Bioabsorbable bone repair material and its use and manufacturing method

A bone repair and biological technology, applied in the field of artificial prosthesis, can solve the problems of poor mechanical strength, difficult processing, and poor toughness of polylactic acid materials, achieve good biocompatibility, avoid side effects, and enhance the effect of mechanical strength

Inactive Publication Date: 2015-11-04
DONGGUAN TIAN TIAN XIANG SHANG MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] High molecular polylactic acid (polylactide, PLA) has good thermoformability, and its degradation rate can be adjusted by adjusting molecular weight and structure to meet different clinical requirements, so it can basically meet the needs of cell growth in the field of bone tissue engineering. Material requirements, but the mechanical strength of polylactic acid material is poor, and the degradation product is slightly acidic, there are two major disadvantages in the implanted device / prosthetic material made of it: First, the polylactic acid material will produce acidity when it degrades in the body These products will cause non-infectious inflammation (poor biocompatibility) of implanted surrounding tissues; secondly, the existing polylactic acid materials lack sufficient mechanical strength to meet the normal needs of human organs, especially bone organs
However, the disadvantages of apatite single crystal, such as fragility, poor strength, poor toughness and difficult processing, restrict its clinical application.

Method used

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  • Bioabsorbable bone repair material and its use and manufacturing method
  • Bioabsorbable bone repair material and its use and manufacturing method
  • Bioabsorbable bone repair material and its use and manufacturing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] A bioabsorbable skull repair material, the composition of the skull repair prosthesis is a compound of 10kg of bioabsorbable polyester polymer (polyglycolide) and 90kg of calcium phosphate (amorphous calcium phosphate (ACP)) .

[0043] The composite material constituting the absorbable skull prosthesis can be obtained by polymer and nano-processing techniques, such as high-speed mixer, twin-screw extruder extrusion, etc., or by chemically suspending nanoparticles in polymer materials.

[0044] The preparation method of the prosthetic bone is an injection molding method:

[0045] A. Digitize the CT / MRI image of the injured skull and convert it into a CAD file;

[0046] B. On the injection molding machine, according to the above-mentioned transformed CAD file, the above-mentioned bioabsorbable bone repair material is injected into a model of the damaged skull;

[0047] The prepared resorbable skull is coated with bone growth-inducing substances (damaging the patient's o...

Embodiment 2

[0049] A bioabsorbable bone repair material, the composition of the skull repair prosthesis is a composite of 20kg of bioabsorbable polyester polymer (polylactic acid (PLA)) and 80kg of calcium phosphate (dicalcium phosphate (DCP)).

[0050] The composite material constituting the absorbable cranial prosthesis can be obtained by polymer and nano-processing technology, such as high-speed mixer, twin-screw extruder extrusion, etc., or by chemically suspending nanoparticles in polymer materials.

[0051] The preparation method of the prosthetic bone:

[0052] A. Convert the CT / MRI image data of the injured skull into STL files with open source software, or other files recognizable by 3D printers, and establish a model of the injured skull;

[0053] B. Processing the bioabsorbable bone repair material into a wire that can be used by a 3D printer.

[0054] C. Use the melting and sintering method to process the wire material in B, and according to the model established in A, sinter...

Embodiment 3

[0057] A bioabsorbable bone repair material, the composition of the skull repair prosthesis is a composite of 30kg of bioabsorbable polyester polymer (poly-L-lactic acid (PLLA)) and 70kg of calcium phosphate (tricalcium phosphate (TCP)) .

[0058] The preparation method is the same as in Example 1, and the prepared absorbable skull bone fragment is implanted into the injured skull of the patient.

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Abstract

The invention relates to a bioabsorbable bone repair material and its use and manufacturing method. The bioabsorbable bone repair material is prepared from a bioabsorbable polyester polymer and calcium phosphate. Through injection molding and material increasing manufacture (3D printing), the bioabsorbable bone repair material can be processed to form desired prosthesis bone, the surface of the prosthesis bone is coated with a bone induction promoting substance and the coated prosthesis bone is implanted into a limb. The prosthesis bone prepared from the bioabsorbable bone repair material can be used for fast and individular repair of bone injuries caused by various reasons, has good biocompatibility and has enough mechanical strength and bone induction functions.

Description

technical field [0001] The invention belongs to the technical field of artificial prostheses, and in particular relates to a bioabsorbable bone repair material and its application and production method in bone repair. Background technique [0002] Bone defects caused by various reasons in bed are very common. It is estimated that traumatic fractures, spinal degenerative diseases, bone tumors, bone tuberculosis and other orthopedic diseases are caused by traffic accidents and production safety accidents in my country every year, resulting in more than 3 million patients with bone defects or dysfunction. It has become the consensus of orthopedic surgeons to repair and shape bone defects clinically. [0003] Clinical requirements for ideal bone repair materials include: (1) Good biocompatibility: In addition to meeting the general requirements of medical materials (such as non-toxic, non-teratogenic, etc.), it is also conducive to the adhesion, proliferation, and degradation o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/18A61L27/12A61L27/58A61L27/54A61L27/38A61L27/28A61L27/34B29C69/02B33Y10/00B33Y80/00
CPCA61L27/12A61L27/18A61L27/54A61L27/58B33Y10/00B33Y80/00
Inventor 吴天根
Owner DONGGUAN TIAN TIAN XIANG SHANG MEDICAL TECH
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