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Antimicrobial coating composition, medical implant material containing antimicrobial coating and preparation method of medical implant material

A technology for antibacterial coatings and implant materials, applied in coatings, medical science, prostheses, etc., can solve problems such as human toxicity, and achieve the effects of reduced biological toxicity, low manufacturing cost, and strong coating adhesion

Inactive Publication Date: 2016-02-17
BEIJING NATON TECH GRP CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, silver ions are also a double-edged sword. While killing bacteria, they also have certain toxicity to the human body.

Method used

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  • Antimicrobial coating composition, medical implant material containing antimicrobial coating and preparation method of medical implant material
  • Antimicrobial coating composition, medical implant material containing antimicrobial coating and preparation method of medical implant material
  • Antimicrobial coating composition, medical implant material containing antimicrobial coating and preparation method of medical implant material

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Experimental program
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preparation example Construction

[0040] Further, the preparation method comprises the following steps:

[0041] S1: immersing the substrate of the implant material in an aqueous solution of mussel adhesion protein, cleaning and drying to obtain a substrate containing a film layer of mussel adhesion protein;

[0042] S2: immerse the base material obtained in step S1 in a silver ion solution, wash and dry.

[0043]In step S1, the concentration and immersion time of the mussel adhesive protein aqueous solution can be adjusted according to the required protein film layer. In a preferred embodiment of the present invention, the concentration of the mussel adhesive protein aqueous solution can be 0.05-5mg / ml , the soaking time can be 5-120 minutes.

[0044] In step S1, the pH value of the mussel adhesion protein aqueous solution can be acidic or alkaline, and the preferred pH value is 3.0-9.0, which can be adjusted to the required pH value by commonly used dilute acid, dilute alkali solution or buffer solution. p...

Embodiment 1

[0050] Embodiment 1 contains the preparation of the metal titanium sheet of antibacterial coating

[0051] (1) Prepare Mefp-1 aqueous solution, adjust protein concentration to 0.5 mg / ml, and pH value to 4.0. Soak a clean titanium sheet (purity>99%) in the Mefp-1 aqueous solution for 2 hours, take out the titanium sheet, wash and dry it, and obtain a titanium sheet loaded with a Mefp-1 protein film layer.

[0052] (2) After immersing the titanium sheet loaded with the Mefp-1 protein film layer in 0.01M silver nitrate solution for 6h, take it out, clean it ultrasonically and dry it, that is, evenly distributed mussel adhesion protein / nano Silver particle antibacterial coating, the coating thickness is about 30nm.

[0053] The X-ray photoelectron energy spectrogram of the titanium sheet that gained contains antibacterial coating is as figure 1 As shown, it indicates that mussel adhesion protein components and elemental silver exist on the surface of the titanium sheet.

[0054...

Embodiment 2

[0055] Embodiment 2 Preparation of titanium alloy sheet containing antibacterial coating

[0056] (1) Prepare Mefp-2 aqueous solution, adjust protein concentration to 1 mg / ml, and pH value to 6.0. The clean titanium alloy sheet (Ti6Al4V) was immersed in the Mefp-2 aqueous solution for 1 h, the titanium alloy sheet was taken out, washed and dried, and the titanium alloy sheet loaded with the Mefp-2 protein film layer was obtained.

[0057] (2) Immerse the titanium alloy sheet loaded with the Mefp-2 protein film layer in a 0.005M silver nitrate solution for 8 hours, take it out, clean it ultrasonically and dry it, so that evenly distributed mussel adhesion protein is obtained on the surface of the titanium alloy sheet / Nano silver particle antibacterial coating, the coating thickness is about 50nm.

[0058] The obtained titanium alloy sheet containing antibacterial coating has good biocompatibility ( figure 2 c) and antibacterial properties ( image 3 c. Figure 4 ).

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Abstract

The invention provides an antimicrobial coating composition, which consists of mussel adhesive protein and silver nanoparticles. The invention also provides a medical implant material containing an antimicrobial coating and a preparation method of the medical implant material. The antimicrobial coating formed by the composition disclosed by the invention, as an antimicrobial coating which is excellent in performance and is safe and reliable, is quite excellent in biocompatibility and antimicrobial activity, free from toxic and side effects and free from rejection reaction. The antimicrobial coating containing medical implant material provided by the invention is strong in antimicrobial activity, good in biocompatibility and is applicable to various substrate materials, and the medical implant material is simple in manufacturing process and strong in universality; and the medical implant material is capable of achieving mass production and clinical application, and the implant material has important social and economic significances.

Description

technical field [0001] The invention relates to the field of medical implant materials, in particular to an antibacterial coating composition, a medical implant material containing an antibacterial coating and a preparation method thereof. Background technique [0002] With the aging of modern society and the accelerated pace of life, the number of patients with orthopedic injuries has increased dramatically. According to statistics, there are more than 2 million cases of artificial prosthesis replacement in the world every year. It is predicted that by 2030, only artificial total knee joint replacement in the United States will Reaching 3.5 million cases per year. Bacterial infection of orthopedic implants and internal fixation devices can lead to catastrophic complications. It is a very difficult problem in the current orthopedic treatment and rehabilitation. It not only brings great pain to patients, but also wastes a lot of medical and health resources. cause huge econo...

Claims

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Application Information

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IPC IPC(8): A61L27/34A61L27/30A61L27/54A61L31/10A61L31/08A61L31/16
Inventor 林昌健杨云张艳梅丁希彧林理文唐佩福张立海
Owner BEIJING NATON TECH GRP CO LTD
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