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Application of traditional Chinese medicine composition to preparing medicine improving cognition impairment

A technology for improving cognition and dysfunction, applied in the direction of drug combination, effective ingredients of hydroxyl compounds, medical preparations containing active ingredients, etc. To solve the problems of radical drugs and other problems, achieve the effects of stable drug properties, good dissolution, and reduced disability

Inactive Publication Date: 2016-03-16
GUIZHOU BAILING GRP PARMACEUTIAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Cognitive dysfunction seriously affects the quality of life of humans, especially middle-aged and elderly people, and there is no good curative drug at present
Western medicine mainly adopts anticoagulation (such as heparin, etc.), anti-platelet aggregation (except aspirin, such as sodium ozagrel, etc.), improving cerebrovascular function (calcium ion antagonists, such as nimodipine, etc.) for the treatment of cerebral infarction recovery period. Sibeline, etc.) and neurotrophic drugs (such as citicoline, edaravone, etc.), especially the effect of aspirin on anti-platelet aggregation has been confirmed, but its gastrointestinal reactions have caused some cerebral infarction Patient stays away

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Get 50kg of ginkgo leaves, 30kg of breviscapella, 50kg of salvia miltiorrhiza, 1kg of borneol, 40kg of hawthorn, 30kg of Gynostemma pentaphyllum, 20kg of Panax notoginseng, and 40kg of garlic as raw materials. Take notoginseng and grind it into fine powder, pass through a 150-mesh sieve to get 3kg of notoginseng fine powder, and the rest is notoginseng coarse powder. Sanqi fine powder is sterilized intermittently for 1-2 hours, cultured for 24 hours, and then sterilized continuously for 3 times, and the notoginseng fine powder obtained after drying is product A. Take borneol and grind it into fine powder, pass through a 150-mesh sieve; take garlic material, add 6 times the amount of water, boil, collect the distillate, separate and extract garlic oil (about 1kg); 1.5h, filter, combine 2 filtrates, recover ethanol, concentrate to a relative density of 1.20, dry under reduced pressure, grind into fine powder, pass through a 150 mesh sieve (about 1.5kg), and use the dregs ...

Embodiment 2

[0014] Get Ginkgo biloba 48kg, Erigeron breviscapus 28kg, Salvia miltiorrhiza 52kg, Borneol 1.2kg, Hawthorn 38kg, Gynostemma pentaphyllum 32kg, Panax notoginseng 19kg, garlic 42kg as raw material, can be made into finished capsule by embodiment 1 method.

Embodiment 3

[0016] Get Ginkgo biloba 52kg, Erigeron breviscapus 32kg, Salvia miltiorrhiza 48kg, Borneol 0.8kg, Hawthorn 41kg, Gynostemma pentaphyllum 28kg, Panax notoginseng 21kg, garlic 38kg as raw material, can be made into finished capsule by embodiment 1 method.

[0017] The present invention can also be prepared into other dosage forms such as tablets, granules, syrups, etc. according to conventional preparation techniques.

[0018] In order to confirm that the obtained product has an effective therapeutic effect, we have carried out a series of clinical experimental studies. The present invention improves the main therapeutic effect of cognitive dysfunction as follows:

[0019] 1. Patients and Methods

[0020] 360 patients in the recovery period of large artery atherosclerotic cerebral infarction (stroke meridian-blood stasis syndrome) were treated with cognitive function improvement therapy in the recovery period of large artery atherosclerotic cerebral infarction.

[0021] On ...

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PUM

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Abstract

The invention discloses application of a traditional Chinese medicine composition to preparing medicine improving cognition impairment. The composition is soft capsules prepared through a conventional preparation technology with ginkgo leaves, herba erigernotis, salviae miltiorrhizae, borneol, hawthorn fruits, gynostemma pentaphyllum, panax notoginseng and garlic as raw materials. The composition is prepared according to Miao medicine theories. The preparation is good in medicine component dissolution, high in bioavailability, little in dose and stable in drug property. The traditional Chinese medicine composition can be used treating vascular cognition impairment caused by atherosclerosis, and symptoms of vascular cognition impairment include inattention, fatigue, expectoration, tiredness and heavy sensation in bodies, luxated teeth, dark purple mouths and lips, dry eyes, constipation, blurred vision, hard breath, gloomy complexion, reddened tongues, greasy fur tongue and the like. The traditional Chinese medicine preparation has the functions of promoting blood circulation to remove blood stasis, nourishing qi and stopping pain.

Description

technical field [0001] The invention relates to an application of traditional Chinese medicine, in particular to the application of a traditional Chinese medicine composition in the preparation of medicine for improving cognitive dysfunction. Background technique [0002] Vascular cognitive impairment is a syndrome ranging from varying degrees of cognitive impairment to dementia caused by cerebrovascular disease or its risk factors. Including vascular mild cognitive impairment, vascular non-dementia cognitive impairment and vascular dementia. It belongs to the category of madness and amnesia in traditional Chinese medicine. The survey found that the prevalence of vascular cognitive impairment among people over 65 years old is about 5%. Carotid atherosclerotic plaque is one of the main risk factors for vascular cognitive impairment. Carotid artery plaque is an obvious feature of carotid atherosclerosis, reflecting the degree of arteriosclerosis; soft plaque and mixed plaqu...

Claims

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Application Information

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IPC IPC(8): A61K36/8962A61P9/10A61P25/28A61K31/045
Inventor 成龙梁日欣许海玉
Owner GUIZHOU BAILING GRP PARMACEUTIAL CO LTD
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