Spherical nano-porous hydroxylapatite prepared through shells and preparation method thereof

A hydroxyapatite and nanoporous technology, applied in chemical instruments and methods, phosphorus compounds, inorganic chemistry, etc., can solve the problems of waste and utilization of shell resources, and achieve uniform particle size, cheap and easy-to-obtain raw materials, and mild preparation conditions. Effect

Active Publication Date: 2016-02-24
ZHEJIANG SCI-TECH UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] Aiming at the resource waste and utilization of shells, the object of the present invention is

Method used

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  • Spherical nano-porous hydroxylapatite prepared through shells and preparation method thereof
  • Spherical nano-porous hydroxylapatite prepared through shells and preparation method thereof
  • Spherical nano-porous hydroxylapatite prepared through shells and preparation method thereof

Examples

Experimental program
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Effect test

Example Embodiment

[0030] Example 1

[0031] After the mussel shells are washed and dried, they are ground into powder with a particle size of 100 meshes. 0.5g of shell powder is added to the beaker; 20mL of acetic acid solution with a concentration of 0.1g / mL is added, reacted for 1h, centrifuged, and the supernatant is taken. Dilute with deionized water to 50mL; take 50mL of 0.06mol / LH 3 PO 4 Solution, while stirring, add H at a rate of 10 drops / min 3 PO 4 The solution was added dropwise to the solution; then 0.4mmol of trisodium citrate was added to the mixed solution, stirred and reacted for 30 minutes, and then 6g of urea was added; the obtained mixed solution was placed in a water bath at 90°C, stirred and reacted for 5 minutes, and left to stand to Precipitation occurred; finally, the obtained precipitate was filtered, washed twice with deionized water, twice with ethanol, and dried at 70° C. for 24 hours to obtain spherical hydroxyapatite particles.

[0032] The spherical nanoporous hydroxyap...

Example Embodiment

[0034] Example 2

[0035] After the mussel shells are washed and dried, they are ground into powder with a particle size of 100 meshes. 0.5g of shell powder is added to the beaker; 20mL of acetic acid solution with a concentration of 0.1g / mL is added, reacted for 1h, centrifuged, and the supernatant is taken. Dilute with deionized water to 50mL; take 50mL of 0.12mol / LH 3 PO 4 Solution, while stirring, add H at a rate of 10 drops / min 3 PO 4 The solution was added dropwise to the solution; then 0.4mmol of trisodium citrate was added to the mixed solution, stirred and reacted for 30 minutes, and then 6g of urea was added; the obtained mixed solution was placed in a water bath at 90°C, stirred and reacted for 5 minutes, and left to stand to Precipitation occurred; finally, the obtained precipitate was filtered, washed twice with deionized water, twice with ethanol, and dried at 70° C. for 24 hours to obtain spherical hydroxyapatite particles.

Example Embodiment

[0036] Example 3

[0037] After washing and drying the oyster shell, grind it into a powder with a particle size of 200 mesh. Take 0.5g of shell powder and add it to the beaker; add 20ml of acetic acid solution with a concentration of 0.1g / mL, react for 1h, centrifuge and take the supernatant. Dilute with deionized water to 50mL; take 50mL of 0.06mol / LH 3 PO 4 Solution, while stirring, add H at a rate of 20 drops / min 3 PO 4 The solution was added dropwise to the solution; then 0.6mmol of trisodium citrate was added to the mixed solution, stirred and reacted for 30 minutes, and then 6g of urea was added; the prepared mixed solution was placed in a water bath at 80°C, stirred and reacted for 5 minutes, and allowed to stand until Precipitation occurred; finally, the obtained precipitate was filtered, washed twice with deionized water, twice with ethanol, and dried at 70° C. for 24 hours to obtain spherical hydroxyapatite particles.

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Abstract

The invention discloses spherical nano-porous hydroxylapatite prepared through shells and a preparation method thereof, and belongs to the technical field of material preparation. According to the hydroxylapatite prepared through the method, the hydroxylapatite is in a spherical shape, the diameter is 4-5 micrometers, the dispersity is good, the specific surface area is 270 cm<2>/g, the average pore diameter is 18 nm, carbonate radicals are contained, the components are similar to those of hydroxylapatite in the bones, and the biocompatibility is good. The preparation method comprises the following steps that the shells are washed, dried and ground, acetic acid with the concentration of 0.1 g/mL is added to fully react with the ground shells, an H3PO4 solution is dropwise added into a prepared calcium acetate solution, trisodium citrate is added, urea is added after reacting under stirring are performed, a prepared solution is stirred to be subjected to a reaction for 5 min in a water bath at the temperature of 80 DEG C-90 DEG C, standing is performed until precipitates occur, and the obtained precipitates are filtered, washed, dried and then collected. According to the method, shell powder does not need to be calcined, the reaction time is short, the pH does not need to be adjusted, operation is easy, the repeatability is good, the raw materials are easy to obtain, and not only is waste utilization achieved, but also energy conservation and emission reduction are facilitated.

Description

technical field [0001] The invention belongs to the technical field of preparation methods of hydroxyapatite, and in particular relates to a spherical nanoporous hydroxyapatite prepared from shells and a preparation method thereof. technical background [0002] Hydroxyapatite is an important medical material, which is consistent with the composition and structure of hard tissues of the human body, such as bones and teeth. It has good biocompatibility and chemical stability. It has important applications in bone substitutes, hard tissue repair, and carrier materials. Studies have found that hydroxyapatite can also adsorb heavy metal ions and certain organic substances in water. [0003] With the development of my country's marine aquaculture industry, a large number of discarded shells have been produced in coastal areas, and the accumulation of a large number of shells has not only caused environmental pollution, but also prevented effective use of resources. Using shells ...

Claims

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Application Information

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IPC IPC(8): C01B25/32
CPCC01B25/32C01P2002/72C01P2004/61C01P2006/12C01P2006/16
Inventor 孔祥东韩义忠江国华姚菊明陈岑陈侃
Owner ZHEJIANG SCI-TECH UNIV
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