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Preparation process of interventional therapy magnetic targeting drug carrier

A technology of interventional therapy and preparation technology, which is applied in the direction of drug combination, non-active ingredient medical preparations, pharmaceutical formulations, etc. It can solve the problem of unsafe reduction of particle agglomeration, negative effects of polymer viscosity, unfavorable drug combination and adhesion, etc. problem, to achieve good stabilization effect, reduce production cost, and achieve the effect of small content

Inactive Publication Date: 2015-12-09
莒县人民医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After surface modification by SAA, CNTs exhibit good dispersibility and processability, as mentioned above, but when used in the field of gene therapy, it is necessary to combine drugs and polymer materials, and use SAA-modified Fe 3 o 4 Magnetic microspheres, ①It has a negative effect on the viscosity of the polymer, which is not conducive to the binding and attachment of drugs; ②It is necessary to repeatedly verify whether SAA and drug activity conflict, and Fe after the same SAA modification 3 o 4 Magnetic microspheres cannot be used for all drug carriers; ③The in vivo toxicity of surfactants must be fully evaluated and carefully selected; ④The cost of SAA modification is high
In summary, many steps and the inability to safely reduce the "particle agglomeration" in the synthesis process are the biggest disadvantages of the current synthesis method

Method used

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  • Preparation process of interventional therapy magnetic targeting drug carrier

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] (1) Weigh 8 moles of NaOH, dissolve in deoxygenated pure water to form a 1.3mol / L solution, add 110g of water-soluble starch, and stir at 25°C until completely dissolved; form a mixed solution; add the mixed solution to the reaction kettle , seal the reactor, use high-purity nitrogen to purge the reactor through the inlet valve, and discharge the internal air; because the soluble starch is added to the hot NaOH solution to undergo gelatinization reaction, the starch molecules in the granules stretch and diffuse in all directions, and the dissolution Outside the granule, the expanded starch molecules will be connected and entangled with each other to form a network of hydrocolloids. When the starch enters the granule disintegration stage of the gelatinization reaction, the viscosity of the solution is the largest, enabling the starch molecules to wrap around NaOH, inhibiting the reaction speed of NaOH with iron ions and ferrous ions, and inhibiting the formation of Fe fro...

Embodiment 2

[0031] (1) Weigh 2 moles of NaOH, dissolve in deoxygenated pure water to form a 1.0mol / L solution, heat to 60°C, add 40g of soluble starch, stir until completely gelatinized, and form a mixed solution; add the mixed solution to Into the reactor, seal the reactor, use high-purity nitrogen to purge the reactor through the inlet valve, and discharge the internal air;

[0032] (2) Weigh 0.25 moles of FeCl 3 ·6H 2 O, 0.25 mol FeCl 2 4H 2 O is dissolved in deoxygenated pure water to form a mixed solution; its concentration is 1.0mol Fe per liter of solution 3+ and 1.0molFe 2+ .

[0033] (3) Add the mixed solution obtained in step (2) dropwise to the sodium hydroxide starch gelatinization solution obtained in step (1) through a feed valve. The proportion of raw materials added is molar ratio OH — : Fe 3+ : Fe 2+ =8.0:1.0:1.0, heat the reactor to 180°C, keep it warm for 10 hours, after cooling down naturally, wash and dry to obtain carbon-coated nano-magnetic Fe 3 o 4 .

...

Embodiment 3

[0036] (1) First weigh 8 moles of NaOH, dissolve it in deoxygenated pure water to form a 1.2mol / L solution, add 80g of pregelatinized starch at 40°C, and stir until completely dissolved; ultrasonically mix at a frequency of 200Hz, and ultrasonically Make the air bubbles in the mixture vibrate under the action of sound waves, and when they reach a certain limit, they will grow and collapse to play a role of cavitation. Using ultrasonic cavitation, NaOH and starch molecules in the solution are evenly mixed and the size of starch particles is controlled. evenly distributed. Add the mixed solution into the reaction kettle, seal the reaction kettle, use high-purity nitrogen to purge the reaction kettle through the inlet valve, and discharge the internal air;

[0037] (2) Weigh 1.5 moles of FeCl 3 ·6H 2 O, 1 mole FeCl 2 4H 2 O is dissolved in deoxygenated pure water to form a mixed solution; its concentration is 1.5mol Fe per liter of solution 3+ and 1.0molFe 2+ .

[0038] (3...

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Abstract

The invention discloses a preparation process of an interventional therapy magnetic targeting drug carrier, and belongs to an interventional therapy carrier. The preparation process is characterized in that a molar ratio of NaOH, FeCl3.6H2O and FeCl2.4H2O is as follows: OH<->: Fe<3+>: Fe<2+>=8.0: (1.0 to 1.8): 1.0. The preparation process comprises the following steps: first pasting and mixing sodium hydroxide starch, dropwise adding a mixed iron solution into a pasted mixed solution, carrying out the reaction in a high-temperature reaction kettle in an inert atmosphere, preserving the heat for 6 to 10 hours at the temperature of 180 to 240 DEG C, naturally cooling, then washing and drying to obtain carbon-coated ferriferrous oxide. Compared with the prior art, the weaknesses of a magnetic particle carrier for a traditional target therapy that the coating process is complicated, the production cost is high, the performance of a product is unstable and the like can be solved.

Description

technical field [0001] The invention relates to a carrier for interventional therapy, in particular to a preparation method for a magnetic guidance drug carrier for interventional therapy. Background technique [0002] Interventional therapy is the main method of non-surgical treatment of primary liver cancer, mainly including transarterial chemoembolization (TACE). The current TACE operation is mostly to directly inject the mixed emulsion of chemotherapy drugs and lipiodol into the blood supply blood vessels of the tumor through the catheter. kill tumors. With the continuous improvement of "tumor targeted therapy" technology, "drug microsphere embolization" has gradually entered into clinical practice. After the drug microspheres are injected into the tumor supplying artery through the arterial cannula, the embolization of the tumor capillary network is relatively complete, which is different from conventional methods. Compared with embolic agents, it is less likely to fo...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K47/04A61K47/02A61P1/16
Inventor 何孝隆杨会明周洪珍
Owner 莒县人民医院
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