Preparation method of fluor-hydroxyapatite nanoshuttle

A technology of fluorohydroxyapatite and nano-shuttle, which is applied in the direction of nanotechnology, nanotechnology, chemical instruments and methods, etc., can solve the problems of high synthesis operation conditions, harsh process conditions, and large energy consumption, and achieve stable product quality, Low reaction cost and good reproducibility

Inactive Publication Date: 2016-03-09
NORTHWEST UNIV(CN)
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, at present, the synthesis of highly uniform ion-doped nano-hydroxyapatite is carried out in a medium-high temperature environment, the synthesis operating conditions are relatively demanding, the energy consumption is also large, the cost of large-scale preparation is high, and the process conditions are relatively harsh. To a certain extent, there are production safety risks

Method used

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  • Preparation method of fluor-hydroxyapatite nanoshuttle
  • Preparation method of fluor-hydroxyapatite nanoshuttle
  • Preparation method of fluor-hydroxyapatite nanoshuttle

Examples

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Embodiment 1

[0019] Example 1 Preparation of fluorohydroxyapatite nanoshuttle

[0020] In a 50mL beaker, add 2mL oleic acid, 1ml oleylamine, 10mL ethanol, then add 8mL of 0.25M calcium nitrate solution, 8mL of 0.15M sodium phosphate solution and 1.6mL of 0.25M sodium fluoride solution, stir well, seal Seal the mouth of the beaker with a porous film and let it stand at room temperature for 5 days. After the reaction, the precipitate was collected by centrifugation and washed several times with cyclohexane and ethanol to obtain the final product.

[0021] Detection by transmission electron microscopy shows that the product of the reaction is a nano-shuttle with a uniform scale, with a maximum diameter of about 10 nm and a length of about 100 nm, such as figure 1 Shown; The product identified by X-ray powder diffraction is hydroxyapatite, such as figure 2 Shown; After EDS analysis, it is known that the obtained product contains calcium, phosphorus, and fluorine elements, and is fluorine-...

Embodiment 2

[0022] Example 2 Preparation of fluorohydroxyapatite nanoshuttle

[0023] In a 50mL beaker, add 2mL oleic acid, 1ml oleylamine, 10mL ethanol, then add 0.25M calcium nitrate 8mL, 0.15M sodium phosphate solution 8mL and 0.25M sodium fluoride solution 0.8mL, stir well, seal Seal the mouth of the beaker with a porous film, and let it stand in a refrigerator at 4°C for 7 days. After the reaction, the precipitate was collected by centrifugation and washed several times with cyclohexane and ethanol to obtain the final product. The product is a nano-shuttle with uniform scale, the largest diameter is about 6nm, and the length is about 90nm.

Embodiment 3

[0024] Example 3 Preparation of fluorohydroxyapatite nanoshuttle

[0025] In a 50mL beaker, add 4mL oleic acid, 1ml oleylamine, 10mL ethanol, then add 8mL of 0.25M calcium nitrate solution, 8mL of 0.15M sodium phosphate solution and 0.8mL of 0.25M sodium fluoride solution, stir well, seal Seal the mouth of the beaker with a porous film, and let it stand in a thermostat at 10°C for 7 days. After the reaction, the precipitate was collected by centrifugation and washed several times with cyclohexane and ethanol to obtain the final product. The product is a nano-shuttle with uniform size, the largest diameter is about 8nm, and the length is about 100nm.

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Abstract

The present invention provides a preparation method of fluor-hydroxyapatite nanoshuttle. The preparation method comprises the following steps: adding an aqueous calcium salt solution, an aqueous phosphate solution and a fluoride solution into a mixture of oleic acid, oleylamine and ethanol, and performing mineralization at 0-30 DEG C to obtain the pure fluor-hydroxyapatite nanoshuttle. The nanoshuttle prepared by the preparation method of fluor-hydroxyapatite nanoshuttle is uniform in shape and size, and can be used for preparing a biomedical repair material with controlled degradation property.

Description

technical field [0001] The invention relates to a low-temperature mineralization preparation method of fluorine-doped hydroxyapatite nano-shuttle. Background technique [0002] Nano-hydroxyapatite (Ca 10 (OH) 2 (PO 4 ) 6 ,HAp) is the main component of the inorganic phase in human bones and teeth. It has low immunogenicity, no toxic side effects, good conductivity, and good tissue compatibility, and is an excellent raw material for bone substitute materials, plastic and cosmetic surgery, and dentistry. The hydroxyapatite crystal belongs to the hexagonal crystal system, and its special spatial structure enables the three ions in the lattice to be replaced by other ions, thus deriving a series of hydroxyapatite nanomaterials with rich properties, such as F - , Mg 2+ ,Sr 2+ Such doping of HA can improve its mechanical properties and biological activity. However, at present, the synthesis of highly uniform ion-doped nano-hydroxyapatite is carried out in a medium-high temp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B25/32B82Y30/00B82Y40/00
Inventor 郑晓燕衡春宁马海霞范代娣惠俊峰
Owner NORTHWEST UNIV(CN)
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