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Method for preparing keratin/ hydroxyethyl methacrylate(HEMA) composite hydrogel of interpenetrating polymer network structure and application of composite hydrogel

An interpenetrating network structure, methacrylic acid technology, used in the field of composite materials and biomedical materials, can solve the problems of decomposition, poor mechanical properties, low loading, etc.

Inactive Publication Date: 2015-12-23
NORTHWEST NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

CN102977534A discloses the preparation of a sodium alginate and polydiacetone acrylamide interpenetrating network gel, which is used as a drug carrier and overcomes the disadvantage that sodium alginate has a low loading capacity of hydrophobic drugs
[0005] Feather keratin, as a natural polymer material with abundant resources and low price, has good biocompatibility, degradability and hydrophobicity, and has physical and chemical properties due to its high content of cystine, but it is easily decomposed by proteases and poor mechanical properties

Method used

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  • Method for preparing keratin/ hydroxyethyl methacrylate(HEMA) composite hydrogel of interpenetrating polymer network structure and application of composite hydrogel
  • Method for preparing keratin/ hydroxyethyl methacrylate(HEMA) composite hydrogel of interpenetrating polymer network structure and application of composite hydrogel
  • Method for preparing keratin/ hydroxyethyl methacrylate(HEMA) composite hydrogel of interpenetrating polymer network structure and application of composite hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Under the protection of inert gas, dissolve 0.1g of feather keratin in 5mL of 0.8mol / L urea solution, stir at 50°C for 20min to completely dissolve the keratin; add 10mg of dithiothreitol and stir for 10min; add 1mL of formazan base acrylic- β -Hydroxyethyl ester, stirred for 1h; added 50mg N,N - Methylenebisacrylamide mixed evenly; add 10mg ammonium persulfate, stir for 20min; then add 0.1mL glutaraldehyde and continue stirring for 5min; then let the reaction solution stand at 40°C for 3h; soak and wash with ethanol and water , and dry to obtain a keratin composite hydrogel with an interpenetrating network structure. The composite hydrogel has a cumulative release rate of 72.6% for doxorubicin hydrochloride at body temperature (37°C).

Embodiment 2

[0050] Under the protection of an inert gas, dissolve 0.3g of feather keratin in 8mL of 1mol / L sodium hydroxide solution, stir at 60°C for 25min to completely dissolve the keratin; add 20mg of dithiothreitol and stir for 20min; add 2mL of formazan base acrylic- β -Hydroxyethyl ester, stirred for 2h; added 100mg N,N -Methylenebisacrylamide is mixed evenly, add 15mg ammonium persulfate, stir for 30min, then add 0.3mL glutaraldehyde, continue stirring for 10min; then let the reaction solution stand at 50°C for 5h; After washing and drying, a keratin composite hydrogel with an interpenetrating network structure is obtained. The composite hydrogel has a cumulative release rate of 84.4% for doxorubicin hydrochloride at body temperature (37°C).

Embodiment 3

[0052] Under the protection of inert gas, disperse 0.5g feather keratin in 10mL5mol / L urea, stir at 65°C for 35min to completely dissolve the keratin; add 40mg of mercaptoethanol and stir for 30min; add 3mL of methacrylic acid- β -Hydroxyethyl ester, stirred for 3h; added 100mg N,N - Methylenebisacrylamide is mixed evenly; add 30mg of ammonium persulfate and stir for 30min; then add 0.5mL of glutaraldehyde and continue stirring for 20min; then let the reaction solution stand at 65°C for 6h; After washing and freeze-drying, a keratin composite hydrogel with an interpenetrating network structure is obtained. The composite hydrogel has a cumulative release rate of 90.9% for doxorubicin hydrochloride at body temperature (37°C).

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Abstract

The invention provides a method for preparing keratin / hydroxyethyl methacrylate(HEMA) composite hydrogel of an interpenetrating polymer network structure. Natural polymer keratin and functional monomer hydroxyethyl methacrylate(HEMA) are used as raw materials, self-crosslinking polymerization is conducted under the action of a cross-linking agent and an initiating agent, and macromolecules in a composite hydrogel polymer are interpenetrated in different inlaid modes in three-dimensional space so that an interlaced network structure can be formed. The composite hydrogel has good swelling and deswelling properties, and further has pH sensibility. Vitro drug release experiments show that the composite hydrogel has a slow-release effect on small molecule compound rhodamine B, anti-cancer drug doxorubicin hydrochloride and macromolecular compound bovine serum albumin model drugs. Hence, the keratin / hydroxyethyl methacrylate(HEMA) composite hydrogel can be used as a drug carrier to be applied to a drug controlled release system.

Description

technical field [0001] The invention relates to the preparation of a keratin polymer composite hydrogel, in particular to a keratin / methacrylic acid- β - preparation of hydroxyethyl ester composite hydrogel; the present invention also relates to the keratin / methacrylic acid- β The application of the -hydroxyethyl ester composite gel as a drug carrier belongs to the field of composite materials and the technical field of biomedical materials. Background technique [0002] With the advancement of science and technology, the research on drug controlled release system has attracted more and more attention. Through the polymer drug controlled release system, the drug can achieve time or space controlled release in the carrier system, maintain the optimal concentration of the drug in the blood for disease treatment, and avoid the high blood drug concentration during routine administration. Poisoning, the problem that the treatment is ineffective when it is low. [0003] Interpe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/24C08J3/075C08F289/00C08F220/28C08F222/38A61K47/42
Inventor 何玉凤钱文珍郭菊花王荣民
Owner NORTHWEST NORMAL UNIVERSITY
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