnetic carbon nanomaterials.

[0028] 2. Characterization of divalent cobalt(II)-2-methylimidazole magnetic carbon nanomaterials:

[0029] The whisker morphology of the synthesized materials was characterized by scanning electron microscope (SEM) and transmission electron microscope (TEM). The results show that the particle size ...

Embodiment 2

[0033] 1. Preparation of divalent cobalt(II)-terephthalic acid magnetic carbon nanomaterials:

[0034] 0.8mmol / mLCo(NO 3 ) 2 ·6H 2 O methanol solution 3mL mixed with 6.0mmol / mL terephthalic acid methanol solution 2mL, add 0.80mmol / mL polyvinylpyrrolidone methanol solution 2mL, stir at room temperature for 6h, stand for 24h, the resulting precipitate was centrifuged and washed with methanol for 4 Once, dry at 60°C for 30h to obtain divalent cobalt(II)-terephthalic acid metal skeleton organic compound; this metal skeleton organic compound is calcined at 500°C for 8h under the protection of nitrogen to obtain divalent cobalt(II)-terephthalic acid Phthalic acid magnetic carbon nanomaterials.

[0035] 2. Characterization of divalent cobalt(II)-terephthalic acid magnetic carbon nanomaterials:

[0036] The whisker morphology of the synthesized materials was characterized by scanning electron microscope (SEM) and transmission electron microscope (TEM). The results show that the p...

Embodiment 3

[0040] 1. Preparation of ferric (III)-4,4`-biphenyldicarboxylic acid magnetic carbon nanomaterials:

[0041] 1.0mmol / mL Fe(NO 3 ) 3 ·6H 2 Mix 2 mL of O methanol solution with 1.5 mL of 5.0 mmol / mL 4,4`-biphenyl dicarboxylic acid methanol solution, add 2.0 mL of 1.0 mmol / mL polyvinylpyrrolidone methanol solution, stir at room temperature for 7 h, and place it for 22 h, the resulting precipitate Centrifuge, wash with methanol 5 times, and dry at 60°C for 24 hours to obtain ferric (III)-4,4`-biphenyl dicarboxylic acid metal skeleton organic compound; Calcined for 5 hours to obtain ferric (III)-4,4'-biphenyldicarboxylic acid magnetic carbon nanomaterials.

[0042] 2. Characterization of ferric (III)-4,4`-biphenyldicarboxylic acid magnetic carbon nanomaterials:

[0043] The whisker morphology of the synthesized materials was characterized by scanning electron microscope (SEM) and transmission electron microscope (TEM). The results show that the particle size of the material va...

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Abstract

The invention discloses an organic compound-derived magnetic carbon nanomaterial with a metallic framework and application of the organic compound-derived magnetic carbon nanomaterial, and belongs to the technical field of organic nanomaterials. The organic compound-derived magnetic carbon nanomaterial is prepared by the following steps: with cobalt (II) and ferrum (III) as central ions, 2-methylimidazole, terephthalic acid and 4,4'-diphenic acid as ligands, and polyvinylpyrrolidone as dispersing agents, forming a cobalt-based and ferrum-based metallic framework organic compound in a self-assembly manner at room temperature; and with the cobalt-based and ferrum-based metallic framework organic compound as a template, carrying out high-temperature calcining under nitrogen protection, so as to obtain the magnetic carbon nanomaterial. The organic compound-derived magnetic carbon nanomaterial is applied to a separation carrier of N-glycoprotein; through the interaction between a large number of carbon and glycosyl of a nano-scale magnetic carbon material, appropriate mesopores and high specific surface, a novel method for simply and rapidly extracting the N-glycoprotein from a biological sample is built; and by combination with a biological mass spectrometry detection method, the condition that the synthetic magnetic carbon nanomaterial has high repeatability, significant specificity, high enrichment factor and low detection limit on the N-glycoprotein is proved.

Description

technical field [0001] The invention belongs to the technical field of organic nanometer materials. Background technique [0002] Metal-organic frameworks (MOFs) are a new type of material, which are usually hybridized by metal ions and oxygen-containing, nitrogen-containing multi-dentate organic ligands through a self-assembly process, and have a three-dimensional periodic network structure of regular nanopores. Compared with other porous materials, MOFs materials have large specific surface area, high porosity, regular and adjustable pore structure, and easy-to-functional framework metal ions and organic ligands, so they are widely used in catalysis research, gas adsorption, biomedicine , Magnetic functions and other fields have potential application value. [0003] Protein glycosylation is one of the most important and common post-translational modifications of proteins. Glycosylation participates in various biological processes by changing various biological properties...

Claims

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Application Information

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IPC IPC(8): B01J20/282B01J20/28B01J20/30B01D15/08G01N1/34G01N1/40
Inventor 杨亚玲廖文龙
Owner 云南健牛环境监测有限公司
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