Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Mesoporous gating Fe<2+> donor and Fe<2+>-dependence anti-tumor medicine cotransport system, and preparation method and application thereof

An anti-tumor drug and dependence technology, applied in the field of medicine, can solve the problems such as the sensitivity to alternating magnetic fields that have not been seen

Inactive Publication Date: 2015-11-18
ZHENGZHOU UNIV
View PDF4 Cites 8 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, using the hydrazone bond can realize the fixed-point release of the guest molecule at the tumor site, which has broad application prospects. However, there has been no use of the sensitivity of HollowIONPs to the alternating magnetic field so far, and the remote control of the alternating magnetic field can be used to realize the positioning of the tumor. Public Reporting of Mechanistic Therapeutics

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] In the specific implementation of the present invention, the mesoporous gated Fe 2+ Donor and Fe 2+ The co-transport system of dependent antitumor drugs is realized by the following steps:

[0024] (1) Synthesis of hollow mesoporous magnetic nanoparticles (HollowIONPs): Add 0.3-0.6g of sodium dodecylbenzene sulfonate to 30-50ml of ethylene glycol at room temperature, stir to form a clear and transparent solution, and then Add 1-2g of ferric chloride and 2-3.5g of sodium acetate into the clear and transparent solution, stir evenly, put into the autoclave, seal, and react at 160-180℃ for 10-15 hours to precipitate a black product. The black product is absorbed by the magnet and the liquid is discarded. The black product is washed with distilled water and absolute ethanol until it is neutral. The washed product is dried in a vacuum drying oven at 60°C for 15-20 hours to form hollow mesoporous magnetic nanoparticles (HollowIONPs);

[0025] (2) Synthesis reaction of hollow mesop...

Embodiment 2

[0029] In the specific implementation of the present invention, the mesoporous gated Fe 2+ Donor and Fe 2+ The co-transport system of dependent antitumor drugs is realized by the following steps:

[0030] (1) Synthesis of hollow mesoporous magnetic nanoparticles (HollowIONPs): Add 0.16g of sodium dodecylbenzene sulfonate to 15ml of ethylene glycol at room temperature, stir to form a clear and transparent solution, and then add 0.54g of Ferric chloride and 0.93g sodium acetate were added to the clear and transparent solution, stirred evenly, put into the autoclave, sealed, reacted at 150-200℃ for 8-20 hours, the black product precipitated out, the black product was absorbed with a magnet, and discarded The liquid and the black product are washed with distilled water and absolute ethanol to neutrality in turn, and the washed product is dried in a vacuum drying oven at 60°C for 12-24 hours to form hollow mesoporous magnetic nanoparticles (HollowIONPs);

[0031] (2) Synthesis reaction ...

Embodiment 3

[0035] In the specific implementation of the present invention, the mesoporous gated Fe 2+ Donor and Fe 2+ The co-transport system of dependent antitumor drugs is realized by the following steps:

[0036] (1) Synthesis of hollow mesoporous magnetic nanoparticles (HollowIONPs): at room temperature, add 0.48g of sodium dodecylbenzene sulfonate to 45ml of ethylene glycol, stir to form a clear and transparent solution, and then add 1.52g of Ferric chloride and 2.72g sodium acetate were added to the clear and transparent solution, stirred evenly, put into the autoclave, sealed, and reacted at 175℃ for 14 hours. The black product was precipitated. The black product was absorbed with a magnet, and the liquid was discarded. Wash with distilled water and absolute ethanol to neutrality in turn, and place the washed product in a vacuum drying oven at 60°C for 18 hours to form hollow mesoporous magnetic nanoparticles (HollowIONPs);

[0037] (2) Synthesis reaction of hollow mesoporous magnetic ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Particle sizeaaaaaaaaaa
Molecular weightaaaaaaaaaa
Login to View More

Abstract

The invention relates to a mesoporous gating Fe<2+> donor and Fe<2+>-dependence anti-tumor medicine cotransport system and a preparation method and application thereof. The mesoporous gating Fe<2+> donor and Fe<2+>-dependence anti-tumor medicine cotransport system can be effectively prepared and can be applied to preparing anti-tumor treatment medicine. The system is characterized in that hyaluronic acid and hollow mesoporous magnetic nano particles are subjected to chemical attachment by hydrazone bonds, nano layers are formed in water media, and Fe<2+>-dependence anti-tumor medicine is fed into mesopores of the hollow mesoporous magnetic nano particles, so that the mesoporous gating Fe<2+> donor and Fe<2+>-dependence anti-tumor medicine cotransport system can be formed; the particle size of the mesoporous gating Fe<2+> donor and Fe<2+>-dependence anti-tumor medicine cotransport system is 20-500nm; the molecular weight of the hyaluronic acid is 600-400000 Daltons. The mesoporous gating Fe<2+> donor and Fe<2+>-dependence anti-tumor medicine cotransport system, the preparation method and the application have the advantages that the mesoporous gating Fe<2+> donor and Fe<2+>-dependence anti-tumor medicine cotransport system can be used for remote positioning and regulating tumor multi-mechanism treatment, and accordingly the mesoporous gating Fe<2+> donor and Fe<2+>-dependence anti-tumor medicine cotransport system, the preparation method and the application have huge economical and social benefits.

Description

Technical field [0001] The invention relates to medicine, in particular to a mesoporous gated Fe 2+ Donor and Fe 2+ Dependent anti-tumor drug co-transport system and its preparation method and application. Background technique [0002] 1. Fe 2+ Donor and Fe 2+ Co-transport of dependent drugs (artemisinin) can significantly enhance the therapeutic effect [0003] Artemisinin (artemisinin, ART) is a sesquiterpene lactone compound isolated from the traditional Chinese medicine Artemisia annua. A series of derivatives (dihydroartemisinin, artesunate, etc.) are subsequently synthesized and are widely used Treatment of malaria. Experiments have shown that artemisinin drugs (for convenience, represented by artemisinin (ART) in the following text), in addition to the above-mentioned therapeutic effects, also have a strong killing effect on tumor cells. [0004] Fe in tumor cells 2+ It can react with the unique peroxy bridge structure (-O-O-) in artemisinin molecules to produce free radica...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K47/36A61K47/04A61K41/00A61K9/51A61P35/00
Inventor 张振中张慧娟侯琳张红岭陈倩倩焦晓静
Owner ZHENGZHOU UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com