Degradable composite nanofiber and its preparation method and use

A technology of composite nanofibers and electrospinning, which is applied in the field of tissue engineering in internal medicine to achieve the effects of uniform distribution, large specific surface area, and simple and controllable preparation methods

Active Publication Date: 2017-01-04
苏州金莱特化纤有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Therefore, simply using composite nanofibrous materials of polylactic acid, polytrimethylene carbonate and polyε-caprolactone electrospinning materials cannot solve many problems of the prior art

Method used

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  • Degradable composite nanofiber and its preparation method and use
  • Degradable composite nanofiber and its preparation method and use

Examples

Experimental program
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Effect test

Embodiment 1

[0029] First, dry pentaerythritol PTOL in a vacuum oven at 40°C overnight; prepare stannous octoate as a dilute solution in toluene, and recrystallize LLA with ethyl acetate, and dry it in vacuum for later use. Under nitrogen protection, the monomer LLA and the initiator PTOL were added to the reaction vessel, followed by the catalyst stannous octoate; wherein the monomer concentration was 0.3mg / L, and the molar ratio of the monomer LLA to PTOL was 40:1 , the molar ratio of stannous octoate to PTOL is 1:12. Then add toluene dried under reflux with sodium as a solvent, and react at 100°C for 42 hours to obtain star-shaped polylactic acid. The obtained star-shaped polylactic acid was dissolved in dichloromethane, precipitated with anhydrous methanol, and dried in a vacuum drying oven for 24 hours after the solvent evaporated.

[0030] The obtained product is characterized by HNMR, and there are three proton peaks, which are 5.23ppm, 3.79ppm and 1.60ppm respectively; wherein, 5....

Embodiment 2

[0034] First, dry pentaerythritol PTOL in a vacuum oven at 40°C overnight; prepare stannous octoate as a dilute solution in toluene, and recrystallize LLA with ethyl acetate, and dry it in vacuum for later use. Under the protection of nitrogen, the monomer LLA and the initiator PTOL were added to the reaction vessel, and then the catalyst stannous octoate was added; wherein, the monomer concentration was 0.5 mg / L, and the molar ratio of the monomer LLA to PTOL was 100:1 , the molar ratio of stannous octoate to PTOL is 1:14. Then add toluene dried under reflux with sodium as a solvent, and react at 120°C for 54 hours to obtain star-shaped polylactic acid. The obtained star-shaped polylactic acid was dissolved in dichloromethane, precipitated with anhydrous methanol, and dried in a vacuum drying oven for 24 hours after the solvent evaporated.

[0035] Use gel permeation chromatography GPC to measure the number average molecular weight Mn=4.2*10 of gained star polylactic acid 4...

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Abstract

The invention discloses a degradable composite nanofiber. The composite nanofiber is prepared from star-shaped poly(L-lactide), poly trimethylene carbonate and poly epsilon-caprolactone through an electrostatic spinning method, wherein the weight ratio of the three components is (40-60) to (10-30) to (20-40). The degradable composite nanofiber is characterized in that the star-shaped poly(L-lactide) takes pentaerythritol as a core. The invention further discloses a preparation method and application of the degradable composite nanofiber. The degradable composite nanofiber is small in diameter, uniform in distribution and large in specific surface area, has excellent mechanical property and biodegradation property, can meet demands of tissue engineering material, and is beneficial to the adhesion, growth and differentiation of cells. Meanwhile, the preparation method is simple and controllable, and is beneficial to batch industrial production.

Description

technical field [0001] The invention belongs to the field of tissue engineering of internal medicine and relates to a degradable composite nanofiber used in internal medicine and its preparation method and application. Background technique [0002] Due to their good biocompatibility and bioabsorbability, biodegradable polymer materials have been widely used in orthopedic fixation materials, drug sustained-release systems, intelligent sutures, medical devices, and tissue engineering. In the field of tissue engineering, by preparing biocompatible and degradable polymer scaffolds as an alternative material for tissue repair, it not only avoids the physical and mental trauma of surgical operations, but also greatly reduces the cost of tissue replacement. cost. Therefore, many studies are devoted to finding new biodegradable polymer materials with good properties and their preparation methods. [0003] The electrospinning technology developed in recent years can prepare biodegr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): D01F8/14C08G63/08A61L27/26A61L27/50
Inventor 曹菁
Owner 苏州金莱特化纤有限公司
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