Preparation of polypyrrole/gel alginate with three dimensional structure and electrical stimulation and pH response and double control drug release

A three-dimensional structure, double control technology, applied in the field of material synthesis and biomedicine, can solve the problems of limited application, and achieve the effect of simple and easy preparation method and delayed release

Active Publication Date: 2015-11-25
CHANGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, pure alginate showed little response to electrical stimulation under electric field conditions
This reason limits its application in the field of electrochemistry, especially in the release of drugs by electrical stimulation

Method used

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  • Preparation of polypyrrole/gel alginate with three dimensional structure and electrical stimulation and pH response and double control drug release
  • Preparation of polypyrrole/gel alginate with three dimensional structure and electrical stimulation and pH response and double control drug release
  • Preparation of polypyrrole/gel alginate with three dimensional structure and electrical stimulation and pH response and double control drug release

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The preparation of salicylic acid-doped polypyrrole nanoparticles / alginate hydrogel includes the following steps:

[0023] (1) Prepare 5 mL of an aqueous solution of 10 mmol / L salicylic acid, weigh 70 mg of sodium dodecylbenzene sulfonate, add it to the above solution and stir to dissolve. Pipette 0.4 mL of a mixed solution of pyrrole and cyclohexane (volume ratio 1:3) and add it dropwise to the above solution, place in an ice bath and magnetically stir for 1.5 h. After the reaction, the solution was ultrasonically treated for 5 min to form a microemulsion. Add 10% polyvinyl alcohol solution, stir evenly and place in ice bath. Add 10 mL of 0.15 mol / L ammonium persulfate aqueous solution dropwise to the microemulsion, and ice-bath for 24 h. After centrifugation and washing for 5 times, freeze-drying was carried out for 24 hours to obtain salicylic acid-doped polypyrrole nanoparticles. Its scanning electron microscope picture is as figure 1 As shown, the polypyrrole n...

Embodiment 2

[0026] The in vitro release behavior of drugs under different potential conditions includes the following steps:

[0027] The preparation process of salicylic acid-doped polypyrrole nanoparticles / alginate hydrogel is the same as that of Example 1.

[0028] (1) Prepare 0.1mol / L phosphate buffer solution (PBS, containing 0.15mol / LNaCl, pH7.4) for simulating human environment, take 15mg of composite material, place it in a dialysis bag, and suspend the dialysis bag in 50mL Magnetic stirring was performed at a speed of 100 rpm in PBS, and electrical stimulation release was performed at 37°C. Drug release from the composite was performed using two stainless steel plates as conditions for applying an electric field. Adjust the electric field strength to 0V, 0.2V, 0.4V and 0.6V, release for 11.5h respectively;

[0029] (2) Draw 3mL of solution from the solution every 0.5h, measure the content of salicylic acid, and supplement the same volume of PBS at the same time. The content of...

Embodiment 3

[0031] The in vitro release behavior of drugs under different pH conditions includes the following steps;

[0032] The preparation process of salicylic acid-doped polypyrrole nanoparticles / alginate hydrogel is the same as that of Example 1.

[0033](1) Prepare 0.1mol / L phosphate buffered saline solution (PBS, containing 0.15mol / LNaCl) for simulating the human body environment, take 15mg of the composite material, place it in a dialysis bag, and suspend the dialysis bag in 50mL of PBS to Magnetic stirring was performed at a speed of 100 rpm, and electrical stimulation release was performed at 37°C. Adjust the pH of PBS to 3.4, 5.4, 7.4 and 9.4, release 11.5h respectively;

[0034] (2) Draw 3mL of solution from the solution every 0.5h, measure the content of salicylic acid, and supplement the same volume of PBS at the same time. The content of salicylic acid is measured at 298nm using ultraviolet spectrophotometry, and the cumulative drug release percentage at different times ...

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Abstract

The invention relates to preparation of polypyrrole / gel alginate with a three dimensional structure and electrical stimulation and pH response and application of the polypyrrole / gel alginate in double control drug release. A preparation method comprises the following steps: preparing nanoparticles of salicylic acid doping polypyrrole, preparing salicylic acid doping polypyrrole nanoparticles / hydrogel alginate and applying the same in the double control drug release. The preparation method has the following advantages that the polypyrrole with the three dimensional structure / hydrogel alginate has electrical stimulation sensibility and drug release behavior of pH response, and that drug release can be controlled dually, and that the preparation method of materials is simple and convenient and feasible, and that the drug release is postponed, and that a drug efficacy is maintained for a longer period of time in a body.

Description

technical field [0001] The invention relates to the preparation of a polypyrrole / alginate gel with three-dimensional structure and electric stimulation and pH response and its application to dual control drug release, belonging to the fields of material synthesis and biomedicine. technical background [0002] Smart drug release systems with stimuli-responsive features have attracted great interest in the past decades. To a certain extent, the intelligent drug sustained release system reduces the possible adverse reactions of drugs and improves the stability and effective utilization of drugs. There are many kinds of external stimuli that can trigger it to release drugs, including: electric field, magnetic field, pH value, light, heat, etc. In the study of drug sustained-release materials, pH-sensitive alginate is widely used in drug sustained-release systems that respond to pH. [0003] Alginate is a biocompatible and non-toxic natural polysaccharide extracted from seaweed...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08L79/04C08L5/04C08K5/13A61K47/34A61K47/36A61K9/06A61K31/60A61P29/00A61P7/02
Inventor 孔泳葛寒砺邓林红潘艳
Owner CHANGZHOU UNIV
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