Extraction method of streptomycin sulfate

The technology of streptomycin sulfate and extraction method, which is applied in the field of preparation of pharmaceutical raw materials, can solve the problems of poor color grade of streptomycin sulfate finished products, low product qualification rate, low production efficiency, etc., and achieves good product color grade and high yield. , the effect of high pass rate

Active Publication Date: 2016-04-27
HEBEI SHENGXUE DACHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] 1. The extraction process undergoes two ion exchanges, the line is long, the production efficiency is low, the cost is high, and the yield is low;
[0005] 2. The finished product of streptomycin sulfate obtained by extraction has a poor color grade and a low qualified rate of the product

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] A. Filtration: 60L of streptomycin fermented broth, titer 28550U / ml, product weight 1.713kg. Adjust the pH to 3.5 with oxalic acid, add 60 g of polyaluminum and polyacrylamide (1:1) and stir for 1 hour, then filter through a ceramic membrane;

[0037] B. Resin adsorption: the filtrate is adjusted to pH 7.0 with sodium hydroxide, and then injected into the resin column of D303 resin with a peristaltic pump, the flow rate is 1.5BV / h, and the adsorption capacity is 220g / L;

[0038] C, desorption: carry out desorption with 6% sulfuric acid aqueous solution, flow rate is 0.4BV / h, and volume is 3.5 times of resin volume;

[0039] D. Desalination and neutralization: Desalting and neutralizing the desorption solution with a mixed bed composed of 1×25 resin and 703 resin (1:1) to obtain a refined solution;

[0040] E, decolorization: add the refined solution to 370g activated carbon and stir to decolorize;

[0041] F. Concentration: Concentrate the decolorization solution with...

Embodiment 2

[0045] A. Filtration: 50L of streptomycin fermented broth, titer 28000U / ml, product weight 1.4kg. Adjust the pH to 4.0 with oxalic acid, add 75 g of polyaluminum and polyacrylamide (1:1.5) and stir for 1 hour, then filter through a ceramic membrane;

[0046] B. Resin adsorption: the filtrate is adjusted to pH 6.5 with sodium hydroxide, and then injected into the resin column of D308 resin with a peristaltic pump, the flow rate is 1.0BV / h, and the adsorption capacity is 212g / L;

[0047] C, desorption: carry out desorption with 7% sulfuric acid aqueous solution, flow velocity is 0.2BV / h, and volume is 3.0 times resin volume;

[0048] D. Desalination and neutralization: Desalting and neutralizing the desorption liquid with a mixed bed composed of 1×25 resin and 703 resin (1:1.5) to obtain a refined liquid;

[0049] E, decolorization: add 567g activated carbon to the refined solution and stir to decolorize;

[0050] F. Concentration: Concentrate the decolorization solution with ...

Embodiment 3

[0054] A. Filtration: 52L of streptomycin fermented broth, titer 28600U / ml, product weight 1.487kg. Adjust the pH to 2.0 with oxalic acid, add 78 g of polyaluminum and polyacrylamide (1:2.5) and stir for 1 hour, then filter through a ceramic membrane;

[0055] B. Resin adsorption: the filtrate is adjusted to pH 6.1 with sodium hydroxide, and then injected into the resin column of D303 resin with a peristaltic pump, the flow rate is 1.6BV / h, and the adsorption capacity is 235g / L;

[0056] C, desorption: carry out desorption with 7.8% sulfuric acid aqueous solution, flow velocity is 0.3BV / h, and volume is 3.2 times resin volume;

[0057] D. Desalination and neutralization: desalting and neutralizing the stripped solution with a mixed bed composed of 1×25 resin and 703 resin (1:2) to obtain a refined solution;

[0058] E, decolorization: add the refined solution to 500g activated carbon and stir to decolorize;

[0059] F. Concentration: Concentrate the decolorization solution w...

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PUM

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Abstract

The invention relates to a preparation method of a medicine raw material, and especially relates to an extraction method of streptomycin sulfate. According to the method, the extraction process is simplified, the production efficiency is improved, the invested cost is reduced, the clarity of a filtrate is good, the activated carbon amount is small, the yield is high, the product color grade is good, and the pass rate is high. The method comprises the following steps: A, acidifying a streptomycin sulfate fermentation liquid to the pH of 2.0-4.0, adding a flocculant, stirring, and filtering the liquid with a ceramic membrane; B, adjusting the pH of the filtrate obtained in the step A with sodium hydroxide to 6.0-8.0, and carrying out dynamic adsorption with resin; C, desorbing the saturated resin in the step B with a sulfuric acid aqueous solution; D, desalting and neutralizing the desorption liquid obtained in the step C with a mixed bed to obtain a refined liquid; E, adding the refined liquid obtained in the step D to activated carbon, and filtering; F, concentrating the decolorized liquid obtained in the step E with a nanofiltration membrane; G, removing bacterial endotoxin and pyrogen with an ultrafiltration membrane; and H, spray-drying the product obtained in the step G to obtain the finished product.

Description

technical field [0001] The invention relates to a method for preparing pharmaceutical raw materials, in particular to an extraction method for streptomycin sulfate. Background technique [0002] As we all know, streptomycin sulfate is an aminoglycoside antibiotic, which has a strong antibacterial effect on Mycobacterium tuberculosis, and its minimum inhibitory concentration (MIC) is generally 0.5 mg / L; it is effective against many Gram-negative bacteria (G- ) such as Escherichia coli, Klebsiella pneumoniae, Enterobacter, Salmonella, Brucella, etc. also have antibacterial effects, but have poor antibacterial activity against Gram-positive bacteria (G+); it has a significant effect on the treatment of various tuberculosis Curative effect, it is a first-choice drug for the treatment of tuberculosis, and it is also used for the treatment of urinary tract infection, intestinal infection, tuberculous meningitis, sepsis, pneumonia, peritonitis, etc. caused by plague and Gram-negati...

Claims

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Application Information

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IPC IPC(8): C07H15/238C07H1/06
CPCC07H1/06C07H15/238
Inventor 张健
Owner HEBEI SHENGXUE DACHENG PHARMA
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