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Compound with bimodule imaging and synergy therapy functions and preparing method thereof

A therapeutic effect, dual-mode imaging technology, applied in the directions of medical preparations with non-active ingredients, medical preparations containing active ingredients, preparations for in vivo experiments, etc., can solve problems such as single imaging and single treatment, and achieve good application Prospect, Enhanced Stability, Prevents the Effect of Photobleaching

Inactive Publication Date: 2016-06-22
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to propose a compound based on hydrotalcite intercalation materials and its application in dual-mode imaging and targeted synergistic therapy, which solves the shortcomings of single imaging and the limitations of single treatment

Method used

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  • Compound with bimodule imaging and synergy therapy functions and preparing method thereof
  • Compound with bimodule imaging and synergy therapy functions and preparing method thereof
  • Compound with bimodule imaging and synergy therapy functions and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A: Dissolve magnesium nitrate, aluminum nitrate, zinc phthalocyanine, indocyanine green, and gadolinium nitrate in a mixed solvent of deionized water and ethanol, ultrasonically and stir to mix evenly to obtain a mixed salt solution, in which deionized water The volume ratio of methanol and methanol is 1:1, the molar ratio of magnesium to aluminum is 2:1, the total concentration of magnesium and aluminum is 0.1mol / L, the concentration of zinc phthalocyanine is 0.74mmol / L, and the concentration of indocyanine green is 0.37mmol / L, and the concentration of gadolinium nitrate is 5.55mmol / L;

[0023] B: Dissolve NaOH and FA in deionized water, the concentration of NaOH is 0.31mol / L, and the concentration of FA is 0.015mol / L, ultrasonically and stirred to mix evenly to obtain a mixed solution;

[0024] C: the mixed salt solution that step A obtains is poured into a three-necked flask, and then the mixed solution prepared by step B is placed in N 2 Slowly add it dropwise into...

Embodiment 2

[0027] A: Dissolve magnesium nitrate, aluminum nitrate, zinc phthalocyanine, indocyanine green, and gadolinium nitrate in a mixed solvent of deionized water and ethanol, ultrasonically and stir to mix evenly to obtain a mixed salt solution, in which deionized water The volume ratio of methanol and methanol is 1:1, the molar ratio of magnesium to aluminum is 2:1, the total concentration of magnesium and aluminum is 0.1mol / L, the concentration of zinc phthalocyanine is 0.37mmol / L, and the concentration of indocyanine green is 0.37mmol / L, and the concentration of Gd is 5.55mmol / L;

[0028] B: Dissolve NaOH and FA in deionized water, the concentration of NaOH is 0.74mmol / L, the concentration of FA is 0.03mol / L, ultrasonic and stirred to mix evenly to obtain a mixed solution;

[0029] C: Pour the mixed salt solution obtained in step A into a three-necked flask, and then put the mixed solution prepared in step B in N 2 Slowly add it dropwise into a three-necked flask under protecti...

Embodiment 3

[0031] A: Dissolve magnesium nitrate, aluminum nitrate, zinc phthalocyanine, indocyanine green, Gd, sodium dodecyl dodecyl sulfonate in a mixed solvent of deionized water and ethanol, ultrasonically stir to make it evenly mixed , to obtain a mixed salt solution, wherein the volume ratio of deionized water and methanol is 1:1, the molar ratio of magnesium to aluminum is 2:1, the total concentration of magnesium and aluminum is 0.12mol / L, and the concentration of zinc phthalocyanine is 0.74 mmol / L, the concentration of indocyanine green is 0.37mmol / L, the concentration of gadolinium nitrate is 5.55mmol / L;

[0032] B: Dissolve NaOH and FA in deionized water, the concentration of NaOH is 0.31mol / L, and the concentration of FA is 0.015mol / L, ultrasonically and stirred to mix evenly to obtain a mixed solution;

[0033] C: Pour the mixed salt solution obtained in step A into a three-necked flask, and then put the mixed solution prepared in step B in N 2 Slowly add it dropwise into a...

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Abstract

The invention discloses a compound with bimodule imaging and synergy therapy functions and a preparing method thereof. Due to the adjustability of hydrotalcite laminate elements, the compound has the characteristics of a nuclear magnetic resonance imaging contrast agent by introducing the paramagnetic matter Gd element. By means of the two-dimensional laminated structure of hydrotalcite, the photodynamic reagent zinc phthalocyanine, the photo-thermal reagent indocyanine green and targeting molecule folic acid are inserted into layers of hydrotalcite through co-intercalation. Accumulation of zinc phthalocyanine and indocyanine green is restrained by means of the carrier confinement of a hydrotalcite laminate, photobleaching is prevented, the stability of a photosensitizer is improved, and photodynamic treatment and photo-thermal treatment effects are improved. By means of folic acid molecules introduced through co-intercalation, the compound can be better absorbed by cells, and then treatment effect is improved. Furthermore, indocyanine green molecules emit red fluorescent light, so that the compound has the bimodule imaging function.

Description

[0001] Field [0002] The invention belongs to the technical field of preparation of anticancer drugs, and in particular relates to a compound with dual-mode imaging and synergistic therapeutic effects and a preparation method thereof. Background technique [0003] Photodynamic therapy and photothermal therapy are new cancer treatment methods developed rapidly in the past ten years. Compared with traditional chemotherapy, radiotherapy and surgery, they have the characteristics of less trauma, better targeting, and universal application. focus of attention. At present, the research on photodynamic therapy materials is mainly based on the third generation of photosensitizers: npe6 cross-linked with various substances and phthalocyanines, etc., which can generate singlet oxygen after a certain wavelength of light (Huang Jinling et al., Chinese Science B, 2000, 30(6), 481-483). However, due to the multiple benzene rings in the zinc phthalocyanine structure, it is easy to form di...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K49/00A61K49/08A61K47/22A61K47/04A61P35/00
CPCA61K41/0076A61K41/0052A61K47/02A61K47/22A61K49/0034A61K49/005A61K49/08
Inventor 卫敏关山月梁瑞政张少敏安鸽
Owner BEIJING UNIV OF CHEM TECH
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