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Colloidal bismuth pectin capsule preparation and preparation method

A technology of colloidal bismuth pectin and capsules, which is applied in the field of medicine and can solve problems such as easy agglomeration, high viscosity, and poor effect

Inactive Publication Date: 2016-06-01
王萍
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] However, due to the high viscosity of colloidal bismuth pectin, it will form agglomerates in water, and it needs vigorous stirring to disperse. In the prior art, it is usually diluted with a large amount of fillers, but the effect is poor, and it is still relatively easy to form in water. group

Method used

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  • Colloidal bismuth pectin capsule preparation and preparation method
  • Colloidal bismuth pectin capsule preparation and preparation method
  • Colloidal bismuth pectin capsule preparation and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1 Preparation of Capsule Shells Containing Hydroxypropyl Starch

[0034] prescription:

[0035] Raw materials

Dosage

Hydroxypropyl starch

80g

carrageenan

7g

Chitosan

5g

sodium citrate

3.5g

triethyl citrate

2.7g

Propylene Glycol

2g

[0036] Preparation:

[0037] (1) Chemical glue: put purified water into the chemical glue tank, heat to 80-100°C, then add hydroxypropyl starch, keep warm and stir for 90-180 minutes; then add the remaining ingredients, stir for 10-15 minutes, add activated carbon and stir for decolorization 15min, filter to temporary storage in the insulation barrel;

[0038] (2) The obtained glue solution is processed into a hydroxypropyl starch hollow capsule shell by a full-automatic hollow capsule manufacturing machine.

Embodiment 2a

[0060] Example 2a Preparation of the contents of colloidal bismuth pectin capsules

[0061] Specification 50mg batch 1000 capsules

[0062] prescription

[0063] components

weight

Colloidal bismuth pectin

50g

microcrystalline cellulose

50g

Povidone K30

2g

purified water

18g

Magnesium stearate

1g

[0064] making process:

[0065] (1) adhesive preparation: the povidone K30 of recipe quantity is dissolved in purified water as adhesive, for subsequent use;

[0066] (2) Mixing: take by weighing colloidal bismuth pectin and microcrystalline cellulose of prescription quantity and cross 60 mesh sieves, mix until uniform;

[0067] (3) Granulation: Add binder to the above-mentioned mixed powder to make soft material, pass through 24 mesh sieve and granulate;

[0068] (4) Drying: place the above-mentioned wet granules at 60° C. and blow dry for 1 hour;

[0069] (5) Grain sizing: use a 24-mesh sieve to si...

Embodiment 2b

[0070] Example 2b Preparation of the contents of colloidal bismuth pectin capsules

[0071] Specification 50mg

[0072] Batch 1000 capsules

[0073] prescription

[0074]

[0075]

[0076] making process:

[0077] (1) adding colloidal bismuth pectin and diatomaceous earth to pulverize in a ball mill to obtain a drug-containing adsorbate, and controlling the average particle diameter of the drug-containing adsorbate to be less than 30 microns;

[0078] (2) The drug-containing adsorbate obtained in the step (1) is uniformly mixed with crospovidone and sodium stearate fumarate to obtain the required capsule contents.

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Abstract

The invention provides a colloidal bismuth pectin capsule preparation and a preparation process therefor. A capsule shell of the capsule is a hollow capsule shell containing hydroxypropyl starch. The capsule has good dispersion uniformity and uniform drug concentration in a gastric acid environment, and the preparation process is simple.

Description

technical field [0001] The invention relates to a capsule preparation of colloidal bismuth pectin and a preparation method thereof, in particular to a capsule of colloidal bismuth pectin prepared by using a hollow capsule shell of hydroxypropyl starch, belonging to the technical field of medicine. Background technique [0002] Traditional gelatin capsules use animal protein colloidal gelatin obtained by hydrolysis of animal skin and bone as the capsule shell material, so there are various safety risks. Due to limited sources, unscrupulous merchants use industrial leather processing scraps, or recycled non-leather to make edible or medicinal gelatin, and the animal-derived hollow capsules supported by this may contain excessive heavy metals, high water content, and high cholesterol levels. And cause safety risks such as zoonotic infectious diseases. [0003] Therefore, it is irreplaceable to choose a capsule preparation that is safe, effective, quality controllable and has g...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K31/732A61P1/04A61P31/04
CPCA61K33/245A61K9/1635A61K9/1652A61K9/4816A61K9/4866
Inventor 王平
Owner 王萍
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