Acotiamide hydrochloride sustained-release drug and preparation method thereof

A technology of acotiamide hydrochloride and sustained-release agent, which is applied in the field of medicine, can solve problems such as easy forgetting, and achieve the effects of good compliance, easy swallowing, and easy preservation

Inactive Publication Date: 2015-11-18
叶澄
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In this way, the patient needs to take the medicine frequently, and it needs t

Method used

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  • Acotiamide hydrochloride sustained-release drug and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Preparation of collagen membrane solution:

[0039] (61) Extraction of crude collagen: Soak 1kg of eel bone in 4kg of 0.05mol / L sodium hydroxide solution for 20 hours, then rinse with clean water until neutral; then stir and soak in 10kg of 0.05mol / L hydrochloric acid solution for 3 hours Rinse with water until neutral, and grind to prepare crude collagen;

[0040] (62) Preparation of membrane solution: add 120mL of distilled water to 40g of crude collagen, extract at 80°C, and filter out insoluble substances. .

Embodiment 2

[0042] Prepare acotiamide hydrochloride sustained-release tablet according to the prescription in table 1:

[0043] (1) Weigh acotiamide hydrochloride, starch, dextrin, and sodium carboxymethyl starch through an 80-mesh sieve, mix well, and set aside;

[0044] (2) Weigh hydroxypropyl cellulose and slowly add it to water at a temperature above 50°C, stir to disperse evenly, cool to room temperature, and set aside;

[0045] (3) Add the binder aqueous solution prepared in step (2) to the mixed powder in step (1) to prepare a soft material. The soft material is wet granulated through a 24-mesh sieve, and the wet granules are dried at 50°C ;

[0046] (4) Pass the dry granules through a 24-mesh sieve for granulation, add magnesium stearate, and mix;

[0047] (5) According to the theoretical tablet weight (each tablet contains 150 mg of acotiamide hydrochloride), press to obtain ellipsoidal plain tablets;

[0048] (6) Take the vegetarian tablet, add the film solution (obtained by ...

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Abstract

The invention discloses an acotiamide hydrochloride sustained-release drug. The acotiamide hydrochloride sustained-release drug only needs to be taken once every morning. The acotiamide hydrochloride sustained-release drug has the advantages of quick effect, good sustained-release effect, good curative effect and less adverse reactions. A collagen membrane is utilized for coating acotiamide hydrochloride and other pharmaceutically acceptable auxiliary materials, wherein a weight ratio of acotiamide hydrochloride to the collagen membrane is 1:(1-1.5).

Description

technical field [0001] The invention relates to a sustained-release agent, in particular to an acotiamide hydrochloride sustained-release agent and a preparation method thereof. It belongs to the field of medical technology. Background technique [0002] Functional dyspepsia (FD) refers to a group of clinical syndromes caused by gastric and duodenal dysfunction, the main symptoms include one of epigastric pain, epigastric burning sensation, postprandial fullness and early satiety Or multiple, there may be epigastric distension, belching, loss of appetite, nausea, vomiting, etc., and the organic diseases that cause these symptoms can be ruled out after examination. FD is the most common functional gastrointestinal disease in clinical practice, accounting for more than 1 / 3 of gastrointestinal specialist outpatient clinics. The prevalence rate in western countries is about 20%~40%, and the prevalence rate in Chinese community population is 18.9%~ 19.8%. [0003] Acotiamide H...

Claims

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Application Information

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IPC IPC(8): A61K9/38A61K31/426A61K47/42A61P1/14
Inventor 叶澄
Owner 叶澄
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