Composition capable of achieving sun protection and preventing infection of mosquito-borne viruses such as Zika virus

A technology of virus infection and composition, applied in the field of formulation of pharmaceutical preparations, can solve problems such as poor prognosis, abnormal development of fetal nervous system, heavy burden on patients' families, etc.

Inactive Publication Date: 2016-06-29
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] Current research shows that the symptoms of most patients infected with Zika virus disease are not serious, and generally have fever, rash, conjunctivitis, muscle or joint pain, etc. There is epidemiological evidence that Zika virus infection may lead to "Guillain-Barré syndrome", and pregnant women may infect fetuses through amniotic fluid and placenta after infection, which may cause fetal nervous system development abnormalities, such as fetal microcephaly
Guillain-Barré syndrome and microcephaly are important reasons for the high international attention to Zika virus infection. These two complications have a poor prognosis and will bring a heavy burden to the patient's family
So far, humans do not have a vaccine for prevention or specific drugs for treatment of Zika virus infection

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Mix 10g menthol, 10g borneol, 10g Phellodendron cortex, 10g eggshell membrane paste, 25g lavender oil, 15g monoglyceride, 5g BAAPE, 5g sodium citrate, 5g di-tert-butyl p-cresol, 5g diazoimidazolidine Base urea and 150g of distilled water are dissolved in 700g of 95% alcohol, and then 50g of essence is added to prepare 1kg of base.

[0032] Add 150 g of zinc glycerol, 50 g of gossypol, and 100 g of ascorbyl stearate to 700 g of the base, and stir while adding, so that they are evenly dispersed in the base, and continue stirring for 30 minutes after the addition is complete to obtain a paste.

[0033] The ointment base is diluted according to the ratio of ointment: base = 10:0, 1:1, 1:9, and prepared into preparations with different drug content concentrations for testing.

Embodiment 2

[0035] Dissolve 50g essence, 10g menthol, 30g eggshell membrane powder, 25g lavender oil, 15g Tween, 25g DEET, 5g sodium citrate, 5g di-tert-butyl p-cresol, 5g allantoin, 100g distilled water in 700g cottonseed oil In, then add 50g glycerin, deploy into 1kg oily base.

[0036] Add gossypol 50g and ascorbyl palmitate 100g in this oily base 750g, stir while adding, make them disperse evenly in the oily base. Then continue to stir, add zinc oxide 100g while stirring, continue to stir for 30min after adding, promptly obtain ointment.

[0037] The ointment is diluted with an oily base according to the ratio of ointment: oily base=10:0, 1:1, 1:9, and prepared into preparations with different drug content concentrations for testing.

Embodiment 3

[0039] 40 healthy volunteers were randomly selected, and with reference to the "People's Republic of China Sunscreen Cosmetics Sunscreen Factor (SPF) Measurement Method", the sunscreen effect of the preparations obtained in Example 1 and Example 2 was measured for SPF.

[0040] The results show that each preparation has a good sunscreen effect, and the SPF values ​​corresponding to the preparations made from the ointment are respectively 46 for the ointment, 25 for the 1:1 preparation, and 13 for the 1:9 preparation; Ointment 60, 1:1 preparation 30, 1:9 preparation 15, respectively.

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PUM

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Abstract

The invention belongs to the technical field of formulas of medicinal preparations, particularly relates to a composition capable of achieving sun protection and preventing infection of mosquito-borne viruses such as the Zika virus, and provides an external cream or ointment capable of achieving good sun protection and skin radiation damage repair effects and preventing invasion of mosquito-borne causative viruses such as the Dengue virus, the yellow fever virus, the West Nile virus, the Japanese B encephalitis virus and the Zika virus. Compared with an existing sun protection cream, natural antioxidants such as gossypol and ascorbyl fatty acid ester serve as main effective ingredients for sun protection and skin radiation damage repair and are assisted by glyzinc and zinc oxide, so that the external cream or ointment is safer and more effective; meanwhile, with the mosquito-repellent effect of mosquito repellent and the antiviral activity of gossypol, the risk that mosquito-borne causative viruses such as the Zika virus invade the human body through the skin in a mosquito biting mode is eliminated, and diseases spread by mosquito-borne viruses can be effectively prevented; the external cream or ointment has broad application prospects in the health field.

Description

technical field [0001] The invention belongs to the technical field of formulations of pharmaceutical preparations, in particular to a composition capable of sun protection and preventing mosquito-borne virus infection such as Zika. Background technique [0002] Skin, one of the most important organs of the human body, can block foreign invasion. The skin is the largest organ of the human body. It is located on the surface of the body and consists of three layers: the epidermis, the dermis, and the subcutaneous tissue. The skin covers the whole body, and it protects various tissues and organs in the body from physical, mechanical, chemical and pathogenic microorganisms. Although our skin has a strong ability to resist the stimulation of external adverse factors and rapid self-repair, if our skin is exposed to radiation beyond the tolerance limit and does not pay attention to strengthening protective measures, a series of skin damage will still occur. question. [0003] Ul...

Claims

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Application Information

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IPC IPC(8): A61K35/57A61P17/16A61P17/02A61P31/14A61K31/11A61K31/375A61K31/22A61K31/166A61K33/30
CPCA61K9/0014A61K9/06A61K31/11A61K31/166A61K31/22A61K31/375A61K33/30A61K35/57A61K47/44A61K2300/00Y02A50/30
Inventor 汤鲁宏马乐文季莹莹张俐冯玉舟庄振超杨菲菲熊兵
Owner JIANGNAN UNIV
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